Relationship of P450 2C9 genetic polymorphisms in Chinese and the pharmacokinetics of tolbutamide

Summary Aim: To study the relationship between P450 2C9 genetic polymorphisms and the pharmacokinetics of tolbutamide in Chinese subjects. Methods: P450 2C9 genotype was determined by oligonucleotide microarray. Using tolbutamide as a probe of P450 2C9 activity, P450 2C9 phenotype in 20 healthy in...

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Veröffentlicht in:	Journal of clinical pharmacy and therapeutics 2005-06, Vol.30 (3), p.241-249
Hauptverfasser:	Chen, K., Wang, R., Wen, S.-Y., Li, J., Wang, S.-Q.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Area Under Curve Aryl Hydrocarbon Hydroxylases - genetics Asian Continental Ancestry Group Biological and medical sciences Chromatography, High Pressure Liquid Cytochrome P-450 CYP2C9 DNA microarray Female genetic polymorphisms Genotype Half-Life Humans Hypoglycemic Agents - pharmacokinetics Male Medical sciences Metabolic Clearance Rate Oligonucleotide Array Sequence Analysis P450 2C9 pharmacogenomics Pharmacology. Drug treatments Polymorphism, Genetic tolbutamide Tolbutamide - pharmacokinetics
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