Functional Interactions Between Nucleotide Binding Domains and Leukotriene C4 Binding Sites of Multidrug Resistance Protein 1 (ABCC1)

Multidrug resistance protein 1 (MRP1) is a member of the “C” branch of the ATP-binding cassette transporter superfamily. The NH 2 -proximal nucleotide-binding domain (NBD1) of MRP1 differs functionally from its COOH-proximal domain (NBD2). NBD1 displays intrinsic high-affinity ATP binding and li...

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Veröffentlicht in:	Molecular pharmacology 2005-06, Vol.67 (6), p.1944-1953
Hauptverfasser:	Payen, Lea, Gao, Mian, Westlake, Christopher, Theis, Ashley, Cole, Susan P C, Deeley, Roger G
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Binding Sites - physiology Carrier Proteins - genetics Carrier Proteins - metabolism Cell Line Humans Insecta Leukotriene C4 - metabolism Molecular Sequence Data Multidrug Resistance-Associated Proteins - metabolism
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