Effect of Metabotropic Glutamate Receptor 3 Genotype on N -Acetylaspartate Measures in the Dorsolateral Prefrontal Cortex

Objective: This study was carried out to confirm prior evidence of an effect of a single nucleotide polymorphism (SNP) in the metabotropic glutamate receptor 3 (GRM3) gene (a putative risk factor for schizophrenia) on measures of N -acetylaspartate in healthy comparison subjects. Method: Fifty-four...

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Veröffentlicht in:	The American journal of psychiatry 2006-04, Vol.163 (4), p.740-742
Hauptverfasser:	Marenco, Stefano, Steele, Sonya U., Egan, Michael F., Goldberg, Terry E., Straub, Richard E., Sharrief, Anjail Z., Weinberger, Daniel R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Anatomical correlates of behavior Aspartic Acid - analogs & derivatives Aspartic Acid - analysis Aspartic Acid - metabolism Behavioral psychophysiology Biological and medical sciences Brain Creatine - analysis Female Functional Laterality - physiology Fundamental and applied biological sciences. Psychology Genes Genetic Predisposition to Disease Genotype Genotype & phenotype Heterozygote Humans Introns - genetics Introns - physiology Magnetic Resonance Spectroscopy Male Neuropsychological Tests NMR Nuclear magnetic resonance Polymorphism, Single Nucleotide - genetics Polymorphism, Single Nucleotide - physiology Prefrontal Cortex - chemistry Prefrontal Cortex - metabolism Prefrontal Cortex - physiopathology Psychiatric Status Rating Scales - statistics & numerical data Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Receptors, Metabotropic Glutamate - genetics Receptors, Metabotropic Glutamate - metabolism Receptors, Metabotropic Glutamate - physiology Risk factors Schizophrenia Schizophrenia - diagnosis Schizophrenia - genetics Schizophrenia - physiopathology
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