Intrapulmonary application of a 5-lipoxygenase inhibitor using surfactant as a carrier reduces lung edema in a piglet model of airway lavage

Leukotriene‐generated effects on microvascular integrity and polymorphonuclear leukocytes (PMNL) play a key role in the inflammatory process of the alveolar‐capillary unit in neonatal acute respiratory distress syndrome. We asked if intrapulmonary application of MK886, a 5‐lipoxygenase inhibitor, an...

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Veröffentlicht in:	Pediatric pulmonology 2006-05, Vol.41 (5), p.452-462
Hauptverfasser:	Ankermann, Tobias, Reisner, Anja, Wiemann, Tina, Koehler, Heike, Krams, Matthias, Krause, Martin F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn Biological and medical sciences Biological Products Bronchoalveolar Lavage Fluid - chemistry Bronchoalveolar Lavage Fluid - cytology Disease Models, Animal Female Hemodynamics Humans Indoles - administration & dosage Indoles - therapeutic use Infant, Newborn Interleukin-8 - analysis leukotriene B4 Leukotriene B4 - metabolism Lipoxygenase Inhibitors - administration & dosage Lipoxygenase Inhibitors - therapeutic use Lung - drug effects Lung - metabolism lung edema lung function Male Medical sciences MK886 neonatal acute respiratory distress syndrome Phospholipids Pneumology Pulmonary Edema - drug therapy Pulmonary Edema - prevention & control Pulmonary Gas Exchange - drug effects Respiration, Artificial Respiratory Distress Syndrome, Newborn - physiopathology Respiratory system : syndromes and miscellaneous diseases surfactant Swine
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