Translocation of p21(Cip1/WAF1) from the nucleus to the cytoplasm correlates with pancreatic myofibroblast to fibroblast cell conversion

In the pancreas, myofibroblasts (MFBs) were shown to play an important role in the cellular response during inflammation and injury. However, there is only fragmentary information concerning the fate of these cells in pancreas regeneration and fibrosis development. Explant cultures of rat pancreatic...

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Veröffentlicht in:	Gut 2005-06, Vol.54 (6), p.814-822
Hauptverfasser:	Manapov, F, Muller, P, Rychly, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - physiology Blotting, Western Cell Cycle Proteins - metabolism Cell Differentiation Cell Nucleus - metabolism Cell Proliferation Cells, Cultured Cyclin-Dependent Kinase Inhibitor p21 Cytoplasm - metabolism Fibroblasts - metabolism Fibroblasts - pathology Fibrosis - metabolism Fibrosis - pathology JNK Mitogen-Activated Protein Kinases - metabolism Male MAP Kinase Kinase 4 Mitogen-Activated Protein Kinase Kinases - metabolism Myosin Light Chains - metabolism p38 Mitogen-Activated Protein Kinases - metabolism Pancreas - metabolism Pancreas - pathology Pancreatitis - metabolism Pancreatitis - pathology Phenotype Phosphorylation Rats Rats, Wistar
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