MeCP2-Dependent Transcriptional Repression Regulates Excitatory Neurotransmission

Mutations in the transcriptional repressor, methyl-CpG binding protein 2 (MeCP2), result in a neurodevelopmental disorder called Rett Syndrome (RTT) [1–5]. Based on the neurological phenotypes observed in Rett patients, we examined the potential role of MeCP2 in synaptic function. We compared elemen...

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Veröffentlicht in:	Current biology 2006-04, Vol.16 (7), p.710-716
Hauptverfasser:	Nelson, Erika D., Kavalali, Ege T., Monteggia, Lisa M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cells, Cultured DNA Evoked Potentials - physiology Gene Silencing Hippocampus - cytology Integrases - metabolism Lentivirus Lentivirus - metabolism Methyl-CpG-Binding Protein 2 - genetics Methyl-CpG-Binding Protein 2 - physiology Mice Mutation Neurons - cytology Neurons - physiology Neurons - virology Repressor Proteins - genetics Repressor Proteins - physiology Synaptic Transmission - genetics Transcription, Genetic Viral Proteins - metabolism
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