18Flurodeoxyglucose positron emission tomography in the localization of ectopic ACTH-secreting neuroendocrine tumours
Summary Objective Neuroendocrine tumours (NET) are a rare cause of Cushing's syndrome. These tumours can be very small and therefore difficult to identify. Current localization techniques include CT, MRI and radioisotope scanning, but in a proportion of cases the NET remains occult. Positron e...
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| Veröffentlicht in: | Clinical endocrinology (Oxford) 2006-04, Vol.64 (4), p.371-374 |
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| creator | Kumar, J. Spring, M Carroll, P. V. Barrington, S. F. Powrie, J. K. |
| description | Summary
Objective Neuroendocrine tumours (NET) are a rare cause of Cushing's syndrome. These tumours can be very small and therefore difficult to identify. Current localization techniques include CT, MRI and radioisotope scanning, but in a proportion of cases the NET remains occult. Positron emission tomography (PET) scanning, is a relatively new imaging modality that is increasingly used to detect and monitor lesions with high metabolic activity. We report on the use of PET scanning in the evaluation of the ectopic ACTH syndrome.
Patients Three patients with ectopic ACTH‐dependent Cushing's syndrome with varying difficulty in NET localization are included in the report.
Measurement Positron emission tomography scanning using 18flurodeoxyglucose (FDG) identifies tissue with high metabolic activity. 18FDG‐PET scanning was used in each of these patients and the imaging is presented along with biochemical data.
Results In each case the NET was easily identified using 18FDG‐PET, aiding clinical decision making and therapeutic outcome. A cure was identified by clinical resolution of symptoms and undetectable ACTH levels postsurgery.
Conclusions 18FDG‐PET assisted in localizing small metabolically active NETs, suggesting this imaging modality may have a useful role in identifying NET causing Cushing's syndrome as a result of ectopic ACTH production. |
| doi_str_mv | 10.1111/j.1365-2265.2006.02471.x |
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| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_67828261</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>67828261</sourcerecordid><originalsourceid>FETCH-LOGICAL-i1761-8f819107bf61899c38433664206b794ca0dfb669f7189adec06c43397bbac10c3</originalsourceid><addsrcrecordid>eNpFkU1v1DAQhi0EokvhL6Bc4JYwzoftHDhUUbcF9eOyhaPlOJOtlyQOdiJ2-fU47Lb1xWO9z4zm9UtIRCGh4XzZJTRjRZymrEhSAJZAmnOa7F-R1bPwmqwgA4iBsfyMvPN-BwCFAP6WnFFWiLwAviIzFetudrZBuz9su1lbj9FovZmcHSLsjfcmFJPt7dap8fEQmfB6xKizWnXmr5oW2bYR6smORkcX1eY69qgdTmbYRgOG4Tg0VjszYDTNvZ2df0_etKrz-OF0n5OH9eWmuo5v7q--VRc3saGc0Vi0gpYUeN0yKspSZyLPsmAnBVbzMtcKmrZmrGx5kFWDGpgORMnrWmkKOjsnn49zR2d_z-gnGQxp7Do1oJ29ZFykImU0gB9P4Fz32MjRmV65g3z6qAB8OgHKB-OtU4M2_oXjRdiDQuC-Hrk_psPDiw5yCU7u5JKPXPKRS3Dyf3ByL6vLu6UK_fGx3_gJ98_9yv0Ky2a8kD_vruT3av1jc8vXssz-ASK4nHY</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>67828261</pqid></control><display><type>article</type><title>18Flurodeoxyglucose positron emission tomography in the localization of ectopic ACTH-secreting neuroendocrine tumours</title><source>MEDLINE</source><source>Wiley Online Library All Journals</source><creator>Kumar, J. ; Spring, M ; Carroll, P. V. ; Barrington, S. F. ; Powrie, J. K.</creator><creatorcontrib>Kumar, J. ; Spring, M ; Carroll, P. V. ; Barrington, S. F. ; Powrie, J. K.</creatorcontrib><description>Summary
Objective Neuroendocrine tumours (NET) are a rare cause of Cushing's syndrome. These tumours can be very small and therefore difficult to identify. Current localization techniques include CT, MRI and radioisotope scanning, but in a proportion of cases the NET remains occult. Positron emission tomography (PET) scanning, is a relatively new imaging modality that is increasingly used to detect and monitor lesions with high metabolic activity. We report on the use of PET scanning in the evaluation of the ectopic ACTH syndrome.
Patients Three patients with ectopic ACTH‐dependent Cushing's syndrome with varying difficulty in NET localization are included in the report.
Measurement Positron emission tomography scanning using 18flurodeoxyglucose (FDG) identifies tissue with high metabolic activity. 18FDG‐PET scanning was used in each of these patients and the imaging is presented along with biochemical data.
Results In each case the NET was easily identified using 18FDG‐PET, aiding clinical decision making and therapeutic outcome. A cure was identified by clinical resolution of symptoms and undetectable ACTH levels postsurgery.
Conclusions 18FDG‐PET assisted in localizing small metabolically active NETs, suggesting this imaging modality may have a useful role in identifying NET causing Cushing's syndrome as a result of ectopic ACTH production.</description><identifier>ISSN: 0300-0664</identifier><identifier>EISSN: 1365-2265</identifier><identifier>DOI: 10.1111/j.1365-2265.2006.02471.x</identifier><identifier>PMID: 16584507</identifier><identifier>CODEN: CLECAP</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>ACTH Syndrome, Ectopic - complications ; ACTH Syndrome, Ectopic - diagnostic imaging ; ACTH Syndrome, Ectopic - surgery ; Adult ; Aged ; Biological and medical sciences ; Cushing Syndrome - diagnostic imaging ; Cushing Syndrome - etiology ; Cushing Syndrome - surgery ; Endocrinopathies ; Female ; Fluorodeoxyglucose F18 ; Fundamental and applied biological sciences. Psychology ; Humans ; Male ; Medical sciences ; Neuroendocrine Tumors - complications ; Neuroendocrine Tumors - diagnostic imaging ; Neuroendocrine Tumors - surgery ; Positron-Emission Tomography ; Radiopharmaceuticals ; Vertebrates: endocrinology</subject><ispartof>Clinical endocrinology (Oxford), 2006-04, Vol.64 (4), p.371-374</ispartof><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-2265.2006.02471.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-2265.2006.02471.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,778,782,1414,27911,27912,45561,45562</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17566910$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16584507$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kumar, J.</creatorcontrib><creatorcontrib>Spring, M</creatorcontrib><creatorcontrib>Carroll, P. V.</creatorcontrib><creatorcontrib>Barrington, S. F.</creatorcontrib><creatorcontrib>Powrie, J. K.</creatorcontrib><title>18Flurodeoxyglucose positron emission tomography in the localization of ectopic ACTH-secreting neuroendocrine tumours</title><title>Clinical endocrinology (Oxford)</title><addtitle>Clin Endocrinol (Oxf)</addtitle><description>Summary
Objective Neuroendocrine tumours (NET) are a rare cause of Cushing's syndrome. These tumours can be very small and therefore difficult to identify. Current localization techniques include CT, MRI and radioisotope scanning, but in a proportion of cases the NET remains occult. Positron emission tomography (PET) scanning, is a relatively new imaging modality that is increasingly used to detect and monitor lesions with high metabolic activity. We report on the use of PET scanning in the evaluation of the ectopic ACTH syndrome.
Patients Three patients with ectopic ACTH‐dependent Cushing's syndrome with varying difficulty in NET localization are included in the report.
Measurement Positron emission tomography scanning using 18flurodeoxyglucose (FDG) identifies tissue with high metabolic activity. 18FDG‐PET scanning was used in each of these patients and the imaging is presented along with biochemical data.
Results In each case the NET was easily identified using 18FDG‐PET, aiding clinical decision making and therapeutic outcome. A cure was identified by clinical resolution of symptoms and undetectable ACTH levels postsurgery.
Conclusions 18FDG‐PET assisted in localizing small metabolically active NETs, suggesting this imaging modality may have a useful role in identifying NET causing Cushing's syndrome as a result of ectopic ACTH production.</description><subject>ACTH Syndrome, Ectopic - complications</subject><subject>ACTH Syndrome, Ectopic - diagnostic imaging</subject><subject>ACTH Syndrome, Ectopic - surgery</subject><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Cushing Syndrome - diagnostic imaging</subject><subject>Cushing Syndrome - etiology</subject><subject>Cushing Syndrome - surgery</subject><subject>Endocrinopathies</subject><subject>Female</subject><subject>Fluorodeoxyglucose F18</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Neuroendocrine Tumors - complications</subject><subject>Neuroendocrine Tumors - diagnostic imaging</subject><subject>Neuroendocrine Tumors - surgery</subject><subject>Positron-Emission Tomography</subject><subject>Radiopharmaceuticals</subject><subject>Vertebrates: endocrinology</subject><issn>0300-0664</issn><issn>1365-2265</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkU1v1DAQhi0EokvhL6Bc4JYwzoftHDhUUbcF9eOyhaPlOJOtlyQOdiJ2-fU47Lb1xWO9z4zm9UtIRCGh4XzZJTRjRZymrEhSAJZAmnOa7F-R1bPwmqwgA4iBsfyMvPN-BwCFAP6WnFFWiLwAviIzFetudrZBuz9su1lbj9FovZmcHSLsjfcmFJPt7dap8fEQmfB6xKizWnXmr5oW2bYR6smORkcX1eY69qgdTmbYRgOG4Tg0VjszYDTNvZ2df0_etKrz-OF0n5OH9eWmuo5v7q--VRc3saGc0Vi0gpYUeN0yKspSZyLPsmAnBVbzMtcKmrZmrGx5kFWDGpgORMnrWmkKOjsnn49zR2d_z-gnGQxp7Do1oJ29ZFykImU0gB9P4Fz32MjRmV65g3z6qAB8OgHKB-OtU4M2_oXjRdiDQuC-Hrk_psPDiw5yCU7u5JKPXPKRS3Dyf3ByL6vLu6UK_fGx3_gJ98_9yv0Ky2a8kD_vruT3av1jc8vXssz-ASK4nHY</recordid><startdate>200604</startdate><enddate>200604</enddate><creator>Kumar, J.</creator><creator>Spring, M</creator><creator>Carroll, P. V.</creator><creator>Barrington, S. F.</creator><creator>Powrie, J. K.</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>200604</creationdate><title>18Flurodeoxyglucose positron emission tomography in the localization of ectopic ACTH-secreting neuroendocrine tumours</title><author>Kumar, J. ; Spring, M ; Carroll, P. V. ; Barrington, S. F. ; Powrie, J. K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i1761-8f819107bf61899c38433664206b794ca0dfb669f7189adec06c43397bbac10c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>ACTH Syndrome, Ectopic - complications</topic><topic>ACTH Syndrome, Ectopic - diagnostic imaging</topic><topic>ACTH Syndrome, Ectopic - surgery</topic><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Cushing Syndrome - diagnostic imaging</topic><topic>Cushing Syndrome - etiology</topic><topic>Cushing Syndrome - surgery</topic><topic>Endocrinopathies</topic><topic>Female</topic><topic>Fluorodeoxyglucose F18</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Neuroendocrine Tumors - complications</topic><topic>Neuroendocrine Tumors - diagnostic imaging</topic><topic>Neuroendocrine Tumors - surgery</topic><topic>Positron-Emission Tomography</topic><topic>Radiopharmaceuticals</topic><topic>Vertebrates: endocrinology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kumar, J.</creatorcontrib><creatorcontrib>Spring, M</creatorcontrib><creatorcontrib>Carroll, P. V.</creatorcontrib><creatorcontrib>Barrington, S. F.</creatorcontrib><creatorcontrib>Powrie, J. K.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical endocrinology (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kumar, J.</au><au>Spring, M</au><au>Carroll, P. V.</au><au>Barrington, S. F.</au><au>Powrie, J. K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>18Flurodeoxyglucose positron emission tomography in the localization of ectopic ACTH-secreting neuroendocrine tumours</atitle><jtitle>Clinical endocrinology (Oxford)</jtitle><addtitle>Clin Endocrinol (Oxf)</addtitle><date>2006-04</date><risdate>2006</risdate><volume>64</volume><issue>4</issue><spage>371</spage><epage>374</epage><pages>371-374</pages><issn>0300-0664</issn><eissn>1365-2265</eissn><coden>CLECAP</coden><abstract>Summary
Objective Neuroendocrine tumours (NET) are a rare cause of Cushing's syndrome. These tumours can be very small and therefore difficult to identify. Current localization techniques include CT, MRI and radioisotope scanning, but in a proportion of cases the NET remains occult. Positron emission tomography (PET) scanning, is a relatively new imaging modality that is increasingly used to detect and monitor lesions with high metabolic activity. We report on the use of PET scanning in the evaluation of the ectopic ACTH syndrome.
Patients Three patients with ectopic ACTH‐dependent Cushing's syndrome with varying difficulty in NET localization are included in the report.
Measurement Positron emission tomography scanning using 18flurodeoxyglucose (FDG) identifies tissue with high metabolic activity. 18FDG‐PET scanning was used in each of these patients and the imaging is presented along with biochemical data.
Results In each case the NET was easily identified using 18FDG‐PET, aiding clinical decision making and therapeutic outcome. A cure was identified by clinical resolution of symptoms and undetectable ACTH levels postsurgery.
Conclusions 18FDG‐PET assisted in localizing small metabolically active NETs, suggesting this imaging modality may have a useful role in identifying NET causing Cushing's syndrome as a result of ectopic ACTH production.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>16584507</pmid><doi>10.1111/j.1365-2265.2006.02471.x</doi><tpages>4</tpages></addata></record> |
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| subjects | ACTH Syndrome, Ectopic - complications ACTH Syndrome, Ectopic - diagnostic imaging ACTH Syndrome, Ectopic - surgery Adult Aged Biological and medical sciences Cushing Syndrome - diagnostic imaging Cushing Syndrome - etiology Cushing Syndrome - surgery Endocrinopathies Female Fluorodeoxyglucose F18 Fundamental and applied biological sciences. Psychology Humans Male Medical sciences Neuroendocrine Tumors - complications Neuroendocrine Tumors - diagnostic imaging Neuroendocrine Tumors - surgery Positron-Emission Tomography Radiopharmaceuticals Vertebrates: endocrinology |
| title | 18Flurodeoxyglucose positron emission tomography in the localization of ectopic ACTH-secreting neuroendocrine tumours |
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