Follicular sterol composition in gonadotrophin stimulated women with polycystic ovarian syndrome
This is the first study evaluating whether oocyte development and fertilization competence are related to intrafollicular concentration of cholesterol, meiosis-activating sterols and progesterone, after human chorionic gonadotrophin (HCG) administration of women with polycystic ovarian syndrome (PCO...
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| Veröffentlicht in: | Molecular and cellular endocrinology 2006-04, Vol.249 (1-2), p.92-98 |
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| container_title | Molecular and cellular endocrinology |
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| creator | Bokal, E. Vrtačnik Tacer, K. Fon Vrbnjak, M. Lepoša, S. Klun, I. Virant Verdenik, I. Rozman, D. |
| description | This is the first study evaluating whether oocyte development and fertilization competence are related to intrafollicular concentration of cholesterol, meiosis-activating sterols and progesterone, after human chorionic gonadotrophin (HCG) administration of women with polycystic ovarian syndrome (PCOS). The concentration of follicular fluid meiosis-activating sterol (FF-MAS) significantly increased in the periovulatory period from 10–14 to 34–38h after HCG administration, while the concentration of testis meiosis-activating sterol (T-MAS) decreased, suggesting a HCG-dependent inhibition of sterol Δ14-reductase. There was no correlation between follicular lanosterol, FF-MAS, T-MAS, and progesterone concentrations and the presence or absence of MII oocytes. Interestingly, free cholesterol level was significantly lower and FF-MAS/cholesterol and progesterone/cholesterol ratios significantly higher in follicles containing MII oocytes compared to follicles from which oocytes were not retrieved. Yet, fertilization and embryo quality did not correlate with follicular sterols. This knowledge should be beneficial for the implementation of protocols for in vitro maturation process, usually used in PCOS patients. |
| doi_str_mv | 10.1016/j.mce.2006.01.013 |
| format | Article |
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There was no correlation between follicular lanosterol, FF-MAS, T-MAS, and progesterone concentrations and the presence or absence of MII oocytes. Interestingly, free cholesterol level was significantly lower and FF-MAS/cholesterol and progesterone/cholesterol ratios significantly higher in follicles containing MII oocytes compared to follicles from which oocytes were not retrieved. Yet, fertilization and embryo quality did not correlate with follicular sterols. 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Vrtačnik</creatorcontrib><creatorcontrib>Tacer, K. Fon</creatorcontrib><creatorcontrib>Vrbnjak, M.</creatorcontrib><creatorcontrib>Lepoša, S.</creatorcontrib><creatorcontrib>Klun, I. Virant</creatorcontrib><creatorcontrib>Verdenik, I.</creatorcontrib><creatorcontrib>Rozman, D.</creatorcontrib><title>Follicular sterol composition in gonadotrophin stimulated women with polycystic ovarian syndrome</title><title>Molecular and cellular endocrinology</title><addtitle>Mol Cell Endocrinol</addtitle><description>This is the first study evaluating whether oocyte development and fertilization competence are related to intrafollicular concentration of cholesterol, meiosis-activating sterols and progesterone, after human chorionic gonadotrophin (HCG) administration of women with polycystic ovarian syndrome (PCOS). The concentration of follicular fluid meiosis-activating sterol (FF-MAS) significantly increased in the periovulatory period from 10–14 to 34–38h after HCG administration, while the concentration of testis meiosis-activating sterol (T-MAS) decreased, suggesting a HCG-dependent inhibition of sterol Δ14-reductase. There was no correlation between follicular lanosterol, FF-MAS, T-MAS, and progesterone concentrations and the presence or absence of MII oocytes. Interestingly, free cholesterol level was significantly lower and FF-MAS/cholesterol and progesterone/cholesterol ratios significantly higher in follicles containing MII oocytes compared to follicles from which oocytes were not retrieved. Yet, fertilization and embryo quality did not correlate with follicular sterols. This knowledge should be beneficial for the implementation of protocols for in vitro maturation process, usually used in PCOS patients.</description><subject>Cholestadienols - chemistry</subject><subject>Cholestadienols - metabolism</subject><subject>Cholestenes - chemistry</subject><subject>Cholestenes - metabolism</subject><subject>Cholesterol</subject><subject>Cholesterol - metabolism</subject><subject>Chorionic Gonadotropin - pharmacology</subject><subject>Embryonic Development</subject><subject>Female</subject><subject>Fertilization in Vitro</subject><subject>Follicular fluid meiosis-activating sterol (FF-MAS)</subject><subject>Humans</subject><subject>In vitro fertilization (IVF)</subject><subject>Lanosterol - metabolism</subject><subject>Metaphase</subject><subject>Oocyte</subject><subject>Oocytes - cytology</subject><subject>Ovarian Follicle - drug effects</subject><subject>Ovarian Follicle - metabolism</subject><subject>Ovulation Induction</subject><subject>Polycystic Ovary Syndrome - metabolism</subject><subject>Progesterone - metabolism</subject><issn>0303-7207</issn><issn>1872-8057</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEFLAzEQhYMotlZ_gBfZk7etk2Q3u8WTFKtCwYueY0xmNWV3sybZSv-9kRa8CQPDMN978B4hlxTmFKi42cw7jXMGIOZA0_AjMqV1xfIayuqYTIEDzysG1YSchbABgKpk9SmZUFFSwatiSt5Wrm2tHlvlsxDRuzbTrhtcsNG6PrN99uF6ZVz0bvhMV4i2S3BEk327Dvvs28bPbHDtTu_ST2duq7xVCdz1xifinJw0qg14cdgz8rq6f1k-5uvnh6fl3TrXvKQxfzeoDC2x1k1TgKGGc2UEaigYa0TKAXVZNFwvDAXFOROs4Y0wutYFW1S85DNyvfcdvPsaMUTZ2aCxbVWPbgxSVDUTdTKaEboHtXcheGzk4G2n_E5SkL-1yo1MtcrfWiXQNDxprg7m43uH5k9x6DEBt3sAU8StRS-DtthrNNajjtI4-4_9DxqyisI</recordid><startdate>20060425</startdate><enddate>20060425</enddate><creator>Bokal, E. 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Vrtačnik</creatorcontrib><creatorcontrib>Tacer, K. Fon</creatorcontrib><creatorcontrib>Vrbnjak, M.</creatorcontrib><creatorcontrib>Lepoša, S.</creatorcontrib><creatorcontrib>Klun, I. Virant</creatorcontrib><creatorcontrib>Verdenik, I.</creatorcontrib><creatorcontrib>Rozman, D.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Molecular and cellular endocrinology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bokal, E. Vrtačnik</au><au>Tacer, K. Fon</au><au>Vrbnjak, M.</au><au>Lepoša, S.</au><au>Klun, I. 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| ispartof | Molecular and cellular endocrinology, 2006-04, Vol.249 (1-2), p.92-98 |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Cholestadienols - chemistry Cholestadienols - metabolism Cholestenes - chemistry Cholestenes - metabolism Cholesterol Cholesterol - metabolism Chorionic Gonadotropin - pharmacology Embryonic Development Female Fertilization in Vitro Follicular fluid meiosis-activating sterol (FF-MAS) Humans In vitro fertilization (IVF) Lanosterol - metabolism Metaphase Oocyte Oocytes - cytology Ovarian Follicle - drug effects Ovarian Follicle - metabolism Ovulation Induction Polycystic Ovary Syndrome - metabolism Progesterone - metabolism |
| title | Follicular sterol composition in gonadotrophin stimulated women with polycystic ovarian syndrome |
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