Decreased NK cell frequency in chronic hepatitis C does not affect ex vivo cytolytic killing
Prior studies have suggested that natural killer (NK) cell function might be impaired in chronic hepatitis C virus (HCV) infection. Circulating NK cell frequency and cytolytic activity were examined freshly ex vivo in HCV-infected and uninfected subjects. Surprisingly, the intrinsic cytolytic activi...
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| Veröffentlicht in: | Hepatology (Baltimore, Md.) Md.), 2006-03, Vol.43 (3), p.573-580 |
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| container_title | Hepatology (Baltimore, Md.) |
| container_volume | 43 |
| creator | MORISHIMA, Chihiro PASCHAL, Denise M WANG, Chia C YOSHIHARA, Christina S WOOD, Brent L YEO, Anthony E. T EMERSON, Scott S SHUHART, Margaret C GRETCH, David R |
| description | Prior studies have suggested that natural killer (NK) cell function might be impaired in chronic hepatitis C virus (HCV) infection. Circulating NK cell frequency and cytolytic activity were examined freshly ex vivo in HCV-infected and uninfected subjects. Surprisingly, the intrinsic cytolytic activity of peripheral blood NK-enriched cells was similar between HCV-infected and uninfected groups (P = .91). Although the percentage of circulating CD3- CD16/56+ NK cells was 30% lower in HCV-infected compared with uninfected subjects (P = .02) paralleled by a decrease of CD56(dim) cytolytic NK cells (P = .02), overall K562 cytolysis by unfractionated peripheral blood mononuclear cells was not affected (P = .29). Analysis of the relationships between NK cytolytic activity and other clinical information revealed an inverse association with liver fibrosis stage (P = .035). In conclusion, NK cell cytolytic function does not appear to be impaired in chronic hepatitis C, but higher levels of NK cell cytolysis are associated with less liver fibrosis. |
| doi_str_mv | 10.1002/hep.21073 |
| format | Article |
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Although the percentage of circulating CD3- CD16/56+ NK cells was 30% lower in HCV-infected compared with uninfected subjects (P = .02) paralleled by a decrease of CD56(dim) cytolytic NK cells (P = .02), overall K562 cytolysis by unfractionated peripheral blood mononuclear cells was not affected (P = .29). Analysis of the relationships between NK cytolytic activity and other clinical information revealed an inverse association with liver fibrosis stage (P = .035). In conclusion, NK cell cytolytic function does not appear to be impaired in chronic hepatitis C, but higher levels of NK cell cytolysis are associated with less liver fibrosis.</description><identifier>ISSN: 0270-9139</identifier><identifier>EISSN: 1527-3350</identifier><identifier>DOI: 10.1002/hep.21073</identifier><identifier>PMID: 16496327</identifier><identifier>CODEN: HPTLD9</identifier><language>eng</language><publisher>Hoboken, NJ: Wiley</publisher><subject>Adult ; Biological and medical sciences ; Cytotoxicity, Immunologic - immunology ; Female ; Gastroenterology. Liver. Pancreas. 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Although the percentage of circulating CD3- CD16/56+ NK cells was 30% lower in HCV-infected compared with uninfected subjects (P = .02) paralleled by a decrease of CD56(dim) cytolytic NK cells (P = .02), overall K562 cytolysis by unfractionated peripheral blood mononuclear cells was not affected (P = .29). Analysis of the relationships between NK cytolytic activity and other clinical information revealed an inverse association with liver fibrosis stage (P = .035). In conclusion, NK cell cytolytic function does not appear to be impaired in chronic hepatitis C, but higher levels of NK cell cytolysis are associated with less liver fibrosis.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Cytotoxicity, Immunologic - immunology</subject><subject>Female</subject><subject>Gastroenterology. Liver. Pancreas. 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Although the percentage of circulating CD3- CD16/56+ NK cells was 30% lower in HCV-infected compared with uninfected subjects (P = .02) paralleled by a decrease of CD56(dim) cytolytic NK cells (P = .02), overall K562 cytolysis by unfractionated peripheral blood mononuclear cells was not affected (P = .29). Analysis of the relationships between NK cytolytic activity and other clinical information revealed an inverse association with liver fibrosis stage (P = .035). In conclusion, NK cell cytolytic function does not appear to be impaired in chronic hepatitis C, but higher levels of NK cell cytolysis are associated with less liver fibrosis.</abstract><cop>Hoboken, NJ</cop><pub>Wiley</pub><pmid>16496327</pmid><doi>10.1002/hep.21073</doi><tpages>8</tpages></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; EZB-FREE-00999 freely available EZB journals |
| subjects | Adult Biological and medical sciences Cytotoxicity, Immunologic - immunology Female Gastroenterology. Liver. Pancreas. Abdomen Hepatitis C, Chronic - immunology Human viral diseases Humans Infectious diseases Killer Cells, Natural - immunology Liver Cirrhosis - immunology Lymphocyte Count Lymphocyte Subsets - immunology Male Medical sciences Viral diseases Viral hepatitis |
| title | Decreased NK cell frequency in chronic hepatitis C does not affect ex vivo cytolytic killing |
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