Natural History of Adult-Onset Laryngeal Papillomatosis following Multiple Cidofovir Injections
Objectives: A prospective study was performed to assess the intermediate and long-term efficacy of intralesional cidofovir therapy associated with surgical excision in laryngeal papillomatosis in adults. Methods: Endoscopy with intralesional injection of cidofovir 5 mg/mL was performed 3 times at 4-...
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| Veröffentlicht in: | Annals of otology, rhinology & laryngology rhinology & laryngology, 2006-03, Vol.115 (3), p.175-181 |
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| container_title | Annals of otology, rhinology & laryngology |
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| creator | Naiman, Ana Nusa Abedipour, Darius Ayari, Sonia Fresnel, Elizabeth Coulombeau, Bruno Bour, Jean-Baptiste Froehlich, Patrick |
| description | Objectives:
A prospective study was performed to assess the intermediate and long-term efficacy of intralesional cidofovir therapy associated with surgical excision in laryngeal papillomatosis in adults.
Methods:
Endoscopy with intralesional injection of cidofovir 5 mg/mL was performed 3 times at 4-week intervals. The concentration was later increased to 7.5 mg/mL and the interval between injections shortened to 2 weeks. Further treatment was performed at 3 or 6 months, depending on the evolution of the papillomas. After complete remission, the treatment was stopped and the patients were reviewed every 6 months.
Results:
Nineteen patients completed the protocol, with a mean of 4.5 injections each. Complete remission was obtained in 17 cases (89%) after a mean of 3.8 procedures. Remission was stable after a mean follow-up of 24 months (range, 8 to 57 months). With higher cidofovir concentrations at shorter intervals, patients needed fewer injections to achieve remission (mean, 2.1 versus 4.7 injections).
Conclusions:
The effectiveness of intralesional cidofovir therapy in adult-onset recurrent respiratory papillomatosis was impressive. Once obtained, complete remission was stable on intermediate or long-term follow-up. The concentration and the interval between injections seemed to influence the number of injections necessary to achieve remission. |
| doi_str_mv | 10.1177/000348940611500303 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_67818634</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.1177_000348940611500303</sage_id><sourcerecordid>1012913221</sourcerecordid><originalsourceid>FETCH-LOGICAL-c464t-3210b3aa0294c8205a5fac7e1d2610c88a9e30151e20cf811d08aa22703443243</originalsourceid><addsrcrecordid>eNp90EtLAzEQB_AgitbHF_Agi6C3tZk89nGU4guq9aDgbRmz2ZKSbmqyq_jtzdJCQcFTZuA3k-FPyCnQK4A8H1NKuShKQTMAGWvKd8gISsFTmbO3XTIaQDqIA3IYwiK2QlK2Tw4giyKjckSqJ-x6jza5N6Fz_jtxTXJd97ZLZ23QXTJF_93OdQTPuDLWuiV2LpiQNC42X6adJ49Rm5XVycTUrnGfxicP7UKrzrg2HJO9Bm3QJ5v3iLze3rxM7tPp7O5hcj1NlchEl3IG9J0jUlYKVTAqUTaocg01y4CqosBScwoSNKOqKQBqWiAylscEBGeCH5HL9d6Vdx-9Dl21NEFpa7HVrg9VlhdQZHyA57_gwvW-jbdVDPJyyHJAbI2UdyF43VQrb5YxigpoNWRf_c0-Dp1tNvfvS11vRzZhR3CxARgU2sZjq0zYulyWMmMQ3XjtAs719rx_vv4BkBaX9w</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>217906114</pqid></control><display><type>article</type><title>Natural History of Adult-Onset Laryngeal Papillomatosis following Multiple Cidofovir Injections</title><source>SAGE Complete A-Z List</source><source>MEDLINE</source><creator>Naiman, Ana Nusa ; Abedipour, Darius ; Ayari, Sonia ; Fresnel, Elizabeth ; Coulombeau, Bruno ; Bour, Jean-Baptiste ; Froehlich, Patrick</creator><creatorcontrib>Naiman, Ana Nusa ; Abedipour, Darius ; Ayari, Sonia ; Fresnel, Elizabeth ; Coulombeau, Bruno ; Bour, Jean-Baptiste ; Froehlich, Patrick</creatorcontrib><description>Objectives:
A prospective study was performed to assess the intermediate and long-term efficacy of intralesional cidofovir therapy associated with surgical excision in laryngeal papillomatosis in adults.
Methods:
Endoscopy with intralesional injection of cidofovir 5 mg/mL was performed 3 times at 4-week intervals. The concentration was later increased to 7.5 mg/mL and the interval between injections shortened to 2 weeks. Further treatment was performed at 3 or 6 months, depending on the evolution of the papillomas. After complete remission, the treatment was stopped and the patients were reviewed every 6 months.
Results:
Nineteen patients completed the protocol, with a mean of 4.5 injections each. Complete remission was obtained in 17 cases (89%) after a mean of 3.8 procedures. Remission was stable after a mean follow-up of 24 months (range, 8 to 57 months). With higher cidofovir concentrations at shorter intervals, patients needed fewer injections to achieve remission (mean, 2.1 versus 4.7 injections).
Conclusions:
The effectiveness of intralesional cidofovir therapy in adult-onset recurrent respiratory papillomatosis was impressive. Once obtained, complete remission was stable on intermediate or long-term follow-up. The concentration and the interval between injections seemed to influence the number of injections necessary to achieve remission.</description><identifier>ISSN: 0003-4894</identifier><identifier>EISSN: 1943-572X</identifier><identifier>DOI: 10.1177/000348940611500303</identifier><identifier>PMID: 16572605</identifier><identifier>CODEN: AORHA2</identifier><language>eng</language><publisher>Los Angeles, CA: SAGE Publications</publisher><subject>Adult ; Antiviral Agents - administration & dosage ; Biological and medical sciences ; Biopsy ; Cytosine - administration & dosage ; Cytosine - analogs & derivatives ; DNA, Viral - analysis ; Female ; Follow-Up Studies ; Human papillomavirus 6 - genetics ; Humans ; Injections, Intralesional ; Laryngeal Neoplasms - drug therapy ; Laryngeal Neoplasms - surgery ; Laryngeal Neoplasms - virology ; Laryngoscopy ; Male ; Medical sciences ; Middle Aged ; Organophosphonates - administration & dosage ; Otorhinolaryngology. Stomatology ; Papilloma - drug therapy ; Papilloma - surgery ; Papilloma - virology ; Papillomavirus Infections - drug therapy ; Papillomavirus Infections - pathology ; Papillomavirus Infections - virology ; Prospective Studies ; Time Factors ; Treatment Outcome ; Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</subject><ispartof>Annals of otology, rhinology & laryngology, 2006-03, Vol.115 (3), p.175-181</ispartof><rights>2006 SAGE Publications</rights><rights>2006 INIST-CNRS</rights><rights>Copyright Annals Publishing Company Mar 2006</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c464t-3210b3aa0294c8205a5fac7e1d2610c88a9e30151e20cf811d08aa22703443243</citedby><cites>FETCH-LOGICAL-c464t-3210b3aa0294c8205a5fac7e1d2610c88a9e30151e20cf811d08aa22703443243</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/000348940611500303$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/000348940611500303$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,776,780,21798,27901,27902,43597,43598</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17595621$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16572605$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Naiman, Ana Nusa</creatorcontrib><creatorcontrib>Abedipour, Darius</creatorcontrib><creatorcontrib>Ayari, Sonia</creatorcontrib><creatorcontrib>Fresnel, Elizabeth</creatorcontrib><creatorcontrib>Coulombeau, Bruno</creatorcontrib><creatorcontrib>Bour, Jean-Baptiste</creatorcontrib><creatorcontrib>Froehlich, Patrick</creatorcontrib><title>Natural History of Adult-Onset Laryngeal Papillomatosis following Multiple Cidofovir Injections</title><title>Annals of otology, rhinology & laryngology</title><addtitle>Ann Otol Rhinol Laryngol</addtitle><description>Objectives:
A prospective study was performed to assess the intermediate and long-term efficacy of intralesional cidofovir therapy associated with surgical excision in laryngeal papillomatosis in adults.
Methods:
Endoscopy with intralesional injection of cidofovir 5 mg/mL was performed 3 times at 4-week intervals. The concentration was later increased to 7.5 mg/mL and the interval between injections shortened to 2 weeks. Further treatment was performed at 3 or 6 months, depending on the evolution of the papillomas. After complete remission, the treatment was stopped and the patients were reviewed every 6 months.
Results:
Nineteen patients completed the protocol, with a mean of 4.5 injections each. Complete remission was obtained in 17 cases (89%) after a mean of 3.8 procedures. Remission was stable after a mean follow-up of 24 months (range, 8 to 57 months). With higher cidofovir concentrations at shorter intervals, patients needed fewer injections to achieve remission (mean, 2.1 versus 4.7 injections).
Conclusions:
The effectiveness of intralesional cidofovir therapy in adult-onset recurrent respiratory papillomatosis was impressive. Once obtained, complete remission was stable on intermediate or long-term follow-up. The concentration and the interval between injections seemed to influence the number of injections necessary to achieve remission.</description><subject>Adult</subject><subject>Antiviral Agents - administration & dosage</subject><subject>Biological and medical sciences</subject><subject>Biopsy</subject><subject>Cytosine - administration & dosage</subject><subject>Cytosine - analogs & derivatives</subject><subject>DNA, Viral - analysis</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Human papillomavirus 6 - genetics</subject><subject>Humans</subject><subject>Injections, Intralesional</subject><subject>Laryngeal Neoplasms - drug therapy</subject><subject>Laryngeal Neoplasms - surgery</subject><subject>Laryngeal Neoplasms - virology</subject><subject>Laryngoscopy</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Organophosphonates - administration & dosage</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>Papilloma - drug therapy</subject><subject>Papilloma - surgery</subject><subject>Papilloma - virology</subject><subject>Papillomavirus Infections - drug therapy</subject><subject>Papillomavirus Infections - pathology</subject><subject>Papillomavirus Infections - virology</subject><subject>Prospective Studies</subject><subject>Time Factors</subject><subject>Treatment Outcome</subject><subject>Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</subject><issn>0003-4894</issn><issn>1943-572X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp90EtLAzEQB_AgitbHF_Agi6C3tZk89nGU4guq9aDgbRmz2ZKSbmqyq_jtzdJCQcFTZuA3k-FPyCnQK4A8H1NKuShKQTMAGWvKd8gISsFTmbO3XTIaQDqIA3IYwiK2QlK2Tw4giyKjckSqJ-x6jza5N6Fz_jtxTXJd97ZLZ23QXTJF_93OdQTPuDLWuiV2LpiQNC42X6adJ49Rm5XVycTUrnGfxicP7UKrzrg2HJO9Bm3QJ5v3iLze3rxM7tPp7O5hcj1NlchEl3IG9J0jUlYKVTAqUTaocg01y4CqosBScwoSNKOqKQBqWiAylscEBGeCH5HL9d6Vdx-9Dl21NEFpa7HVrg9VlhdQZHyA57_gwvW-jbdVDPJyyHJAbI2UdyF43VQrb5YxigpoNWRf_c0-Dp1tNvfvS11vRzZhR3CxARgU2sZjq0zYulyWMmMQ3XjtAs719rx_vv4BkBaX9w</recordid><startdate>20060301</startdate><enddate>20060301</enddate><creator>Naiman, Ana Nusa</creator><creator>Abedipour, Darius</creator><creator>Ayari, Sonia</creator><creator>Fresnel, Elizabeth</creator><creator>Coulombeau, Bruno</creator><creator>Bour, Jean-Baptiste</creator><creator>Froehlich, Patrick</creator><general>SAGE Publications</general><general>Annals Publishing Compagny</general><general>SAGE PUBLICATIONS, INC</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>S0X</scope><scope>7X8</scope><scope>8BM</scope></search><sort><creationdate>20060301</creationdate><title>Natural History of Adult-Onset Laryngeal Papillomatosis following Multiple Cidofovir Injections</title><author>Naiman, Ana Nusa ; Abedipour, Darius ; Ayari, Sonia ; Fresnel, Elizabeth ; Coulombeau, Bruno ; Bour, Jean-Baptiste ; Froehlich, Patrick</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c464t-3210b3aa0294c8205a5fac7e1d2610c88a9e30151e20cf811d08aa22703443243</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adult</topic><topic>Antiviral Agents - administration & dosage</topic><topic>Biological and medical sciences</topic><topic>Biopsy</topic><topic>Cytosine - administration & dosage</topic><topic>Cytosine - analogs & derivatives</topic><topic>DNA, Viral - analysis</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Human papillomavirus 6 - genetics</topic><topic>Humans</topic><topic>Injections, Intralesional</topic><topic>Laryngeal Neoplasms - drug therapy</topic><topic>Laryngeal Neoplasms - surgery</topic><topic>Laryngeal Neoplasms - virology</topic><topic>Laryngoscopy</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Organophosphonates - administration & dosage</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>Papilloma - drug therapy</topic><topic>Papilloma - surgery</topic><topic>Papilloma - virology</topic><topic>Papillomavirus Infections - drug therapy</topic><topic>Papillomavirus Infections - pathology</topic><topic>Papillomavirus Infections - virology</topic><topic>Prospective Studies</topic><topic>Time Factors</topic><topic>Treatment Outcome</topic><topic>Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Naiman, Ana Nusa</creatorcontrib><creatorcontrib>Abedipour, Darius</creatorcontrib><creatorcontrib>Ayari, Sonia</creatorcontrib><creatorcontrib>Fresnel, Elizabeth</creatorcontrib><creatorcontrib>Coulombeau, Bruno</creatorcontrib><creatorcontrib>Bour, Jean-Baptiste</creatorcontrib><creatorcontrib>Froehlich, Patrick</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>SIRS Editorial</collection><collection>MEDLINE - Academic</collection><collection>ComDisDome</collection><jtitle>Annals of otology, rhinology & laryngology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Naiman, Ana Nusa</au><au>Abedipour, Darius</au><au>Ayari, Sonia</au><au>Fresnel, Elizabeth</au><au>Coulombeau, Bruno</au><au>Bour, Jean-Baptiste</au><au>Froehlich, Patrick</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Natural History of Adult-Onset Laryngeal Papillomatosis following Multiple Cidofovir Injections</atitle><jtitle>Annals of otology, rhinology & laryngology</jtitle><addtitle>Ann Otol Rhinol Laryngol</addtitle><date>2006-03-01</date><risdate>2006</risdate><volume>115</volume><issue>3</issue><spage>175</spage><epage>181</epage><pages>175-181</pages><issn>0003-4894</issn><eissn>1943-572X</eissn><coden>AORHA2</coden><abstract>Objectives:
A prospective study was performed to assess the intermediate and long-term efficacy of intralesional cidofovir therapy associated with surgical excision in laryngeal papillomatosis in adults.
Methods:
Endoscopy with intralesional injection of cidofovir 5 mg/mL was performed 3 times at 4-week intervals. The concentration was later increased to 7.5 mg/mL and the interval between injections shortened to 2 weeks. Further treatment was performed at 3 or 6 months, depending on the evolution of the papillomas. After complete remission, the treatment was stopped and the patients were reviewed every 6 months.
Results:
Nineteen patients completed the protocol, with a mean of 4.5 injections each. Complete remission was obtained in 17 cases (89%) after a mean of 3.8 procedures. Remission was stable after a mean follow-up of 24 months (range, 8 to 57 months). With higher cidofovir concentrations at shorter intervals, patients needed fewer injections to achieve remission (mean, 2.1 versus 4.7 injections).
Conclusions:
The effectiveness of intralesional cidofovir therapy in adult-onset recurrent respiratory papillomatosis was impressive. Once obtained, complete remission was stable on intermediate or long-term follow-up. The concentration and the interval between injections seemed to influence the number of injections necessary to achieve remission.</abstract><cop>Los Angeles, CA</cop><pub>SAGE Publications</pub><pmid>16572605</pmid><doi>10.1177/000348940611500303</doi><tpages>7</tpages></addata></record> |
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| ispartof | Annals of otology, rhinology & laryngology, 2006-03, Vol.115 (3), p.175-181 |
| issn | 0003-4894 1943-572X |
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| source | SAGE Complete A-Z List; MEDLINE |
| subjects | Adult Antiviral Agents - administration & dosage Biological and medical sciences Biopsy Cytosine - administration & dosage Cytosine - analogs & derivatives DNA, Viral - analysis Female Follow-Up Studies Human papillomavirus 6 - genetics Humans Injections, Intralesional Laryngeal Neoplasms - drug therapy Laryngeal Neoplasms - surgery Laryngeal Neoplasms - virology Laryngoscopy Male Medical sciences Middle Aged Organophosphonates - administration & dosage Otorhinolaryngology. Stomatology Papilloma - drug therapy Papilloma - surgery Papilloma - virology Papillomavirus Infections - drug therapy Papillomavirus Infections - pathology Papillomavirus Infections - virology Prospective Studies Time Factors Treatment Outcome Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology |
| title | Natural History of Adult-Onset Laryngeal Papillomatosis following Multiple Cidofovir Injections |
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