Sulforaphane-induced Cell Death in Human Prostate Cancer Cells Is Initiated by Reactive Oxygen Species

We have shown previously that sulforaphane (SFN), a constituent of many edible cruciferous vegetables including broccoli, suppresses growth of prostate cancer cells in culture as well as in vivo by causing apoptosis, but the sequence of events leading to cell death is poorly defined. Using PC-3 and...

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Veröffentlicht in:	The Journal of biological chemistry 2005-05, Vol.280 (20), p.19911-19924
Hauptverfasser:	Singh, Shivendra V., Srivastava, Sanjay K., Choi, Sunga, Lew, Karen L., Antosiewicz, Jedrzej, Xiao, Dong, Zeng, Yan, Watkins, Simon C., Johnson, Candace S., Trump, Donald L., Lee, Yong J., Xiao, Hui, Herman-Antosiewicz, Anna
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcysteine - pharmacology Animals Antioxidants - pharmacology Apoptosis - drug effects BH3 Interacting Domain Death Agonist Protein Carrier Proteins - genetics Carrier Proteins - metabolism Caspase 8 Caspases - metabolism Cell Line, Tumor Cells, Cultured Cytochromes c - metabolism Enzyme Activation - drug effects Humans Isothiocyanates Male Membrane Potentials - drug effects Mice Mice, Knockout Mitochondria - drug effects Mitochondria - metabolism Models, Biological Prostatic Neoplasms - drug therapy Prostatic Neoplasms - metabolism Prostatic Neoplasms - pathology Proto-Oncogene Proteins c-bcl-2 - metabolism Reactive Oxygen Species - metabolism Thiocyanates - pharmacology
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