Association of High-Level MRP1 Expression With Poor Clinical Outcome in a Large Prospective Study of Primary Neuroblastoma

We have previously shown in a retrospective study that expression of the multidrug transporter gene MRP1 (ABCC1) is associated with outcome in neuroblastoma. We have now undertaken a prospective analysis to examine the independent prognostic significance of MRP1 expression in a large cohort of prima...

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Veröffentlicht in:	Journal of clinical oncology 2006-04, Vol.24 (10), p.1546-1553
Hauptverfasser:	HABER, Michelle, SMITH, Janice, BORDOW, Sharon B, FLEMMING, Claudia, COHN, Susan L, LONDON, Wendy B, MARSHALL, Glenn M, NORRIS, Murray D
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Biological and medical sciences Blotting, Western Child Child, Preschool Drug Resistance, Neoplasm Gene Amplification Genes, MDR Humans Infant Infant, Newborn Medical sciences Multidrug Resistance-Associated Proteins - analysis Multidrug Resistance-Associated Proteins - genetics Multivariate Analysis N-Myc Proto-Oncogene Protein Neuroblastoma - drug therapy Neuroblastoma - genetics Neuroblastoma - mortality Neurology Nuclear Proteins - genetics Oncogene Proteins - genetics Oncogenes Prospective Studies Tumors Tumors of the nervous system. Phacomatoses
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