Study of serum amyloid A concentrations as a means of achieving early diagnosis of Rhodococcus equi pneumonia

Summary Reasons for performing study: Prognosis of Rhodococcus equi pneumonia can be challenging because the course of the disease is often insidious and overt clinical signs are subtle. Early diagnosis is considered desirable because it may offer the chance of more successful implementation of trea...

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Veröffentlicht in:Equine veterinary journal 2005-05, Vol.37 (3), p.212-216
Hauptverfasser: Cohen, N.D, Chaffin, M.K, Vandenplas, M.L, Edwards, R.F, Nevill, M, Moore, J.N, Martens, R.J
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container_end_page 216
container_issue 3
container_start_page 212
container_title Equine veterinary journal
container_volume 37
creator Cohen, N.D
Chaffin, M.K
Vandenplas, M.L
Edwards, R.F
Nevill, M
Moore, J.N
Martens, R.J
description Summary Reasons for performing study: Prognosis of Rhodococcus equi pneumonia can be challenging because the course of the disease is often insidious and overt clinical signs are subtle. Early diagnosis is considered desirable because it may offer the chance of more successful implementation of treatment and, thereby, improved outcome. Serological tests have previously failed to be accurate for early detection or diagnosis. Measurement of serum amyloid A (SAA) prior to and at the time of clinical signs was therefore chosen in order to assess its potential clinical use. Objective: To determine whether SAA concentrations differentiate foals affected with R. equi pneumonia from unaffected foals, either prior to the onset of disease or at the time of onset of clinical signs. Hypothesis: SAA concentrations are significantly higher among foals that develop R. equi pneumonia than in foals from the same environment that remain clinically unaffected. Methods: Serum samples were obtained from 212 foals 7–14 days and 196 foals 21–28 days post partum, and from affected foals and age‐matched controls at the time of onset of signs of pneumonia. SAA concentration was determined for each sample. Results: There were no significant differences between SAA concentrations of foals with R. equi and clinically unaffected foals during the 2 periods of examination or at the time of onset of clinical signs of R. equi pneumonia. Conclusions: Concentrations of SAA are variable among foals with R. equi pneumonia and cannot be used reliably either as an ancillary diagnostic tool or to screen for early detection of disease during the first month post partum. Potential relevance: Bimonthly monitoring concentration of SAA is not useful as a screening test for early detection of R. equi pneumonia and does not facilitate diagnosis of this disease when used according to the protocol of this study.
doi_str_mv 10.2746/0425164054530704
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Early diagnosis is considered desirable because it may offer the chance of more successful implementation of treatment and, thereby, improved outcome. Serological tests have previously failed to be accurate for early detection or diagnosis. Measurement of serum amyloid A (SAA) prior to and at the time of clinical signs was therefore chosen in order to assess its potential clinical use. Objective: To determine whether SAA concentrations differentiate foals affected with R. equi pneumonia from unaffected foals, either prior to the onset of disease or at the time of onset of clinical signs. Hypothesis: SAA concentrations are significantly higher among foals that develop R. equi pneumonia than in foals from the same environment that remain clinically unaffected. Methods: Serum samples were obtained from 212 foals 7–14 days and 196 foals 21–28 days post partum, and from affected foals and age‐matched controls at the time of onset of signs of pneumonia. SAA concentration was determined for each sample. Results: There were no significant differences between SAA concentrations of foals with R. equi and clinically unaffected foals during the 2 periods of examination or at the time of onset of clinical signs of R. equi pneumonia. Conclusions: Concentrations of SAA are variable among foals with R. equi pneumonia and cannot be used reliably either as an ancillary diagnostic tool or to screen for early detection of disease during the first month post partum. Potential relevance: Bimonthly monitoring concentration of SAA is not useful as a screening test for early detection of R. equi pneumonia and does not facilitate diagnosis of this disease when used according to the protocol of this study.</description><identifier>ISSN: 0425-1644</identifier><identifier>EISSN: 2042-3306</identifier><identifier>DOI: 10.2746/0425164054530704</identifier><identifier>PMID: 15892228</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Actinomycetales Infections - blood ; Actinomycetales Infections - diagnosis ; Actinomycetales Infections - veterinary ; Aging - blood ; Animals ; Animals, Newborn - blood ; bacterial pneumonia ; biomarkers ; blood serum ; chemical concentration ; diagnosis ; Diagnosis, Differential ; disease course ; disease detection ; disease diagnosis ; foals ; horse ; horse diseases ; Horse Diseases - blood ; Horse Diseases - diagnosis ; Horses ; Pneumonia, Bacterial - blood ; Pneumonia, Bacterial - diagnosis ; Pneumonia, Bacterial - veterinary ; Predictive Value of Tests ; Prognosis ; protein aggregates ; reliability ; Rhodococcus equi ; screening ; Sensitivity and Specificity ; serum amyloid A ; Serum Amyloid A Protein - analysis ; symptoms</subject><ispartof>Equine veterinary journal, 2005-05, Vol.37 (3), p.212-216</ispartof><rights>2005 EVJ Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4040-5689f56dadd1c8a827b5e3535944deee5b99ddc28e1db70cfd1babe83a82a4d53</citedby><cites>FETCH-LOGICAL-c4040-5689f56dadd1c8a827b5e3535944deee5b99ddc28e1db70cfd1babe83a82a4d53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.2746%2F0425164054530704$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.2746%2F0425164054530704$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,781,785,1418,27929,27930,45579,45580</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15892228$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cohen, N.D</creatorcontrib><creatorcontrib>Chaffin, M.K</creatorcontrib><creatorcontrib>Vandenplas, M.L</creatorcontrib><creatorcontrib>Edwards, R.F</creatorcontrib><creatorcontrib>Nevill, M</creatorcontrib><creatorcontrib>Moore, J.N</creatorcontrib><creatorcontrib>Martens, R.J</creatorcontrib><title>Study of serum amyloid A concentrations as a means of achieving early diagnosis of Rhodococcus equi pneumonia</title><title>Equine veterinary journal</title><addtitle>Equine Vet J</addtitle><description>Summary Reasons for performing study: Prognosis of Rhodococcus equi pneumonia can be challenging because the course of the disease is often insidious and overt clinical signs are subtle. Early diagnosis is considered desirable because it may offer the chance of more successful implementation of treatment and, thereby, improved outcome. Serological tests have previously failed to be accurate for early detection or diagnosis. Measurement of serum amyloid A (SAA) prior to and at the time of clinical signs was therefore chosen in order to assess its potential clinical use. Objective: To determine whether SAA concentrations differentiate foals affected with R. equi pneumonia from unaffected foals, either prior to the onset of disease or at the time of onset of clinical signs. Hypothesis: SAA concentrations are significantly higher among foals that develop R. equi pneumonia than in foals from the same environment that remain clinically unaffected. Methods: Serum samples were obtained from 212 foals 7–14 days and 196 foals 21–28 days post partum, and from affected foals and age‐matched controls at the time of onset of signs of pneumonia. SAA concentration was determined for each sample. Results: There were no significant differences between SAA concentrations of foals with R. equi and clinically unaffected foals during the 2 periods of examination or at the time of onset of clinical signs of R. equi pneumonia. Conclusions: Concentrations of SAA are variable among foals with R. equi pneumonia and cannot be used reliably either as an ancillary diagnostic tool or to screen for early detection of disease during the first month post partum. 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Chaffin, M.K ; Vandenplas, M.L ; Edwards, R.F ; Nevill, M ; Moore, J.N ; Martens, R.J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4040-5689f56dadd1c8a827b5e3535944deee5b99ddc28e1db70cfd1babe83a82a4d53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Actinomycetales Infections - blood</topic><topic>Actinomycetales Infections - diagnosis</topic><topic>Actinomycetales Infections - veterinary</topic><topic>Aging - blood</topic><topic>Animals</topic><topic>Animals, Newborn - blood</topic><topic>bacterial pneumonia</topic><topic>biomarkers</topic><topic>blood serum</topic><topic>chemical concentration</topic><topic>diagnosis</topic><topic>Diagnosis, Differential</topic><topic>disease course</topic><topic>disease detection</topic><topic>disease diagnosis</topic><topic>foals</topic><topic>horse</topic><topic>horse diseases</topic><topic>Horse Diseases - blood</topic><topic>Horse Diseases - diagnosis</topic><topic>Horses</topic><topic>Pneumonia, Bacterial - blood</topic><topic>Pneumonia, Bacterial - diagnosis</topic><topic>Pneumonia, Bacterial - veterinary</topic><topic>Predictive Value of Tests</topic><topic>Prognosis</topic><topic>protein aggregates</topic><topic>reliability</topic><topic>Rhodococcus equi</topic><topic>screening</topic><topic>Sensitivity and Specificity</topic><topic>serum amyloid A</topic><topic>Serum Amyloid A Protein - analysis</topic><topic>symptoms</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cohen, N.D</creatorcontrib><creatorcontrib>Chaffin, M.K</creatorcontrib><creatorcontrib>Vandenplas, M.L</creatorcontrib><creatorcontrib>Edwards, R.F</creatorcontrib><creatorcontrib>Nevill, M</creatorcontrib><creatorcontrib>Moore, J.N</creatorcontrib><creatorcontrib>Martens, R.J</creatorcontrib><collection>AGRIS</collection><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Equine veterinary journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cohen, N.D</au><au>Chaffin, M.K</au><au>Vandenplas, M.L</au><au>Edwards, R.F</au><au>Nevill, M</au><au>Moore, J.N</au><au>Martens, R.J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Study of serum amyloid A concentrations as a means of achieving early diagnosis of Rhodococcus equi pneumonia</atitle><jtitle>Equine veterinary journal</jtitle><addtitle>Equine Vet J</addtitle><date>2005-05</date><risdate>2005</risdate><volume>37</volume><issue>3</issue><spage>212</spage><epage>216</epage><pages>212-216</pages><issn>0425-1644</issn><eissn>2042-3306</eissn><abstract>Summary Reasons for performing study: Prognosis of Rhodococcus equi pneumonia can be challenging because the course of the disease is often insidious and overt clinical signs are subtle. Early diagnosis is considered desirable because it may offer the chance of more successful implementation of treatment and, thereby, improved outcome. Serological tests have previously failed to be accurate for early detection or diagnosis. Measurement of serum amyloid A (SAA) prior to and at the time of clinical signs was therefore chosen in order to assess its potential clinical use. Objective: To determine whether SAA concentrations differentiate foals affected with R. equi pneumonia from unaffected foals, either prior to the onset of disease or at the time of onset of clinical signs. Hypothesis: SAA concentrations are significantly higher among foals that develop R. equi pneumonia than in foals from the same environment that remain clinically unaffected. Methods: Serum samples were obtained from 212 foals 7–14 days and 196 foals 21–28 days post partum, and from affected foals and age‐matched controls at the time of onset of signs of pneumonia. SAA concentration was determined for each sample. Results: There were no significant differences between SAA concentrations of foals with R. equi and clinically unaffected foals during the 2 periods of examination or at the time of onset of clinical signs of R. equi pneumonia. Conclusions: Concentrations of SAA are variable among foals with R. equi pneumonia and cannot be used reliably either as an ancillary diagnostic tool or to screen for early detection of disease during the first month post partum. Potential relevance: Bimonthly monitoring concentration of SAA is not useful as a screening test for early detection of R. equi pneumonia and does not facilitate diagnosis of this disease when used according to the protocol of this study.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>15892228</pmid><doi>10.2746/0425164054530704</doi><tpages>5</tpages></addata></record>
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subjects Actinomycetales Infections - blood
Actinomycetales Infections - diagnosis
Actinomycetales Infections - veterinary
Aging - blood
Animals
Animals, Newborn - blood
bacterial pneumonia
biomarkers
blood serum
chemical concentration
diagnosis
Diagnosis, Differential
disease course
disease detection
disease diagnosis
foals
horse
horse diseases
Horse Diseases - blood
Horse Diseases - diagnosis
Horses
Pneumonia, Bacterial - blood
Pneumonia, Bacterial - diagnosis
Pneumonia, Bacterial - veterinary
Predictive Value of Tests
Prognosis
protein aggregates
reliability
Rhodococcus equi
screening
Sensitivity and Specificity
serum amyloid A
Serum Amyloid A Protein - analysis
symptoms
title Study of serum amyloid A concentrations as a means of achieving early diagnosis of Rhodococcus equi pneumonia
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