Therapeutic potential of self‐antigen‐specific CD4+CD25+ regulatory T cells selected in vitro from a polyclonal repertoire
CD4+CD25+ regulatory T cells (Treg) play a major role in the prevention of autoimmune diseases. Converging evidence indicates that Treg specific for self‐antigens expressed by target tissues have a greater therapeutic potential than polyclonal Treg. Therefore, the selective expansion of rare self‐an...
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| Veröffentlicht in: | European journal of immunology 2006-04, Vol.36 (4), p.817-827 |
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| container_title | European journal of immunology |
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| creator | Fisson, Sylvain Djelti, Fathia Trenado, Aurélie Billiard, Fabienne Liblau, Roland Klatzmann, David Cohen, José L. Salomon, Benoît L. |
| description | CD4+CD25+ regulatory T cells (Treg) play a major role in the prevention of autoimmune diseases. Converging evidence indicates that Treg specific for self‐antigens expressed by target tissues have a greater therapeutic potential than polyclonal Treg. Therefore, the selective expansion of rare self‐antigen‐specific Treg naturally present in a polyclonal repertoire of Treg is of major importance. In this work, we investigated the potential of different dendritic cell (DC) subsets to expand antigen‐specific Treg in mice. The in vitro selective expansion of rare islet‐specific Treg from polyclonal Treg could only be achieved efficiently by stimulation with CD8+ splenic DC presenting islet antigens. These islet‐specific Treg exerted potent bystander suppression on diabetogenic T cells and prevented type 1 diabetes. This approach opens new perspectives for cell therapy of autoimmune diseases.
See accompanying commentary: http://dx.doi.org/10.1002/eji.200635967 |
| doi_str_mv | 10.1002/eji.200535445 |
| format | Article |
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See accompanying commentary: http://dx.doi.org/10.1002/eji.200635967</description><subject>Animals</subject><subject>Autoantigens - immunology</subject><subject>Autoimmunity</subject><subject>CD4 Antigens - immunology</subject><subject>CD4 Antigens - metabolism</subject><subject>Cell Culture Techniques - methods</subject><subject>Cell Proliferation</subject><subject>Dendritic cells</subject><subject>Dendritic Cells - immunology</subject><subject>Diabetes Mellitus, Experimental - therapy</subject><subject>Female</subject><subject>Immune regulation</subject><subject>Immune Tolerance - immunology</subject><subject>Islets of Langerhans - immunology</subject><subject>Lymphocyte Activation - immunology</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Mice, Transgenic</subject><subject>Receptors, Interleukin-2 - immunology</subject><subject>Receptors, Interleukin-2 - metabolism</subject><subject>Regulatory T cells</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>T-Lymphocytes, Regulatory - immunology</subject><subject>Tolerance</subject><issn>0014-2980</issn><issn>1521-4141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kL9u2zAQh4miRe38GbMWnLoYco-UKIlj4aRJigBZnFmgqGNCgxZVUkrgJegj9Bn7JKFho9k63eHuuw-HHyEXDJYMgH_DjV1yAJGLohAfyJwJzrKCFewjmQOwIuOyhhk5iXEDALIU8jOZsVJwISWbk9f1EwY14DRaTQc_Yj9a5ag3NKIzf3__UWnwiH3q4oDamoStLovF6pKLBQ34ODk1-rCja6rRubg_Qz1iR21Pn-0YPDXBb6lKcrfTzvfJHnDAMHob8Ix8MspFPD_WU_Lw42q9usnu7q9vV9_vMp1DLTKR15p1Mm8NdBJLjVi2VaeMkF3VIjCuWCuKtGYSWqarsuSF4aatQXa6Y2V-Sr4evEPwvyaMY7O1cf-w6tFPsSmrOueC1wnMDqAOPsaAphmC3aqwaxg0-8CbFHjzL_DEfzmKp3aL3Tt9TDgB1QF4sQ53_7c1Vz9v39VvXpyPtw</recordid><startdate>200604</startdate><enddate>200604</enddate><creator>Fisson, Sylvain</creator><creator>Djelti, Fathia</creator><creator>Trenado, Aurélie</creator><creator>Billiard, Fabienne</creator><creator>Liblau, Roland</creator><creator>Klatzmann, David</creator><creator>Cohen, José L.</creator><creator>Salomon, Benoît L.</creator><general>WILEY‐VCH Verlag</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200604</creationdate><title>Therapeutic potential of self‐antigen‐specific CD4+CD25+ regulatory T cells selected in vitro from a polyclonal repertoire</title><author>Fisson, Sylvain ; Djelti, Fathia ; Trenado, Aurélie ; Billiard, Fabienne ; Liblau, Roland ; Klatzmann, David ; Cohen, José L. ; Salomon, Benoît L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3085-538c1d93bf0d9e6cee6b7daf59d7be012a1b543bf190b1c76624f2fb809dcd163</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Animals</topic><topic>Autoantigens - immunology</topic><topic>Autoimmunity</topic><topic>CD4 Antigens - immunology</topic><topic>CD4 Antigens - metabolism</topic><topic>Cell Culture Techniques - methods</topic><topic>Cell Proliferation</topic><topic>Dendritic cells</topic><topic>Dendritic Cells - immunology</topic><topic>Diabetes Mellitus, Experimental - therapy</topic><topic>Female</topic><topic>Immune regulation</topic><topic>Immune Tolerance - immunology</topic><topic>Islets of Langerhans - immunology</topic><topic>Lymphocyte Activation - immunology</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Mice, Transgenic</topic><topic>Receptors, Interleukin-2 - immunology</topic><topic>Receptors, Interleukin-2 - metabolism</topic><topic>Regulatory T cells</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><topic>T-Lymphocytes, Regulatory - immunology</topic><topic>Tolerance</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fisson, Sylvain</creatorcontrib><creatorcontrib>Djelti, Fathia</creatorcontrib><creatorcontrib>Trenado, Aurélie</creatorcontrib><creatorcontrib>Billiard, Fabienne</creatorcontrib><creatorcontrib>Liblau, Roland</creatorcontrib><creatorcontrib>Klatzmann, David</creatorcontrib><creatorcontrib>Cohen, José L.</creatorcontrib><creatorcontrib>Salomon, Benoît L.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fisson, Sylvain</au><au>Djelti, Fathia</au><au>Trenado, Aurélie</au><au>Billiard, Fabienne</au><au>Liblau, Roland</au><au>Klatzmann, David</au><au>Cohen, José L.</au><au>Salomon, Benoît L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Therapeutic potential of self‐antigen‐specific CD4+CD25+ regulatory T cells selected in vitro from a polyclonal repertoire</atitle><jtitle>European journal of immunology</jtitle><addtitle>Eur J Immunol</addtitle><date>2006-04</date><risdate>2006</risdate><volume>36</volume><issue>4</issue><spage>817</spage><epage>827</epage><pages>817-827</pages><issn>0014-2980</issn><eissn>1521-4141</eissn><abstract>CD4+CD25+ regulatory T cells (Treg) play a major role in the prevention of autoimmune diseases. Converging evidence indicates that Treg specific for self‐antigens expressed by target tissues have a greater therapeutic potential than polyclonal Treg. Therefore, the selective expansion of rare self‐antigen‐specific Treg naturally present in a polyclonal repertoire of Treg is of major importance. In this work, we investigated the potential of different dendritic cell (DC) subsets to expand antigen‐specific Treg in mice. The in vitro selective expansion of rare islet‐specific Treg from polyclonal Treg could only be achieved efficiently by stimulation with CD8+ splenic DC presenting islet antigens. These islet‐specific Treg exerted potent bystander suppression on diabetogenic T cells and prevented type 1 diabetes. This approach opens new perspectives for cell therapy of autoimmune diseases.
See accompanying commentary: http://dx.doi.org/10.1002/eji.200635967</abstract><cop>Weinheim</cop><pub>WILEY‐VCH Verlag</pub><pmid>16525991</pmid><doi>10.1002/eji.200535445</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Autoantigens - immunology Autoimmunity CD4 Antigens - immunology CD4 Antigens - metabolism Cell Culture Techniques - methods Cell Proliferation Dendritic cells Dendritic Cells - immunology Diabetes Mellitus, Experimental - therapy Female Immune regulation Immune Tolerance - immunology Islets of Langerhans - immunology Lymphocyte Activation - immunology Mice Mice, Inbred BALB C Mice, Transgenic Receptors, Interleukin-2 - immunology Receptors, Interleukin-2 - metabolism Regulatory T cells Reverse Transcriptase Polymerase Chain Reaction T-Lymphocytes, Regulatory - immunology Tolerance |
| title | Therapeutic potential of self‐antigen‐specific CD4+CD25+ regulatory T cells selected in vitro from a polyclonal repertoire |
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