Defining and maintaining a high quality screening collection: the GSK experience

Understanding the quality of a screening collection is the first step to improving it and, as a result, the quality of the screening process. Understanding the quality of a screening collection is the first step to improving it and, as a result, the quality of the screening process. This article out...

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Veröffentlicht in:Drug discovery today 2006-03, Vol.11 (5-6), p.267-272
Hauptverfasser: Lane, Stephen J., Eggleston, Drake S., Brinded, Keith A., Hollerton, John C., Taylor, Nicholas L., Readshaw, Simon A.
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container_end_page 272
container_issue 5-6
container_start_page 267
container_title Drug discovery today
container_volume 11
creator Lane, Stephen J.
Eggleston, Drake S.
Brinded, Keith A.
Hollerton, John C.
Taylor, Nicholas L.
Readshaw, Simon A.
description Understanding the quality of a screening collection is the first step to improving it and, as a result, the quality of the screening process. Understanding the quality of a screening collection is the first step to improving it and, as a result, the quality of the screening process. This article outlines how this issue was approached at GlaxoSmithKline and some of the hurdles that needed to be overcome to achieve success. The article focuses specifically on the necessary software and hardware infrastructure needed, and at some of the extra benefits of such a project in terms of data mining and data modelling.
doi_str_mv 10.1016/S1359-6446(05)03730-X
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subjects array
Biological and medical sciences
Chromatography, High Pressure Liquid
Combinatorial Chemistry Techniques - methods
Combinatorial Chemistry Techniques - organization & administration
Computers
data mining
Drug Industry - methods
General pharmacology
GlaxoSmithKline
HTS
Information Storage and Retrieval - methods
Magnetic Resonance Spectroscopy
Mass Spectrometry
Medical sciences
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
platelookup
Quality Control
Software
title Defining and maintaining a high quality screening collection: the GSK experience
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