Pyruvate but not lactate prevents NADH-induced myoglobin oxidation

In this work, we investigated the influence of NADH on the redox state of myoglobin and the roles of pyruvate and lactate in this process. NADH increased the autoxidation rate of myoglobin. Both a drop in pH and partial deoxygenation markedly stimulated the autoxidation process and the influence of...

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Veröffentlicht in:	Free radical biology & medicine 2005-06, Vol.38 (11), p.1484-1490
Hauptverfasser:	Olek, Robert A., Antosiewicz, Jedrzej, Popinigis, Jerzy, Gabbianelli, Rosita, Fedeli, Donatella, Falcioni, Giancarlo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidants - metabolism Antioxidants - pharmacology Catalase Catalase - metabolism Chemiluminescence Dose-Response Relationship, Drug Free radicals Free Radicals - metabolism Horses Hydrogen Peroxide - pharmacology Hydrogen-Ion Concentration Kinetics l-lactate Lactates - metabolism Lactic Acid - chemistry Lactic Acid - metabolism Luminol Myocardium - metabolism Myoglobin Myoglobin - chemistry Myoglobin - metabolism NAD - chemistry NAD - metabolism NADH Oxidation-Reduction Oxygen - metabolism Pyruvate Pyruvic Acid - chemistry Pyruvic Acid - metabolism Reperfusion Injury ROS Time Factors
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