Formation of Pyroglutamic Acid from N-Terminal Glutamic Acid in Immunoglobulin Gamma Antibodies

The status of the N-terminus of proteins is important for amino acid sequencing by Edman degradation, protein identification by shotgun and top-down techniques, and to uncover biological functions, which may be associated with modifications. In this study, we investigated the pyroglutamic acid forma...

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Veröffentlicht in:	Analytical chemistry (Washington) 2006-04, Vol.78 (7), p.2370-2376
Hauptverfasser:	Chelius, Dirk, Jing, Kay, Lueras, Alexis, Rehder, Douglas S, Dillon, Thomas M, Vizel, Alona, Rajan, Rahul S, Li, Tiansheng, Treuheit, Michael J, Bondarenko, Pavel V
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkylation Amino Acid Sequence Amino acids Analytical chemistry Antibodies, Monoclonal - analysis Antibodies, Monoclonal - immunology Chemistry Chromatographic methods and physical methods associated with chromatography Chromatography, High Pressure Liquid - methods Exact sciences and technology Glutamic Acid - analysis Glutamic Acid - metabolism Hydrogen-Ion Concentration Immunoglobulin gamma-Chains - metabolism Immunoglobulins Molecular Sequence Data Monoclonal antibodies Other chromatographic methods Proteins Pyrrolidonecarboxylic Acid - analysis Pyrrolidonecarboxylic Acid - metabolism Spectrometric and optical methods Tandem Mass Spectrometry - methods Temperature Time Factors
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