Signal transducer and activator of transcription 1 activation in endothelial cells is a negative regulator of angiogenesis

To determine the role of the transcription factor signal transducer and activator of transcription (STAT) 1 on endothelial cell function, human umbilical vein endothelial cells (HUVEC) were treated with IFN-gamma, a potent activator of STAT1. IFN-gamma inhibited cell growth and tube formation of HUV...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2006-04, Vol.66 (7), p.3649-3657
Hauptverfasser:	BATTLE, Traci E, LYNCH, Rebecca A, FRANK, David A
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Biological and medical sciences Cell Growth Processes - drug effects Cell Growth Processes - physiology Endothelial Cells - cytology Endothelial Cells - drug effects Humans Interferon-gamma - pharmacology Medical sciences Neovascularization, Physiologic - drug effects Neovascularization, Physiologic - physiology Pharmacology. Drug treatments Phosphorylation - drug effects Recombinant Proteins RNA, Small Interfering - genetics STAT1 Transcription Factor - antagonists & inhibitors STAT1 Transcription Factor - genetics STAT1 Transcription Factor - metabolism Transfection Tumors Vascular Endothelial Growth Factor A - antagonists & inhibitors Vascular Endothelial Growth Factor A - pharmacology Vascular Endothelial Growth Factor Receptor-2 - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!