Clinical significance of the physicochemical properties of LDL in type 2 diabetes
Atherosclerosis is the leading cause of death in type 2 diabetes. LDL cholesterol and atherosclerosis are related, both in healthy people and those with diabetes; however, people with diabetes are more prone to atheroma, even though their LDL cholesterol levels are similar to those in their non-diab...
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| Veröffentlicht in: | Diabetologia 2005-05, Vol.48 (5), p.808-816 |
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| container_title | Diabetologia |
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| creator | SCHEFFER, P. G TEERLINK, T HEINE, R. J |
| description | Atherosclerosis is the leading cause of death in type 2 diabetes. LDL cholesterol and atherosclerosis are related, both in healthy people and those with diabetes; however, people with diabetes are more prone to atheroma, even though their LDL cholesterol levels are similar to those in their non-diabetic peers. This is because LDL particles are modified in the presence of diabetes to become more atherogenic. These modifications include glycation in response to high plasma glucose levels; oxidative reactions mediated by increased oxidative stress; and transfer of cholesterol ester, which makes the particles smaller and denser. The latter modification is strongly associated with hypertriglyceridaemia. Oxidatively and non-oxidatively modified LDL is involved in plaque formation, and may thus contribute to the accelerated atherosclerosis. This review discusses the techniques currently used to determine the physicochemical properties of LDL, and examines the evidence that modification of these properties plays a role in the accelerated atherosclerosis associated with type 2 diabetes. |
| doi_str_mv | 10.1007/s00125-005-1736-0 |
| format | Article |
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This review discusses the techniques currently used to determine the physicochemical properties of LDL, and examines the evidence that modification of these properties plays a role in the accelerated atherosclerosis associated with type 2 diabetes.</description><identifier>ISSN: 0012-186X</identifier><identifier>EISSN: 1432-0428</identifier><identifier>DOI: 10.1007/s00125-005-1736-0</identifier><identifier>PMID: 15830178</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>Arteriosclerosis - epidemiology ; Arteriosclerosis - mortality ; Atherosclerosis (general aspects, experimental research) ; Biological and medical sciences ; Blood and lymphatic vessels ; Cardiology. Vascular system ; Cardiovascular disease ; Cholesterol, LDL - blood ; Diabetes Mellitus, Type 2 - blood ; Diabetes Mellitus, Type 2 - physiopathology ; Diabetes. Impaired glucose tolerance ; Diabetic Angiopathies - epidemiology ; Diabetic Angiopathies - mortality ; Endocrine pancreas. 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G</creatorcontrib><creatorcontrib>TEERLINK, T</creatorcontrib><creatorcontrib>HEINE, R. J</creatorcontrib><title>Clinical significance of the physicochemical properties of LDL in type 2 diabetes</title><title>Diabetologia</title><addtitle>Diabetologia</addtitle><description>Atherosclerosis is the leading cause of death in type 2 diabetes. LDL cholesterol and atherosclerosis are related, both in healthy people and those with diabetes; however, people with diabetes are more prone to atheroma, even though their LDL cholesterol levels are similar to those in their non-diabetic peers. This is because LDL particles are modified in the presence of diabetes to become more atherogenic. These modifications include glycation in response to high plasma glucose levels; oxidative reactions mediated by increased oxidative stress; and transfer of cholesterol ester, which makes the particles smaller and denser. The latter modification is strongly associated with hypertriglyceridaemia. Oxidatively and non-oxidatively modified LDL is involved in plaque formation, and may thus contribute to the accelerated atherosclerosis. This review discusses the techniques currently used to determine the physicochemical properties of LDL, and examines the evidence that modification of these properties plays a role in the accelerated atherosclerosis associated with type 2 diabetes.</description><subject>Arteriosclerosis - epidemiology</subject><subject>Arteriosclerosis - mortality</subject><subject>Atherosclerosis (general aspects, experimental research)</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Cardiology. Vascular system</subject><subject>Cardiovascular disease</subject><subject>Cholesterol, LDL - blood</subject><subject>Diabetes Mellitus, Type 2 - blood</subject><subject>Diabetes Mellitus, Type 2 - physiopathology</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Diabetic Angiopathies - epidemiology</subject><subject>Diabetic Angiopathies - mortality</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>High density lipoprotein</subject><subject>Humans</subject><subject>Insulin resistance</subject><subject>Lipids</subject><subject>Lipids - blood</subject><subject>Lipoproteins, LDL - blood</subject><subject>Medical sciences</subject><subject>Models, Biological</subject><subject>Mortality</subject><subject>Oxidative Stress</subject><subject>Triglycerides - blood</subject><issn>0012-186X</issn><issn>1432-0428</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNpd0E1Lw0AQgOFFFFurP8CLBEFv0ZnsZ45SP6EggoK3JUln7ZY0idn00H_v1hYET7uwzwzLy9g5wg0C6NsAgJlMAWSKmqsUDtgYBc9SEJk5ZOPtc4pGfY7YSQhLAOBSqGM2Qmk4oDZj9jatfeOrok6C_2q8i9emoqR1ybCgpFtsgq_aakGrX9P1bUf94Clsxex-lvgmGTYdJVky90VJA4VTduSKOtDZ_pywj8eH9-lzOnt9epnezdJKKDmkTiDles4zEmAwl7krUMtcCyxLXercuVIB5yQlFgJVKbjCKiKXo9CR8Am73u2Nn_peUxjsyoeK6rpoqF0Hq7RBE9dFePkPLtt138S_2Qy5EcpwFRHuUNW3IfTkbNf7VdFvLILdxra72DbGttvYFuLMxX7xulzR_G9iXzeCqz0oQszn-tjWhz-nDCBmnP8Aq7GFMg</recordid><startdate>20050501</startdate><enddate>20050501</enddate><creator>SCHEFFER, P. 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| subjects | Arteriosclerosis - epidemiology Arteriosclerosis - mortality Atherosclerosis (general aspects, experimental research) Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Cardiovascular disease Cholesterol, LDL - blood Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - physiopathology Diabetes. Impaired glucose tolerance Diabetic Angiopathies - epidemiology Diabetic Angiopathies - mortality Endocrine pancreas. Apud cells (diseases) Endocrinopathies High density lipoprotein Humans Insulin resistance Lipids Lipids - blood Lipoproteins, LDL - blood Medical sciences Models, Biological Mortality Oxidative Stress Triglycerides - blood |
| title | Clinical significance of the physicochemical properties of LDL in type 2 diabetes |
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