Cyclin D3 Expression in Normal Fetal, Normal Adult and Neoplastic Feline Tissue
Cyclin D3 is a tightly regulated cell cycle protein and member of the cyclin D family—a group of proteins that facilitates the progression of a cell through G 1 and into the S phase of the cell cycle. All cells use at least one of the cyclin D proteins for cell cycle regulation. In this study, felin...
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| Veröffentlicht in: | Journal of comparative pathology 2005-05, Vol.132 (4), p.329-339 |
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| container_title | Journal of comparative pathology |
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| creator | Norris, A.J. Griffey, S.M. Lucroy, M.D. Madewell, B.R. |
| description | Cyclin D3 is a tightly regulated cell cycle protein and member of the cyclin D family—a group of proteins that facilitates the progression of a cell through G
1 and into the S phase of the cell cycle. All cells use at least one of the cyclin D proteins for cell cycle regulation. In this study, feline tissues (normal fetal and adult, and neoplastic) were examined immunohistochemically for expression and topographical distribution of cyclin D3. Its distribution was similar to that in human tissues in health and neoplasia, and suggested a dual role of cyclin D3 in cell proliferation and differentiation. Immature lymphoid tissue and proliferating epithelial cells in health and neoplasia were immunoreactive for cyclin D3, whereas expression of the protein in other immunoreactive tissues reflected differentiated cell types. Immunoreactivity for cyclin D3 was particularly striking in germinal centre cells of normal lymph nodes and B-cell lymphomas, and in normal suprabasal epithelial cells of the skin and mucous membranes of the oropharynx and in squamous cell carcinomas at these sites. |
| doi_str_mv | 10.1016/j.jcpa.2004.12.003 |
| format | Article |
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1 and into the S phase of the cell cycle. All cells use at least one of the cyclin D proteins for cell cycle regulation. In this study, feline tissues (normal fetal and adult, and neoplastic) were examined immunohistochemically for expression and topographical distribution of cyclin D3. Its distribution was similar to that in human tissues in health and neoplasia, and suggested a dual role of cyclin D3 in cell proliferation and differentiation. Immature lymphoid tissue and proliferating epithelial cells in health and neoplasia were immunoreactive for cyclin D3, whereas expression of the protein in other immunoreactive tissues reflected differentiated cell types. Immunoreactivity for cyclin D3 was particularly striking in germinal centre cells of normal lymph nodes and B-cell lymphomas, and in normal suprabasal epithelial cells of the skin and mucous membranes of the oropharynx and in squamous cell carcinomas at these sites.</description><subject>Animals</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>cat</subject><subject>Cat Diseases - metabolism</subject><subject>Cat Diseases - pathology</subject><subject>Cats</subject><subject>cell cycle</subject><subject>cell differentiation</subject><subject>cell proliferation</subject><subject>Cyclin D3</subject><subject>Cyclins - metabolism</subject><subject>Female</subject><subject>Fetus - metabolism</subject><subject>gene expression regulation</subject><subject>Immunohistochemistry - methods</subject><subject>Immunohistochemistry - veterinary</subject><subject>Lymphoid Tissue - cytology</subject><subject>Lymphoid Tissue - metabolism</subject><subject>Neoplasms - metabolism</subject><subject>Neoplasms - pathology</subject><subject>Neoplasms - veterinary</subject><subject>Pregnancy</subject><subject>squamous cell carcinoma</subject><subject>tumour</subject><issn>0021-9975</issn><issn>1532-3129</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMFO3DAQhq2KqmxpX6AHyIlTk47tOLYlLmiBthKCQ-FsOfak8iqbBDtB8Pb1ahdx62k0o-__NfoI-UahokCbH5tq4yZbMYC6oqwC4B_IigrOSk6ZPiIrAEZLraU4Jp9T2gCAUoJ9IsdUKM21pityv351fRiKK15cv0wRUwrjUOTD3Ri3ti9ucLb997ft0i_9XNjBF3c4Tr1Nc3AZyQVYPISUFvxCPna2T_j1ME_I4831w_pXeXv_8_f68rZ0XKq5lKrzTLaCtTX1EtBDrbRnqsMOvKINyKZVSDMmsRGtEtK1tmFKikZrjTU_Ief73imOTwum2WxDctj3dsBxSaaRikOjdyDbgy6OKUXszBTD1sZXQ8HsNJqN2Wk0O42GMpM15tDpoX1pt-jfIwdvGTjbA50djf0bQzKPfxhQDhRqDlJk4mJPYLbwHDCa5AIODn2I6Gbjx_C_D_4BPGKLDw</recordid><startdate>20050501</startdate><enddate>20050501</enddate><creator>Norris, A.J.</creator><creator>Griffey, S.M.</creator><creator>Lucroy, M.D.</creator><creator>Madewell, B.R.</creator><general>Elsevier Ltd</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20050501</creationdate><title>Cyclin D3 Expression in Normal Fetal, Normal Adult and Neoplastic Feline Tissue</title><author>Norris, A.J. ; Griffey, S.M. ; Lucroy, M.D. ; Madewell, B.R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c378t-78fd27b52b41d70ed0489d28fef0d816076b8e178f7e65b857cba628756999e43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Animals</topic><topic>Biomarkers, Tumor - metabolism</topic><topic>cat</topic><topic>Cat Diseases - metabolism</topic><topic>Cat Diseases - pathology</topic><topic>Cats</topic><topic>cell cycle</topic><topic>cell differentiation</topic><topic>cell proliferation</topic><topic>Cyclin D3</topic><topic>Cyclins - metabolism</topic><topic>Female</topic><topic>Fetus - metabolism</topic><topic>gene expression regulation</topic><topic>Immunohistochemistry - methods</topic><topic>Immunohistochemistry - veterinary</topic><topic>Lymphoid Tissue - cytology</topic><topic>Lymphoid Tissue - metabolism</topic><topic>Neoplasms - metabolism</topic><topic>Neoplasms - pathology</topic><topic>Neoplasms - veterinary</topic><topic>Pregnancy</topic><topic>squamous cell carcinoma</topic><topic>tumour</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Norris, A.J.</creatorcontrib><creatorcontrib>Griffey, S.M.</creatorcontrib><creatorcontrib>Lucroy, M.D.</creatorcontrib><creatorcontrib>Madewell, B.R.</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of comparative pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Norris, A.J.</au><au>Griffey, S.M.</au><au>Lucroy, M.D.</au><au>Madewell, B.R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cyclin D3 Expression in Normal Fetal, Normal Adult and Neoplastic Feline Tissue</atitle><jtitle>Journal of comparative pathology</jtitle><addtitle>J Comp Pathol</addtitle><date>2005-05-01</date><risdate>2005</risdate><volume>132</volume><issue>4</issue><spage>329</spage><epage>339</epage><pages>329-339</pages><issn>0021-9975</issn><eissn>1532-3129</eissn><abstract>Cyclin D3 is a tightly regulated cell cycle protein and member of the cyclin D family—a group of proteins that facilitates the progression of a cell through G
1 and into the S phase of the cell cycle. All cells use at least one of the cyclin D proteins for cell cycle regulation. In this study, feline tissues (normal fetal and adult, and neoplastic) were examined immunohistochemically for expression and topographical distribution of cyclin D3. Its distribution was similar to that in human tissues in health and neoplasia, and suggested a dual role of cyclin D3 in cell proliferation and differentiation. Immature lymphoid tissue and proliferating epithelial cells in health and neoplasia were immunoreactive for cyclin D3, whereas expression of the protein in other immunoreactive tissues reflected differentiated cell types. Immunoreactivity for cyclin D3 was particularly striking in germinal centre cells of normal lymph nodes and B-cell lymphomas, and in normal suprabasal epithelial cells of the skin and mucous membranes of the oropharynx and in squamous cell carcinomas at these sites.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>15893991</pmid><doi>10.1016/j.jcpa.2004.12.003</doi><tpages>11</tpages></addata></record> |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Animals Biomarkers, Tumor - metabolism cat Cat Diseases - metabolism Cat Diseases - pathology Cats cell cycle cell differentiation cell proliferation Cyclin D3 Cyclins - metabolism Female Fetus - metabolism gene expression regulation Immunohistochemistry - methods Immunohistochemistry - veterinary Lymphoid Tissue - cytology Lymphoid Tissue - metabolism Neoplasms - metabolism Neoplasms - pathology Neoplasms - veterinary Pregnancy squamous cell carcinoma tumour |
| title | Cyclin D3 Expression in Normal Fetal, Normal Adult and Neoplastic Feline Tissue |
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