SOX4 expression in bladder carcinoma : Clinical aspects and in vitro functional characterization

The human transcription factor SOX4 was 5-fold up-regulated in bladder tumors compared with normal tissue based on whole-genome expression profiling of 166 clinical bladder tumor samples and 27 normal urothelium samples. Using a SOX4-specific antibody, we found that the cancer cells expressed the SO...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2006-04, Vol.66 (7), p.3434-3442
Hauptverfasser:	AABOE, Mads, BIRKENKAMP-DEMTRODER, Karin, WIUF, Carsten, SØRENSEN, Flemming Brandt, THYKJAER, Thomas, SAUTER, Guido, JENSEN, Klaus Møller-Ernst, DYRSKJØT, Lars, ØRNTOFT, Torben
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Apoptosis - genetics Binding Sites Biological and medical sciences Cell Line, Tumor Gene Amplification Gene Expression Profiling Gene Expression Regulation, Neoplastic High Mobility Group Proteins - biosynthesis High Mobility Group Proteins - genetics High Mobility Group Proteins - metabolism Humans Immunohistochemistry Medical sciences Nephrology. Urinary tract diseases Oligonucleotide Array Sequence Analysis Pharmacology. Drug treatments Promoter Regions, Genetic RNA, Messenger - biosynthesis RNA, Messenger - genetics SOXC Transcription Factors Trans-Activators - biosynthesis Trans-Activators - genetics Trans-Activators - metabolism Transcriptional Activation Transfection Tumors Tumors of the urinary system Up-Regulation Urinary Bladder Neoplasms - genetics Urinary Bladder Neoplasms - metabolism Urinary system involvement in other diseases. Miscellaneous Urinary tract. Prostate gland
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