SOCS3 negatively regulates LIF signaling in neural precursor cells

Cytokines that signal through the LIFRβ/gp130 receptor complex, including LIF and CNTF, promote the self-renewal of embryonic and adult neural precursor cells (NPCs). In non-CNS tissues, the protein suppressor of cytokine signaling-3 (SOCS3) negatively regulates signaling through gp130. Here, we ana...

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Veröffentlicht in:	Molecular and cellular neuroscience 2006-04, Vol.31 (4), p.739-747
Hauptverfasser:	Emery, B., Merson, T.D., Snell, C., Young, K.M., Ernst, M., Kilpatrick, T.J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Differentiation Cell Proliferation Cell Shape Cells, Cultured Cytokine Receptor gp130 - metabolism Embryo, Mammalian - cytology Leukemia Inhibitory Factor - genetics Leukemia Inhibitory Factor - metabolism Mice Mice, Knockout Neurons - cytology Neurons - physiology Phenotype Signal Transduction - physiology STAT3 Transcription Factor - metabolism Stem Cells - cytology Stem Cells - physiology Suppressor of Cytokine Signaling 3 Protein Suppressor of Cytokine Signaling Proteins - genetics Suppressor of Cytokine Signaling Proteins - metabolism
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