Lp(a) lipoprotein and lipids in patients with rheumatoid arthritis : serum levels and relationship to inflammation
Changes in lipid profiles, Lp(a) lipoprotein, and acute phase reactants are associated with early atherosclerosis in rheumatoid arthritis (RA). The associations of Lp(a) levels with atherosclerotic disorders, diabetes, RA, and renal diseases suggest that Lp(a) might be involved in autoimmune reactio...
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| Veröffentlicht in: | Rheumatology international 2005-05, Vol.25 (4), p.241-245 |
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| creator | DURSUNOGLU, Dursun EVRENGÜL, Harun POLAT, Bulent TANRIVERDI, Halil COBANKARA, Veli KAFTAN, Asuman KILIC, Mustafa |
| description | Changes in lipid profiles, Lp(a) lipoprotein, and acute phase reactants are associated with early atherosclerosis in rheumatoid arthritis (RA). The associations of Lp(a) levels with atherosclerotic disorders, diabetes, RA, and renal diseases suggest that Lp(a) might be involved in autoimmune reactions.
Eighty-seven women with RA diagnosed according to American Rheumatism Association criteria (mean age 45.4+/-9.4 years) were recruited and 50 healthy women (mean age 44+/-10.7 years) included as a control group. Serum Lp(a), total cholesterol (TC), triglyceride (TG), LDL cholesterol (LDL-C), HDL cholesterol (HDL-C), and C-reactive protein levels were analyzed.
In the RA and C groups, serum Lp(a) levels were 39.2+/-20.6 mg/dl and 14.8+/-9.7 mg/dl, respectively (P0.05), TG levels were 124.5+/-50.1 mg/dl and 94.6+/-24.9 mg/dl (P |
| doi_str_mv | 10.1007/s00296-004-0438-0 |
| format | Article |
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Eighty-seven women with RA diagnosed according to American Rheumatism Association criteria (mean age 45.4+/-9.4 years) were recruited and 50 healthy women (mean age 44+/-10.7 years) included as a control group. Serum Lp(a), total cholesterol (TC), triglyceride (TG), LDL cholesterol (LDL-C), HDL cholesterol (HDL-C), and C-reactive protein levels were analyzed.
In the RA and C groups, serum Lp(a) levels were 39.2+/-20.6 mg/dl and 14.8+/-9.7 mg/dl, respectively (P<0.001). The TC levels were 188.4+/-41.8 mg/dl and 185.3+/-19.3 mg/dl (P>0.05), TG levels were 124.5+/-50.1 mg/dl and 94.6+/-24.9 mg/dl (P<0.01), HDL-C levels were 40.0+/-7.4 mg/dl and 52.8+/-4.8 mg/dl (P<0.01), and LDL-C levels were 123.4+/-24.6 mg/dl and 113.3+/-21.1 mg/dl (P>0.05). While serum CRP levels showed a positive correlation with Lp(a), they correlated negatively with HDL-C levels (r=0.83 and P<0.0001, r=-0.49 and P<0.0001, respectively). It was meaningful that Lp(a) correlated negatively with serum HDL-C level (r=-0.36, P<0.001).
It is suggested that higher serum Lp(a), lower HDL-C, higher TG level, and a high ratio of TC/HDL-C might show high risk of atherosclerosis. Inflammation in RA may cause changes in HDL-C and Lp(a) metabolisms.]]></description><identifier>ISSN: 0172-8172</identifier><identifier>EISSN: 1437-160X</identifier><identifier>DOI: 10.1007/s00296-004-0438-0</identifier><identifier>PMID: 15290086</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>Acute-Phase Proteins - analysis ; Adult ; Arthritis, Rheumatoid - blood ; Arthritis, Rheumatoid - complications ; Arthritis, Rheumatoid - physiopathology ; Atherosclerosis ; Biological and medical sciences ; C-Reactive Protein - analysis ; Cardiovascular disease ; Cholesterol ; Cholesterol - blood ; Cholesterol, HDL - blood ; Cholesterol, LDL - blood ; Diet ; Diseases of the osteoarticular system ; Female ; Humans ; Hyperlipidemias - blood ; Inflammation - blood ; Inflammation - complications ; Inflammation - physiopathology ; Inflammatory joint diseases ; Lipoprotein(a) - blood ; Medical sciences ; Middle Aged ; Triglycerides - blood</subject><ispartof>Rheumatology international, 2005-05, Vol.25 (4), p.241-245</ispartof><rights>2005 INIST-CNRS</rights><rights>Springer-Verlag 2005</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-28613e548dae58ac62752bbfd412f555432f70cac437fb218eebb468c5a0ae3b3</citedby><cites>FETCH-LOGICAL-c356t-28613e548dae58ac62752bbfd412f555432f70cac437fb218eebb468c5a0ae3b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16787701$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15290086$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>DURSUNOGLU, Dursun</creatorcontrib><creatorcontrib>EVRENGÜL, Harun</creatorcontrib><creatorcontrib>POLAT, Bulent</creatorcontrib><creatorcontrib>TANRIVERDI, Halil</creatorcontrib><creatorcontrib>COBANKARA, Veli</creatorcontrib><creatorcontrib>KAFTAN, Asuman</creatorcontrib><creatorcontrib>KILIC, Mustafa</creatorcontrib><title>Lp(a) lipoprotein and lipids in patients with rheumatoid arthritis : serum levels and relationship to inflammation</title><title>Rheumatology international</title><addtitle>Rheumatol Int</addtitle><description><![CDATA[Changes in lipid profiles, Lp(a) lipoprotein, and acute phase reactants are associated with early atherosclerosis in rheumatoid arthritis (RA). The associations of Lp(a) levels with atherosclerotic disorders, diabetes, RA, and renal diseases suggest that Lp(a) might be involved in autoimmune reactions.
Eighty-seven women with RA diagnosed according to American Rheumatism Association criteria (mean age 45.4+/-9.4 years) were recruited and 50 healthy women (mean age 44+/-10.7 years) included as a control group. Serum Lp(a), total cholesterol (TC), triglyceride (TG), LDL cholesterol (LDL-C), HDL cholesterol (HDL-C), and C-reactive protein levels were analyzed.
In the RA and C groups, serum Lp(a) levels were 39.2+/-20.6 mg/dl and 14.8+/-9.7 mg/dl, respectively (P<0.001). The TC levels were 188.4+/-41.8 mg/dl and 185.3+/-19.3 mg/dl (P>0.05), TG levels were 124.5+/-50.1 mg/dl and 94.6+/-24.9 mg/dl (P<0.01), HDL-C levels were 40.0+/-7.4 mg/dl and 52.8+/-4.8 mg/dl (P<0.01), and LDL-C levels were 123.4+/-24.6 mg/dl and 113.3+/-21.1 mg/dl (P>0.05). While serum CRP levels showed a positive correlation with Lp(a), they correlated negatively with HDL-C levels (r=0.83 and P<0.0001, r=-0.49 and P<0.0001, respectively). It was meaningful that Lp(a) correlated negatively with serum HDL-C level (r=-0.36, P<0.001).
It is suggested that higher serum Lp(a), lower HDL-C, higher TG level, and a high ratio of TC/HDL-C might show high risk of atherosclerosis. Inflammation in RA may cause changes in HDL-C and Lp(a) metabolisms.]]></description><subject>Acute-Phase Proteins - analysis</subject><subject>Adult</subject><subject>Arthritis, Rheumatoid - blood</subject><subject>Arthritis, Rheumatoid - complications</subject><subject>Arthritis, Rheumatoid - physiopathology</subject><subject>Atherosclerosis</subject><subject>Biological and medical sciences</subject><subject>C-Reactive Protein - analysis</subject><subject>Cardiovascular disease</subject><subject>Cholesterol</subject><subject>Cholesterol - blood</subject><subject>Cholesterol, HDL - blood</subject><subject>Cholesterol, LDL - blood</subject><subject>Diet</subject><subject>Diseases of the osteoarticular system</subject><subject>Female</subject><subject>Humans</subject><subject>Hyperlipidemias - blood</subject><subject>Inflammation - blood</subject><subject>Inflammation - complications</subject><subject>Inflammation - physiopathology</subject><subject>Inflammatory joint diseases</subject><subject>Lipoprotein(a) - blood</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Triglycerides - blood</subject><issn>0172-8172</issn><issn>1437-160X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNpdkd1rHCEUxSU0JJu0f0BfihQakodprzo6bt5KyEdhoS8p9E0c5w5rcD6qTkr_-7jZhUBflCO_c7jXQ8hHBl8ZQPMtAfC1qgDqCmqhKzgiK1aLpmIKfr8jK2ANr3Q5TslZSk9QtFJwQk6Z5GsArVYkbuZLe0WDn6c5Thn9SO3Y7bTvEi1qttnjmBP96_OWxi0ug82T76iNeRt99ole04RxGWjAZwzp1R8xFN80pq2faZ5KUB_sMLy-vSfHvQ0JPxzuc_Lr7vbx5qHa_Lz_cfN9UzkhVa64VkygrHVnUWrrFG8kb9u-qxnvpZS14H0DzrqycN9yphHbtlbaSQsWRSvOycU-tyz2Z8GUzeCTwxDsiNOSjGo0hzXIAn7-D3yaljiW2YzWNRNCcCgQ20MuTilF7M0c_WDjP8PA7Now-zZMacPs2jA7z6dD8NIO2L05Dt9fgC8HwCZnQx_t6Hx648qITQNMvADQDpNY</recordid><startdate>20050501</startdate><enddate>20050501</enddate><creator>DURSUNOGLU, Dursun</creator><creator>EVRENGÜL, Harun</creator><creator>POLAT, Bulent</creator><creator>TANRIVERDI, Halil</creator><creator>COBANKARA, Veli</creator><creator>KAFTAN, Asuman</creator><creator>KILIC, Mustafa</creator><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>20050501</creationdate><title>Lp(a) lipoprotein and lipids in patients with rheumatoid arthritis : serum levels and relationship to inflammation</title><author>DURSUNOGLU, Dursun ; EVRENGÜL, Harun ; POLAT, Bulent ; TANRIVERDI, Halil ; COBANKARA, Veli ; KAFTAN, Asuman ; KILIC, Mustafa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-28613e548dae58ac62752bbfd412f555432f70cac437fb218eebb468c5a0ae3b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Acute-Phase Proteins - analysis</topic><topic>Adult</topic><topic>Arthritis, Rheumatoid - blood</topic><topic>Arthritis, Rheumatoid - complications</topic><topic>Arthritis, Rheumatoid - physiopathology</topic><topic>Atherosclerosis</topic><topic>Biological and medical sciences</topic><topic>C-Reactive Protein - analysis</topic><topic>Cardiovascular disease</topic><topic>Cholesterol</topic><topic>Cholesterol - blood</topic><topic>Cholesterol, HDL - blood</topic><topic>Cholesterol, LDL - blood</topic><topic>Diet</topic><topic>Diseases of the osteoarticular system</topic><topic>Female</topic><topic>Humans</topic><topic>Hyperlipidemias - blood</topic><topic>Inflammation - blood</topic><topic>Inflammation - complications</topic><topic>Inflammation - physiopathology</topic><topic>Inflammatory joint diseases</topic><topic>Lipoprotein(a) - blood</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Triglycerides - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>DURSUNOGLU, Dursun</creatorcontrib><creatorcontrib>EVRENGÜL, Harun</creatorcontrib><creatorcontrib>POLAT, Bulent</creatorcontrib><creatorcontrib>TANRIVERDI, Halil</creatorcontrib><creatorcontrib>COBANKARA, Veli</creatorcontrib><creatorcontrib>KAFTAN, Asuman</creatorcontrib><creatorcontrib>KILIC, Mustafa</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Rheumatology international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>DURSUNOGLU, Dursun</au><au>EVRENGÜL, Harun</au><au>POLAT, Bulent</au><au>TANRIVERDI, Halil</au><au>COBANKARA, Veli</au><au>KAFTAN, Asuman</au><au>KILIC, Mustafa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lp(a) lipoprotein and lipids in patients with rheumatoid arthritis : serum levels and relationship to inflammation</atitle><jtitle>Rheumatology international</jtitle><addtitle>Rheumatol Int</addtitle><date>2005-05-01</date><risdate>2005</risdate><volume>25</volume><issue>4</issue><spage>241</spage><epage>245</epage><pages>241-245</pages><issn>0172-8172</issn><eissn>1437-160X</eissn><abstract><![CDATA[Changes in lipid profiles, Lp(a) lipoprotein, and acute phase reactants are associated with early atherosclerosis in rheumatoid arthritis (RA). The associations of Lp(a) levels with atherosclerotic disorders, diabetes, RA, and renal diseases suggest that Lp(a) might be involved in autoimmune reactions.
Eighty-seven women with RA diagnosed according to American Rheumatism Association criteria (mean age 45.4+/-9.4 years) were recruited and 50 healthy women (mean age 44+/-10.7 years) included as a control group. Serum Lp(a), total cholesterol (TC), triglyceride (TG), LDL cholesterol (LDL-C), HDL cholesterol (HDL-C), and C-reactive protein levels were analyzed.
In the RA and C groups, serum Lp(a) levels were 39.2+/-20.6 mg/dl and 14.8+/-9.7 mg/dl, respectively (P<0.001). The TC levels were 188.4+/-41.8 mg/dl and 185.3+/-19.3 mg/dl (P>0.05), TG levels were 124.5+/-50.1 mg/dl and 94.6+/-24.9 mg/dl (P<0.01), HDL-C levels were 40.0+/-7.4 mg/dl and 52.8+/-4.8 mg/dl (P<0.01), and LDL-C levels were 123.4+/-24.6 mg/dl and 113.3+/-21.1 mg/dl (P>0.05). While serum CRP levels showed a positive correlation with Lp(a), they correlated negatively with HDL-C levels (r=0.83 and P<0.0001, r=-0.49 and P<0.0001, respectively). It was meaningful that Lp(a) correlated negatively with serum HDL-C level (r=-0.36, P<0.001).
It is suggested that higher serum Lp(a), lower HDL-C, higher TG level, and a high ratio of TC/HDL-C might show high risk of atherosclerosis. Inflammation in RA may cause changes in HDL-C and Lp(a) metabolisms.]]></abstract><cop>Berlin</cop><pub>Springer</pub><pmid>15290086</pmid><doi>10.1007/s00296-004-0438-0</doi><tpages>5</tpages></addata></record> |
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| subjects | Acute-Phase Proteins - analysis Adult Arthritis, Rheumatoid - blood Arthritis, Rheumatoid - complications Arthritis, Rheumatoid - physiopathology Atherosclerosis Biological and medical sciences C-Reactive Protein - analysis Cardiovascular disease Cholesterol Cholesterol - blood Cholesterol, HDL - blood Cholesterol, LDL - blood Diet Diseases of the osteoarticular system Female Humans Hyperlipidemias - blood Inflammation - blood Inflammation - complications Inflammation - physiopathology Inflammatory joint diseases Lipoprotein(a) - blood Medical sciences Middle Aged Triglycerides - blood |
| title | Lp(a) lipoprotein and lipids in patients with rheumatoid arthritis : serum levels and relationship to inflammation |
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