Effects of Irradiation Combined with Cis‐diamminedichloroplatinum (CDDP) Suppository in Rabbit VX2 Rectal Tumors
To decrease local recurrence and increase disease free survival, various preoperative therapies for patients with advanced rectal cancer have been studied. Cis‐diamminedichloroplatinum (II) (CDDP) has become one of the most widely used cancer chemotherapeutic drugs. It has also been found to have ra...
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| Veröffentlicht in: | World journal of surgery 2005-03, Vol.29 (3), p.388-395 |
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| creator | Wakatsuki, Kazuo Oda, Kenji Koda, Keiji Seike, Kazuhiro Takiguchi, Nobuhiro Saito, Norio Miyazaki, Masaru |
| description | To decrease local recurrence and increase disease free survival, various preoperative therapies for patients with advanced rectal cancer have been studied. Cis‐diamminedichloroplatinum (II) (CDDP) has become one of the most widely used cancer chemotherapeutic drugs. It has also been found to have radiosensitizing properties. In this experimental study, the efficacy of chemoradiotherapy using a novel CDDP suppository, and one with mixed micelles, was examined in a rabbit VX2 rectal tumor model. Rabbits were divided into four groups: control group, irradiation (R) group, CDDP suppository plus irradiation (CR) group, and mixed micelles plus CDDP suppository plus irradiation (CMR) group. Tumor growth ratios were reduced significantly in the CR and CMR groups as compared with the ratio in the control group. Microscopically, response rates of main tumors were 0%, 33.3%, 70.0%, and 91. 7%, respectively. The number of metastatic lymph nodes in the CR and CMR groups decreased significantly compared to the control group and the R group. The microscopic response rates of metastatic lymph nodes were 0%, 11.1%, 40.0%, and 41.7%, respectively. Lung metastases were observed in three rabbits in the R group, and in one rabbit in the CMR group. Tissue platinum concentrations both in tumors and in regional lymph nodes increased significantly when mixed micelles were used. Chemoradiotherapy using the CDDP suppository and mixed micelles was effective for local control in the rabbit VX2 rectal tumor model. |
| doi_str_mv | 10.1007/s00268-004-7625-8 |
| format | Article |
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Cis‐diamminedichloroplatinum (II) (CDDP) has become one of the most widely used cancer chemotherapeutic drugs. It has also been found to have radiosensitizing properties. In this experimental study, the efficacy of chemoradiotherapy using a novel CDDP suppository, and one with mixed micelles, was examined in a rabbit VX2 rectal tumor model. Rabbits were divided into four groups: control group, irradiation (R) group, CDDP suppository plus irradiation (CR) group, and mixed micelles plus CDDP suppository plus irradiation (CMR) group. Tumor growth ratios were reduced significantly in the CR and CMR groups as compared with the ratio in the control group. Microscopically, response rates of main tumors were 0%, 33.3%, 70.0%, and 91. 7%, respectively. The number of metastatic lymph nodes in the CR and CMR groups decreased significantly compared to the control group and the R group. The microscopic response rates of metastatic lymph nodes were 0%, 11.1%, 40.0%, and 41.7%, respectively. Lung metastases were observed in three rabbits in the R group, and in one rabbit in the CMR group. Tissue platinum concentrations both in tumors and in regional lymph nodes increased significantly when mixed micelles were used. Chemoradiotherapy using the CDDP suppository and mixed micelles was effective for local control in the rabbit VX2 rectal tumor model.</description><identifier>ISSN: 0364-2313</identifier><identifier>EISSN: 1432-2323</identifier><identifier>DOI: 10.1007/s00268-004-7625-8</identifier><identifier>PMID: 15706445</identifier><identifier>CODEN: WJSUDI</identifier><language>eng</language><publisher>New York: Springer‐Verlag</publisher><subject>Animals ; Antineoplastic Agents - administration & dosage ; Biological and medical sciences ; CDDP ; Cisplatin - administration & dosage ; Combined Modality Therapy ; Disease Models, Animal ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; General aspects ; Lymphatic Metastasis ; Main Tumor ; Medical sciences ; Metastatic Lymph Node ; Micelles ; Mixed Micelle ; Rabbits ; Rectal Neoplasms - drug therapy ; Rectal Neoplasms - pathology ; Rectal Neoplasms - radiotherapy ; Regional Lymph Node ; Stomach. Duodenum. Small intestine. Colon. Rectum. 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Cis‐diamminedichloroplatinum (II) (CDDP) has become one of the most widely used cancer chemotherapeutic drugs. It has also been found to have radiosensitizing properties. In this experimental study, the efficacy of chemoradiotherapy using a novel CDDP suppository, and one with mixed micelles, was examined in a rabbit VX2 rectal tumor model. Rabbits were divided into four groups: control group, irradiation (R) group, CDDP suppository plus irradiation (CR) group, and mixed micelles plus CDDP suppository plus irradiation (CMR) group. Tumor growth ratios were reduced significantly in the CR and CMR groups as compared with the ratio in the control group. Microscopically, response rates of main tumors were 0%, 33.3%, 70.0%, and 91. 7%, respectively. The number of metastatic lymph nodes in the CR and CMR groups decreased significantly compared to the control group and the R group. The microscopic response rates of metastatic lymph nodes were 0%, 11.1%, 40.0%, and 41.7%, respectively. Lung metastases were observed in three rabbits in the R group, and in one rabbit in the CMR group. Tissue platinum concentrations both in tumors and in regional lymph nodes increased significantly when mixed micelles were used. Chemoradiotherapy using the CDDP suppository and mixed micelles was effective for local control in the rabbit VX2 rectal tumor model.</description><subject>Animals</subject><subject>Antineoplastic Agents - administration & dosage</subject><subject>Biological and medical sciences</subject><subject>CDDP</subject><subject>Cisplatin - administration & dosage</subject><subject>Combined Modality Therapy</subject><subject>Disease Models, Animal</subject><subject>Female</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>General aspects</subject><subject>Lymphatic Metastasis</subject><subject>Main Tumor</subject><subject>Medical sciences</subject><subject>Metastatic Lymph Node</subject><subject>Micelles</subject><subject>Mixed Micelle</subject><subject>Rabbits</subject><subject>Rectal Neoplasms - drug therapy</subject><subject>Rectal Neoplasms - pathology</subject><subject>Rectal Neoplasms - radiotherapy</subject><subject>Regional Lymph Node</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. 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Liver. Pancreas. Abdomen</topic><topic>General aspects</topic><topic>Lymphatic Metastasis</topic><topic>Main Tumor</topic><topic>Medical sciences</topic><topic>Metastatic Lymph Node</topic><topic>Micelles</topic><topic>Mixed Micelle</topic><topic>Rabbits</topic><topic>Rectal Neoplasms - drug therapy</topic><topic>Rectal Neoplasms - pathology</topic><topic>Rectal Neoplasms - radiotherapy</topic><topic>Regional Lymph Node</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. 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Cis‐diamminedichloroplatinum (II) (CDDP) has become one of the most widely used cancer chemotherapeutic drugs. It has also been found to have radiosensitizing properties. In this experimental study, the efficacy of chemoradiotherapy using a novel CDDP suppository, and one with mixed micelles, was examined in a rabbit VX2 rectal tumor model. Rabbits were divided into four groups: control group, irradiation (R) group, CDDP suppository plus irradiation (CR) group, and mixed micelles plus CDDP suppository plus irradiation (CMR) group. Tumor growth ratios were reduced significantly in the CR and CMR groups as compared with the ratio in the control group. Microscopically, response rates of main tumors were 0%, 33.3%, 70.0%, and 91. 7%, respectively. The number of metastatic lymph nodes in the CR and CMR groups decreased significantly compared to the control group and the R group. The microscopic response rates of metastatic lymph nodes were 0%, 11.1%, 40.0%, and 41.7%, respectively. Lung metastases were observed in three rabbits in the R group, and in one rabbit in the CMR group. Tissue platinum concentrations both in tumors and in regional lymph nodes increased significantly when mixed micelles were used. Chemoradiotherapy using the CDDP suppository and mixed micelles was effective for local control in the rabbit VX2 rectal tumor model.</abstract><cop>New York</cop><pub>Springer‐Verlag</pub><pmid>15706445</pmid><doi>10.1007/s00268-004-7625-8</doi><tpages>8</tpages></addata></record> |
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| subjects | Animals Antineoplastic Agents - administration & dosage Biological and medical sciences CDDP Cisplatin - administration & dosage Combined Modality Therapy Disease Models, Animal Female Gastroenterology. Liver. Pancreas. Abdomen General aspects Lymphatic Metastasis Main Tumor Medical sciences Metastatic Lymph Node Micelles Mixed Micelle Rabbits Rectal Neoplasms - drug therapy Rectal Neoplasms - pathology Rectal Neoplasms - radiotherapy Regional Lymph Node Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Suppositories Tumors |
| title | Effects of Irradiation Combined with Cis‐diamminedichloroplatinum (CDDP) Suppository in Rabbit VX2 Rectal Tumors |
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