Inhibition of Heme Oxygenase-1 Increases Responsiveness of Pancreatic Cancer Cells to Anticancer Treatment

Heme oxygenase-1 (HO-1) is believed to represent a key enzyme for the protection of cells against “stress.” Its overexpression in different types of human cancers supports the notion that HO-1 provides a growth advantage and contributes to cellular resistance against chemotherapy and radiotherapy. G...

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Veröffentlicht in:	Clinical cancer research 2005-05, Vol.11 (10), p.3790-3798
Hauptverfasser:	BERBERAT, Pascal O, DAMBRAUSKAS, Zilvinas, GULBINAS, Antanas, GIESE, Thomas, GIESE, Nathalia, KÜNZLI, Beat, AUTSCHBACH, Frank, MEUER, Stefan, BÜCHLER, Markus W, FRIESS, Helmut
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged anticancer therapy Antineoplastic agents Antineoplastic Agents - pharmacology Biological and medical sciences Blotting, Western Carcinoma, Pancreatic Ductal - pathology Cell Proliferation chemotherapy Drug Resistance, Neoplasm Female Gastroenterology. Liver. Pancreas. Abdomen Heme Oxygenase (Decyclizing) - biosynthesis Heme Oxygenase (Decyclizing) - genetics Heme Oxygenase (Decyclizing) - pharmacology Heme Oxygenase-1 Humans Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Medical sciences Membrane Proteins Microscopy, Confocal Middle Aged pancreatic cancer Pancreatic Neoplasms - pathology Pharmacology. Drug treatments Polymerase Chain Reaction radiation Radiation Tolerance RNA, Messenger - analysis RNA, Messenger - biosynthesis Tumor Cells, Cultured Tumors Up-Regulation
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