Regulatory properties of adenylate cyclases type 5 and 6: A progress report
Adenylate cyclases (AC) type 5 and 6 comprise the calcium-inhibited family of adenylate cyclase isoforms. Here we review recent discoveries in the regulation of AC5 and AC6 with a focus on posttranslational modifications including glycosylation, nitrosylation, and phosphorylation by the cyclic AMP-d...
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| Veröffentlicht in: | European journal of pharmacology 2006-03, Vol.535 (1), p.1-12 |
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| creator | Beazely, Michael A. Watts, Val J. |
| description | Adenylate cyclases (AC) type 5 and 6 comprise the calcium-inhibited family of adenylate cyclase isoforms. Here we review recent discoveries in the regulation of AC5 and AC6 with a focus on posttranslational modifications including glycosylation, nitrosylation, and phosphorylation by the cyclic AMP-dependent protein kinase (PKA), protein kinase C (PKC), and Raf1. We also describe novel signaling interactions such as Gα
q-mediated potentiation of AC6 activation. Novel regulators of AC5 and AC6, including small molecules and proteins that physically interact with AC5 and AC6 such as snapin, regulator of G protein signaling 2 (RGS2), protein associated with myc (PAM), and caveolin peptides are discussed. We also describe several recent studies that demonstrate the usefulness of transgenic or adenoviral overexpression of AC5 and AC6 in models for disease states such as cardiovascular hypertrophy. The discovery of novel regulatory mechanisms for AC5 and AC6 and their potential role in crucial physiological processes provide new avenues for research into therapeutic interventions targeting the cyclic AMP pathway. |
| doi_str_mv | 10.1016/j.ejphar.2006.01.054 |
| format | Article |
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q-mediated potentiation of AC6 activation. Novel regulators of AC5 and AC6, including small molecules and proteins that physically interact with AC5 and AC6 such as snapin, regulator of G protein signaling 2 (RGS2), protein associated with myc (PAM), and caveolin peptides are discussed. We also describe several recent studies that demonstrate the usefulness of transgenic or adenoviral overexpression of AC5 and AC6 in models for disease states such as cardiovascular hypertrophy. The discovery of novel regulatory mechanisms for AC5 and AC6 and their potential role in crucial physiological processes provide new avenues for research into therapeutic interventions targeting the cyclic AMP pathway.</description><identifier>ISSN: 0014-2999</identifier><identifier>EISSN: 1879-0712</identifier><identifier>DOI: 10.1016/j.ejphar.2006.01.054</identifier><identifier>PMID: 16527269</identifier><identifier>CODEN: EJPHAZ</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Adenylate cyclase ; Adenylyl Cyclases - genetics ; Adenylyl Cyclases - metabolism ; Amino Acid Sequence ; Animals ; Biological and medical sciences ; Calcium - metabolism ; Cyclic AMP ; G protein-coupled receptor ; Humans ; Isoenzymes - genetics ; Isoenzymes - metabolism ; Kinase ; Medical sciences ; Molecular Sequence Data ; Pharmacology. Drug treatments ; Protein Processing, Post-Translational - physiology ; Sequence Homology, Amino Acid ; Signal Transduction - physiology ; Signaling</subject><ispartof>European journal of pharmacology, 2006-03, Vol.535 (1), p.1-12</ispartof><rights>2006 Elsevier B.V.</rights><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c390t-c74b1a386e2e77384e63a79715de8ca5012821315d5c24a4415a3ed54bfed95a3</citedby><cites>FETCH-LOGICAL-c390t-c74b1a386e2e77384e63a79715de8ca5012821315d5c24a4415a3ed54bfed95a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ejphar.2006.01.054$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17630067$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16527269$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Beazely, Michael A.</creatorcontrib><creatorcontrib>Watts, Val J.</creatorcontrib><title>Regulatory properties of adenylate cyclases type 5 and 6: A progress report</title><title>European journal of pharmacology</title><addtitle>Eur J Pharmacol</addtitle><description>Adenylate cyclases (AC) type 5 and 6 comprise the calcium-inhibited family of adenylate cyclase isoforms. Here we review recent discoveries in the regulation of AC5 and AC6 with a focus on posttranslational modifications including glycosylation, nitrosylation, and phosphorylation by the cyclic AMP-dependent protein kinase (PKA), protein kinase C (PKC), and Raf1. We also describe novel signaling interactions such as Gα
q-mediated potentiation of AC6 activation. Novel regulators of AC5 and AC6, including small molecules and proteins that physically interact with AC5 and AC6 such as snapin, regulator of G protein signaling 2 (RGS2), protein associated with myc (PAM), and caveolin peptides are discussed. We also describe several recent studies that demonstrate the usefulness of transgenic or adenoviral overexpression of AC5 and AC6 in models for disease states such as cardiovascular hypertrophy. The discovery of novel regulatory mechanisms for AC5 and AC6 and their potential role in crucial physiological processes provide new avenues for research into therapeutic interventions targeting the cyclic AMP pathway.</description><subject>Adenylate cyclase</subject><subject>Adenylyl Cyclases - genetics</subject><subject>Adenylyl Cyclases - metabolism</subject><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Calcium - metabolism</subject><subject>Cyclic AMP</subject><subject>G protein-coupled receptor</subject><subject>Humans</subject><subject>Isoenzymes - genetics</subject><subject>Isoenzymes - metabolism</subject><subject>Kinase</subject><subject>Medical sciences</subject><subject>Molecular Sequence Data</subject><subject>Pharmacology. Drug treatments</subject><subject>Protein Processing, Post-Translational - physiology</subject><subject>Sequence Homology, Amino Acid</subject><subject>Signal Transduction - physiology</subject><subject>Signaling</subject><issn>0014-2999</issn><issn>1879-0712</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kFtLwzAYhoMobk7_gUhu9K41SXNovBDG8IQDQfQ6ZOnX2dG1NemE_nszOvDOq5ye9_3Cg9AlJSklVN5uUth0X9anjBCZEpoSwY_QlOZKJ0RRdoymhFCeMK31BJ2FsCGECM3EKZpQKZhiUk_R6zusd7XtWz_gzrcd-L6CgNsS2wKaIb4AdoOrbYi3_dABFtg2BZZ3eL4PrD2EgD10re_P0Ulp6wAXh3WGPh8fPhbPyfLt6WUxXyYu06RPnOIrarNcAgOlspyDzKzSiooCcmcFoSxnNItH4Ri3nFNhMygEX5VQ6LifoZuxN87_3kHozbYKDuraNtDugpEqp7FBRZCPoPNtCB5K0_lqa_1gKDF7iWZjRolmL9EQaqLEGLs69O9WWyj-QgdrEbg-ADY4W5feNq4Kf5ySWazbz78fOYg2firwJrgKGgdF5cH1pmir_3_yC_J4kMU</recordid><startdate>20060327</startdate><enddate>20060327</enddate><creator>Beazely, Michael A.</creator><creator>Watts, Val J.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20060327</creationdate><title>Regulatory properties of adenylate cyclases type 5 and 6: A progress report</title><author>Beazely, Michael A. ; Watts, Val J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c390t-c74b1a386e2e77384e63a79715de8ca5012821315d5c24a4415a3ed54bfed95a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adenylate cyclase</topic><topic>Adenylyl Cyclases - genetics</topic><topic>Adenylyl Cyclases - metabolism</topic><topic>Amino Acid Sequence</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Calcium - metabolism</topic><topic>Cyclic AMP</topic><topic>G protein-coupled receptor</topic><topic>Humans</topic><topic>Isoenzymes - genetics</topic><topic>Isoenzymes - metabolism</topic><topic>Kinase</topic><topic>Medical sciences</topic><topic>Molecular Sequence Data</topic><topic>Pharmacology. Drug treatments</topic><topic>Protein Processing, Post-Translational - physiology</topic><topic>Sequence Homology, Amino Acid</topic><topic>Signal Transduction - physiology</topic><topic>Signaling</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Beazely, Michael A.</creatorcontrib><creatorcontrib>Watts, Val J.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Beazely, Michael A.</au><au>Watts, Val J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Regulatory properties of adenylate cyclases type 5 and 6: A progress report</atitle><jtitle>European journal of pharmacology</jtitle><addtitle>Eur J Pharmacol</addtitle><date>2006-03-27</date><risdate>2006</risdate><volume>535</volume><issue>1</issue><spage>1</spage><epage>12</epage><pages>1-12</pages><issn>0014-2999</issn><eissn>1879-0712</eissn><coden>EJPHAZ</coden><abstract>Adenylate cyclases (AC) type 5 and 6 comprise the calcium-inhibited family of adenylate cyclase isoforms. Here we review recent discoveries in the regulation of AC5 and AC6 with a focus on posttranslational modifications including glycosylation, nitrosylation, and phosphorylation by the cyclic AMP-dependent protein kinase (PKA), protein kinase C (PKC), and Raf1. We also describe novel signaling interactions such as Gα
q-mediated potentiation of AC6 activation. Novel regulators of AC5 and AC6, including small molecules and proteins that physically interact with AC5 and AC6 such as snapin, regulator of G protein signaling 2 (RGS2), protein associated with myc (PAM), and caveolin peptides are discussed. We also describe several recent studies that demonstrate the usefulness of transgenic or adenoviral overexpression of AC5 and AC6 in models for disease states such as cardiovascular hypertrophy. The discovery of novel regulatory mechanisms for AC5 and AC6 and their potential role in crucial physiological processes provide new avenues for research into therapeutic interventions targeting the cyclic AMP pathway.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>16527269</pmid><doi>10.1016/j.ejphar.2006.01.054</doi><tpages>12</tpages></addata></record> |
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| subjects | Adenylate cyclase Adenylyl Cyclases - genetics Adenylyl Cyclases - metabolism Amino Acid Sequence Animals Biological and medical sciences Calcium - metabolism Cyclic AMP G protein-coupled receptor Humans Isoenzymes - genetics Isoenzymes - metabolism Kinase Medical sciences Molecular Sequence Data Pharmacology. Drug treatments Protein Processing, Post-Translational - physiology Sequence Homology, Amino Acid Signal Transduction - physiology Signaling |
| title | Regulatory properties of adenylate cyclases type 5 and 6: A progress report |
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