The role of polyamines in glucagon-like peptide-2 prevention of TPN-induced gut hypoplasia
Total parenteral nutrition (TPN) of rats has been demonstrated to produce hypoplasia of gut mucosa, and to be associated with reduced immune response and elevated translocation of bacteria from gut to mesenteric lymph nodes, spleen and liver. Treatment of rats being maintained on TPN with the proglu...
Gespeichert in:
| Veröffentlicht in: | Peptides (New York, N.Y. : 1980) N.Y. : 1980), 2006-04, Vol.27 (4), p.883-892 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 892 |
|---|---|
| container_issue | 4 |
| container_start_page | 883 |
| container_title | Peptides (New York, N.Y. : 1980) |
| container_volume | 27 |
| creator | Chance, William T. Sheriff, Sulaiman Dayal, Ramesh Friend, Lou Ann Thomas, Ingrid Balasubramaniam, Ambikaipakan |
| description | Total parenteral nutrition (TPN) of rats has been demonstrated to produce hypoplasia of gut mucosa, and to be associated with reduced immune response and elevated translocation of bacteria from gut to mesenteric lymph nodes, spleen and liver. Treatment of rats being maintained on TPN with the proglucagon fragment, glucagon-like peptide-2 (GLP-2), has been shown to totally prevent small intestine mucosal hypoplasia. In the present study, we found that depletion of polyamines with α-difluromethylornithine (DFMO) significantly reduced the efficacy of GLP-2 in preserving gut mucosa in rats maintained on TPN for 8 days. Co-infusion of GLP-2 with TPN prevented loss of protein and mucosa in duodenum, jejunum and ileum, but not in colon. Addition of DFMO to the infusate prevented the protective effects of GLP-2 in the duodenum and jejunum. In the jejunum, putrescine and spermidine were reduced in DFMO-treated rats, while the ileum exhibited reductions of these polyamines in rats infused with TPN or TPN plus GLP-2. DFMO infusion further reduced these polyamines in the ileum, while levels of spermine were increased. Concentrations of ornithine decarboxylase were elevated in jejunum of rats infused with TPN or TPN plus GLP-2, but were reduced significantly in DFMO-treated rats. These results suggest that normal levels of polyamines are necessary for the expression of GLP-2-induced hyperplasia. Differential effects of GLP-2 and DFMO across gut segments may relate to regional differences in proliferative and anti-apoptotic effects of the treatments. |
| doi_str_mv | 10.1016/j.peptides.2005.09.012 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_67827953</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0196978105004663</els_id><sourcerecordid>67827953</sourcerecordid><originalsourceid>FETCH-LOGICAL-c427t-1bf94077b1ea08bf459611d30d5b1495bc2c5b11e46fe1726080b91154406a63</originalsourceid><addsrcrecordid>eNqFkE1v1DAQhi0EokvhL1S5wC1hxuvY8Q1UlQ-pAg574mI5zmTrJWsHO6m0_56sNqjHnmYOz_vO6GHsBqFCQPnxUI00Tr6jXHGAugJdAfIXbION2pY1Sv2SbQC1LLVq8Iq9yfkAAELo5jW7QsmVaGqxYb93D1SkOFAR-2KMw8kefaBc-FDsh9nZfQzl4P9QsZ4reTEmeqQw-RjOmd2vH6UP3eyoK_bzVDycxjgONnv7lr3q7ZDp3Tqv2e7L3e72W3n_8-v328_3pRNcTSW2vRagVItkoWl7UWuJ2G2hq1sUum4dd8uGJGRPqLiEBlqNWAsB0srtNftwqR1T_DtTnszRZ0fDYAPFORupGq50vX0W5NBIVFItoLyALsWcE_VmTP5o08kgmLN9czD_7ZuzfQPaLPaX4M16YW6P1D3FVt0L8H4FbHZ26JMNzucnTkkJWp6LPl04Wrw9ekomO09hcewTucl00T_3yz8GIKWo</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>20861767</pqid></control><display><type>article</type><title>The role of polyamines in glucagon-like peptide-2 prevention of TPN-induced gut hypoplasia</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Chance, William T. ; Sheriff, Sulaiman ; Dayal, Ramesh ; Friend, Lou Ann ; Thomas, Ingrid ; Balasubramaniam, Ambikaipakan</creator><creatorcontrib>Chance, William T. ; Sheriff, Sulaiman ; Dayal, Ramesh ; Friend, Lou Ann ; Thomas, Ingrid ; Balasubramaniam, Ambikaipakan</creatorcontrib><description>Total parenteral nutrition (TPN) of rats has been demonstrated to produce hypoplasia of gut mucosa, and to be associated with reduced immune response and elevated translocation of bacteria from gut to mesenteric lymph nodes, spleen and liver. Treatment of rats being maintained on TPN with the proglucagon fragment, glucagon-like peptide-2 (GLP-2), has been shown to totally prevent small intestine mucosal hypoplasia. In the present study, we found that depletion of polyamines with α-difluromethylornithine (DFMO) significantly reduced the efficacy of GLP-2 in preserving gut mucosa in rats maintained on TPN for 8 days. Co-infusion of GLP-2 with TPN prevented loss of protein and mucosa in duodenum, jejunum and ileum, but not in colon. Addition of DFMO to the infusate prevented the protective effects of GLP-2 in the duodenum and jejunum. In the jejunum, putrescine and spermidine were reduced in DFMO-treated rats, while the ileum exhibited reductions of these polyamines in rats infused with TPN or TPN plus GLP-2. DFMO infusion further reduced these polyamines in the ileum, while levels of spermine were increased. Concentrations of ornithine decarboxylase were elevated in jejunum of rats infused with TPN or TPN plus GLP-2, but were reduced significantly in DFMO-treated rats. These results suggest that normal levels of polyamines are necessary for the expression of GLP-2-induced hyperplasia. Differential effects of GLP-2 and DFMO across gut segments may relate to regional differences in proliferative and anti-apoptotic effects of the treatments.</description><identifier>ISSN: 0196-9781</identifier><identifier>EISSN: 1873-5169</identifier><identifier>DOI: 10.1016/j.peptides.2005.09.012</identifier><identifier>PMID: 16274854</identifier><identifier>CODEN: PPTDD5</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Animal Feed ; Animals ; Biological and medical sciences ; DFMO ; Fundamental and applied biological sciences. Psychology ; Glucagon-Like Peptide 2 ; Glucagon-Like Peptides - administration & dosage ; Glucagon-Like Peptides - pharmacology ; Hypoplasia ; Intestine, Large - abnormalities ; Intestine, Large - anatomy & histology ; Intestine, Large - drug effects ; Intestine, Small - abnormalities ; Intestine, Small - anatomy & histology ; Intestine, Small - drug effects ; Male ; Organ Size ; Ornithine decarboxylase ; Parenteral Nutrition, Total - adverse effects ; Polyamines - administration & dosage ; Polyamines - pharmacology ; Rats ; Rats, Inbred F344 ; Small intestine ; Vertebrates: endocrinology</subject><ispartof>Peptides (New York, N.Y. : 1980), 2006-04, Vol.27 (4), p.883-892</ispartof><rights>2005</rights><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c427t-1bf94077b1ea08bf459611d30d5b1495bc2c5b11e46fe1726080b91154406a63</citedby><cites>FETCH-LOGICAL-c427t-1bf94077b1ea08bf459611d30d5b1495bc2c5b11e46fe1726080b91154406a63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0196978105004663$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17660962$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16274854$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chance, William T.</creatorcontrib><creatorcontrib>Sheriff, Sulaiman</creatorcontrib><creatorcontrib>Dayal, Ramesh</creatorcontrib><creatorcontrib>Friend, Lou Ann</creatorcontrib><creatorcontrib>Thomas, Ingrid</creatorcontrib><creatorcontrib>Balasubramaniam, Ambikaipakan</creatorcontrib><title>The role of polyamines in glucagon-like peptide-2 prevention of TPN-induced gut hypoplasia</title><title>Peptides (New York, N.Y. : 1980)</title><addtitle>Peptides</addtitle><description>Total parenteral nutrition (TPN) of rats has been demonstrated to produce hypoplasia of gut mucosa, and to be associated with reduced immune response and elevated translocation of bacteria from gut to mesenteric lymph nodes, spleen and liver. Treatment of rats being maintained on TPN with the proglucagon fragment, glucagon-like peptide-2 (GLP-2), has been shown to totally prevent small intestine mucosal hypoplasia. In the present study, we found that depletion of polyamines with α-difluromethylornithine (DFMO) significantly reduced the efficacy of GLP-2 in preserving gut mucosa in rats maintained on TPN for 8 days. Co-infusion of GLP-2 with TPN prevented loss of protein and mucosa in duodenum, jejunum and ileum, but not in colon. Addition of DFMO to the infusate prevented the protective effects of GLP-2 in the duodenum and jejunum. In the jejunum, putrescine and spermidine were reduced in DFMO-treated rats, while the ileum exhibited reductions of these polyamines in rats infused with TPN or TPN plus GLP-2. DFMO infusion further reduced these polyamines in the ileum, while levels of spermine were increased. Concentrations of ornithine decarboxylase were elevated in jejunum of rats infused with TPN or TPN plus GLP-2, but were reduced significantly in DFMO-treated rats. These results suggest that normal levels of polyamines are necessary for the expression of GLP-2-induced hyperplasia. Differential effects of GLP-2 and DFMO across gut segments may relate to regional differences in proliferative and anti-apoptotic effects of the treatments.</description><subject>Animal Feed</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>DFMO</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Glucagon-Like Peptide 2</subject><subject>Glucagon-Like Peptides - administration & dosage</subject><subject>Glucagon-Like Peptides - pharmacology</subject><subject>Hypoplasia</subject><subject>Intestine, Large - abnormalities</subject><subject>Intestine, Large - anatomy & histology</subject><subject>Intestine, Large - drug effects</subject><subject>Intestine, Small - abnormalities</subject><subject>Intestine, Small - anatomy & histology</subject><subject>Intestine, Small - drug effects</subject><subject>Male</subject><subject>Organ Size</subject><subject>Ornithine decarboxylase</subject><subject>Parenteral Nutrition, Total - adverse effects</subject><subject>Polyamines - administration & dosage</subject><subject>Polyamines - pharmacology</subject><subject>Rats</subject><subject>Rats, Inbred F344</subject><subject>Small intestine</subject><subject>Vertebrates: endocrinology</subject><issn>0196-9781</issn><issn>1873-5169</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1v1DAQhi0EokvhL1S5wC1hxuvY8Q1UlQ-pAg574mI5zmTrJWsHO6m0_56sNqjHnmYOz_vO6GHsBqFCQPnxUI00Tr6jXHGAugJdAfIXbION2pY1Sv2SbQC1LLVq8Iq9yfkAAELo5jW7QsmVaGqxYb93D1SkOFAR-2KMw8kefaBc-FDsh9nZfQzl4P9QsZ4reTEmeqQw-RjOmd2vH6UP3eyoK_bzVDycxjgONnv7lr3q7ZDp3Tqv2e7L3e72W3n_8-v328_3pRNcTSW2vRagVItkoWl7UWuJ2G2hq1sUum4dd8uGJGRPqLiEBlqNWAsB0srtNftwqR1T_DtTnszRZ0fDYAPFORupGq50vX0W5NBIVFItoLyALsWcE_VmTP5o08kgmLN9czD_7ZuzfQPaLPaX4M16YW6P1D3FVt0L8H4FbHZ26JMNzucnTkkJWp6LPl04Wrw9ekomO09hcewTucl00T_3yz8GIKWo</recordid><startdate>20060401</startdate><enddate>20060401</enddate><creator>Chance, William T.</creator><creator>Sheriff, Sulaiman</creator><creator>Dayal, Ramesh</creator><creator>Friend, Lou Ann</creator><creator>Thomas, Ingrid</creator><creator>Balasubramaniam, Ambikaipakan</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>20060401</creationdate><title>The role of polyamines in glucagon-like peptide-2 prevention of TPN-induced gut hypoplasia</title><author>Chance, William T. ; Sheriff, Sulaiman ; Dayal, Ramesh ; Friend, Lou Ann ; Thomas, Ingrid ; Balasubramaniam, Ambikaipakan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c427t-1bf94077b1ea08bf459611d30d5b1495bc2c5b11e46fe1726080b91154406a63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Animal Feed</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>DFMO</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Glucagon-Like Peptide 2</topic><topic>Glucagon-Like Peptides - administration & dosage</topic><topic>Glucagon-Like Peptides - pharmacology</topic><topic>Hypoplasia</topic><topic>Intestine, Large - abnormalities</topic><topic>Intestine, Large - anatomy & histology</topic><topic>Intestine, Large - drug effects</topic><topic>Intestine, Small - abnormalities</topic><topic>Intestine, Small - anatomy & histology</topic><topic>Intestine, Small - drug effects</topic><topic>Male</topic><topic>Organ Size</topic><topic>Ornithine decarboxylase</topic><topic>Parenteral Nutrition, Total - adverse effects</topic><topic>Polyamines - administration & dosage</topic><topic>Polyamines - pharmacology</topic><topic>Rats</topic><topic>Rats, Inbred F344</topic><topic>Small intestine</topic><topic>Vertebrates: endocrinology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chance, William T.</creatorcontrib><creatorcontrib>Sheriff, Sulaiman</creatorcontrib><creatorcontrib>Dayal, Ramesh</creatorcontrib><creatorcontrib>Friend, Lou Ann</creatorcontrib><creatorcontrib>Thomas, Ingrid</creatorcontrib><creatorcontrib>Balasubramaniam, Ambikaipakan</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>Peptides (New York, N.Y. : 1980)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chance, William T.</au><au>Sheriff, Sulaiman</au><au>Dayal, Ramesh</au><au>Friend, Lou Ann</au><au>Thomas, Ingrid</au><au>Balasubramaniam, Ambikaipakan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The role of polyamines in glucagon-like peptide-2 prevention of TPN-induced gut hypoplasia</atitle><jtitle>Peptides (New York, N.Y. : 1980)</jtitle><addtitle>Peptides</addtitle><date>2006-04-01</date><risdate>2006</risdate><volume>27</volume><issue>4</issue><spage>883</spage><epage>892</epage><pages>883-892</pages><issn>0196-9781</issn><eissn>1873-5169</eissn><coden>PPTDD5</coden><abstract>Total parenteral nutrition (TPN) of rats has been demonstrated to produce hypoplasia of gut mucosa, and to be associated with reduced immune response and elevated translocation of bacteria from gut to mesenteric lymph nodes, spleen and liver. Treatment of rats being maintained on TPN with the proglucagon fragment, glucagon-like peptide-2 (GLP-2), has been shown to totally prevent small intestine mucosal hypoplasia. In the present study, we found that depletion of polyamines with α-difluromethylornithine (DFMO) significantly reduced the efficacy of GLP-2 in preserving gut mucosa in rats maintained on TPN for 8 days. Co-infusion of GLP-2 with TPN prevented loss of protein and mucosa in duodenum, jejunum and ileum, but not in colon. Addition of DFMO to the infusate prevented the protective effects of GLP-2 in the duodenum and jejunum. In the jejunum, putrescine and spermidine were reduced in DFMO-treated rats, while the ileum exhibited reductions of these polyamines in rats infused with TPN or TPN plus GLP-2. DFMO infusion further reduced these polyamines in the ileum, while levels of spermine were increased. Concentrations of ornithine decarboxylase were elevated in jejunum of rats infused with TPN or TPN plus GLP-2, but were reduced significantly in DFMO-treated rats. These results suggest that normal levels of polyamines are necessary for the expression of GLP-2-induced hyperplasia. Differential effects of GLP-2 and DFMO across gut segments may relate to regional differences in proliferative and anti-apoptotic effects of the treatments.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>16274854</pmid><doi>10.1016/j.peptides.2005.09.012</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0196-9781 |
| ispartof | Peptides (New York, N.Y. : 1980), 2006-04, Vol.27 (4), p.883-892 |
| issn | 0196-9781 1873-5169 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_67827953 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animal Feed Animals Biological and medical sciences DFMO Fundamental and applied biological sciences. Psychology Glucagon-Like Peptide 2 Glucagon-Like Peptides - administration & dosage Glucagon-Like Peptides - pharmacology Hypoplasia Intestine, Large - abnormalities Intestine, Large - anatomy & histology Intestine, Large - drug effects Intestine, Small - abnormalities Intestine, Small - anatomy & histology Intestine, Small - drug effects Male Organ Size Ornithine decarboxylase Parenteral Nutrition, Total - adverse effects Polyamines - administration & dosage Polyamines - pharmacology Rats Rats, Inbred F344 Small intestine Vertebrates: endocrinology |
| title | The role of polyamines in glucagon-like peptide-2 prevention of TPN-induced gut hypoplasia |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-08T20%3A53%3A17IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20role%20of%20polyamines%20in%20glucagon-like%20peptide-2%20prevention%20of%20TPN-induced%20gut%20hypoplasia&rft.jtitle=Peptides%20(New%20York,%20N.Y.%20:%201980)&rft.au=Chance,%20William%20T.&rft.date=2006-04-01&rft.volume=27&rft.issue=4&rft.spage=883&rft.epage=892&rft.pages=883-892&rft.issn=0196-9781&rft.eissn=1873-5169&rft.coden=PPTDD5&rft_id=info:doi/10.1016/j.peptides.2005.09.012&rft_dat=%3Cproquest_cross%3E67827953%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=20861767&rft_id=info:pmid/16274854&rft_els_id=S0196978105004663&rfr_iscdi=true |