Is MELD score sufficient to predict not only death on waiting list, but also post‐transplant survival?
Summary Model for end‐stage liver disease (MELD) score has emerged as a useful tool in predicting mortality in patients awaiting liver transplantation. There is still, however, discussion as to whether further parameters could improve the sensitivity and specificity of the MELD score. From 1997 to 2...
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| Veröffentlicht in: | Transplant international 2006-04, Vol.19 (4), p.275-281 |
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| creator | Silberhumer, Gerd R. Hetz, Hubert Rasoul‐Rockenschaub, Susanne Peck‐Radosavljevic, Markus Soliman, Thomas Steininger, Rudolf Muehlbacher, Ferdinand Berlakovich, Gabriela A. |
| description | Summary
Model for end‐stage liver disease (MELD) score has emerged as a useful tool in predicting mortality in patients awaiting liver transplantation. There is still, however, discussion as to whether further parameters could improve the sensitivity and specificity of the MELD score. From 1997 to 2003, 621 adult patients with end‐stage liver disease were listed for orthotopic liver transplantation (OLT). Patients suffering from hepatoma were excluded from analysis (113 patients). The MELD score was investigated at the time of listing (MELD ON) and of coming off the list (MELD OFF). Patients who died while on the waiting list showed a significant increase in their MELD score during the waiting time (MELD ON: 21 ± 7 vs. MELD OFF: 28 ± 9) as well as a significantly higher MELD ON compared with patients who were transplanted (MELD ON: 16 ± 5 vs. MELD OFF: 17 ± 7) or removed from the waiting list (MELD ON: 16 ± 6 vs. MELD OFF: 12 ± 3). Multivariate analysis identified MELD ON, ascites and recurrent infection as independent risk factors for death on the waiting list (P |
| doi_str_mv | 10.1111/j.1432-2277.2006.00250.x |
| format | Article |
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Model for end‐stage liver disease (MELD) score has emerged as a useful tool in predicting mortality in patients awaiting liver transplantation. There is still, however, discussion as to whether further parameters could improve the sensitivity and specificity of the MELD score. From 1997 to 2003, 621 adult patients with end‐stage liver disease were listed for orthotopic liver transplantation (OLT). Patients suffering from hepatoma were excluded from analysis (113 patients). The MELD score was investigated at the time of listing (MELD ON) and of coming off the list (MELD OFF). Patients who died while on the waiting list showed a significant increase in their MELD score during the waiting time (MELD ON: 21 ± 7 vs. MELD OFF: 28 ± 9) as well as a significantly higher MELD ON compared with patients who were transplanted (MELD ON: 16 ± 5 vs. MELD OFF: 17 ± 7) or removed from the waiting list (MELD ON: 16 ± 6 vs. MELD OFF: 12 ± 3). Multivariate analysis identified MELD ON, ascites and recurrent infection as independent risk factors for death on the waiting list (P < 0.01). MELD score was not identified as a predictor for the post‐transplant survival rate. MELD score is a strong predictor for death on the waiting list, but refractory ascites and recurrent infection are independent risk factors, too.</description><identifier>ISSN: 0934-0874</identifier><identifier>EISSN: 1432-2277</identifier><identifier>DOI: 10.1111/j.1432-2277.2006.00250.x</identifier><identifier>PMID: 16573542</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adult ; Aged ; Female ; Humans ; Liver Failure - mortality ; Liver Failure - surgery ; liver transplantation ; Liver Transplantation - mortality ; Male ; MELD score ; Middle Aged ; Models, Biological ; Resource Allocation ; Risk Factors ; Survival Rate ; Tissue and Organ Procurement ; waiting list ; Waiting Lists</subject><ispartof>Transplant international, 2006-04, Vol.19 (4), p.275-281</ispartof><rights>Copyright Blackwell Publishing Ltd. Apr 2006</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3930-b87ecb9f9c0d55880e60f4ad23d771a5a8b3e600ebb7afed20900fec86d4c5473</citedby><cites>FETCH-LOGICAL-c3930-b87ecb9f9c0d55880e60f4ad23d771a5a8b3e600ebb7afed20900fec86d4c5473</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1432-2277.2006.00250.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1432-2277.2006.00250.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,27905,27906,45555,45556</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16573542$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Silberhumer, Gerd R.</creatorcontrib><creatorcontrib>Hetz, Hubert</creatorcontrib><creatorcontrib>Rasoul‐Rockenschaub, Susanne</creatorcontrib><creatorcontrib>Peck‐Radosavljevic, Markus</creatorcontrib><creatorcontrib>Soliman, Thomas</creatorcontrib><creatorcontrib>Steininger, Rudolf</creatorcontrib><creatorcontrib>Muehlbacher, Ferdinand</creatorcontrib><creatorcontrib>Berlakovich, Gabriela A.</creatorcontrib><title>Is MELD score sufficient to predict not only death on waiting list, but also post‐transplant survival?</title><title>Transplant international</title><addtitle>Transpl Int</addtitle><description>Summary
Model for end‐stage liver disease (MELD) score has emerged as a useful tool in predicting mortality in patients awaiting liver transplantation. There is still, however, discussion as to whether further parameters could improve the sensitivity and specificity of the MELD score. From 1997 to 2003, 621 adult patients with end‐stage liver disease were listed for orthotopic liver transplantation (OLT). Patients suffering from hepatoma were excluded from analysis (113 patients). The MELD score was investigated at the time of listing (MELD ON) and of coming off the list (MELD OFF). Patients who died while on the waiting list showed a significant increase in their MELD score during the waiting time (MELD ON: 21 ± 7 vs. MELD OFF: 28 ± 9) as well as a significantly higher MELD ON compared with patients who were transplanted (MELD ON: 16 ± 5 vs. MELD OFF: 17 ± 7) or removed from the waiting list (MELD ON: 16 ± 6 vs. MELD OFF: 12 ± 3). Multivariate analysis identified MELD ON, ascites and recurrent infection as independent risk factors for death on the waiting list (P < 0.01). MELD score was not identified as a predictor for the post‐transplant survival rate. MELD score is a strong predictor for death on the waiting list, but refractory ascites and recurrent infection are independent risk factors, too.</description><subject>Adult</subject><subject>Aged</subject><subject>Female</subject><subject>Humans</subject><subject>Liver Failure - mortality</subject><subject>Liver Failure - surgery</subject><subject>liver transplantation</subject><subject>Liver Transplantation - mortality</subject><subject>Male</subject><subject>MELD score</subject><subject>Middle Aged</subject><subject>Models, Biological</subject><subject>Resource Allocation</subject><subject>Risk Factors</subject><subject>Survival Rate</subject><subject>Tissue and Organ Procurement</subject><subject>waiting list</subject><subject>Waiting Lists</subject><issn>0934-0874</issn><issn>1432-2277</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkd9qFDEUxoModq2-ggQvvHLGk3-TDAgitdqFFUHqdchkMjbL7GRNMm33zkfwGX0Ss93FgldNLnI4-X0fh-8ghAnUpJy365pwRitKpawpQFMDUAH17SO0-PfxGC2gZbwCJfkJepbSGgqlBDxFJ6QRkglOF-hqmfCX89VHnGyIDqd5GLz1bso4B7yNrvc24ylkHKZxh3tn8lUp8Y3x2U8_8OhTfoO7OWMzpiIIKf_59TtHM6XtaIpLmuO1vzbj--foyVAY9-L4nqLvn84vzy6q1dfPy7MPq8qylkHVKels1w6thV4IpcA1MHDTU9ZLSYwwqmOlBa7rpBlcT6EFGJxVTc-t4JKdotcH320MP2eXst74ZN1YpnFhTrqRipTLC_jqP3Ad5jiV2TQlbUOJ4KRA6gDZGFKKbtDb6Dcm7jQBvV-FXut94nqfuN6vQt-tQt8W6cuj_9xtXH8vPGZfgHcH4MaPbvdgY335bVkK9hfA7piX</recordid><startdate>200604</startdate><enddate>200604</enddate><creator>Silberhumer, Gerd R.</creator><creator>Hetz, Hubert</creator><creator>Rasoul‐Rockenschaub, Susanne</creator><creator>Peck‐Radosavljevic, Markus</creator><creator>Soliman, Thomas</creator><creator>Steininger, Rudolf</creator><creator>Muehlbacher, Ferdinand</creator><creator>Berlakovich, Gabriela A.</creator><general>Blackwell Publishing Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7T5</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>200604</creationdate><title>Is MELD score sufficient to predict not only death on waiting list, but also post‐transplant survival?</title><author>Silberhumer, Gerd R. ; Hetz, Hubert ; Rasoul‐Rockenschaub, Susanne ; Peck‐Radosavljevic, Markus ; Soliman, Thomas ; Steininger, Rudolf ; Muehlbacher, Ferdinand ; Berlakovich, Gabriela A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3930-b87ecb9f9c0d55880e60f4ad23d771a5a8b3e600ebb7afed20900fec86d4c5473</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Female</topic><topic>Humans</topic><topic>Liver Failure - mortality</topic><topic>Liver Failure - surgery</topic><topic>liver transplantation</topic><topic>Liver Transplantation - mortality</topic><topic>Male</topic><topic>MELD score</topic><topic>Middle Aged</topic><topic>Models, Biological</topic><topic>Resource Allocation</topic><topic>Risk Factors</topic><topic>Survival Rate</topic><topic>Tissue and Organ Procurement</topic><topic>waiting list</topic><topic>Waiting Lists</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Silberhumer, Gerd R.</creatorcontrib><creatorcontrib>Hetz, Hubert</creatorcontrib><creatorcontrib>Rasoul‐Rockenschaub, Susanne</creatorcontrib><creatorcontrib>Peck‐Radosavljevic, Markus</creatorcontrib><creatorcontrib>Soliman, Thomas</creatorcontrib><creatorcontrib>Steininger, Rudolf</creatorcontrib><creatorcontrib>Muehlbacher, Ferdinand</creatorcontrib><creatorcontrib>Berlakovich, Gabriela A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Immunology Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Transplant international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Silberhumer, Gerd R.</au><au>Hetz, Hubert</au><au>Rasoul‐Rockenschaub, Susanne</au><au>Peck‐Radosavljevic, Markus</au><au>Soliman, Thomas</au><au>Steininger, Rudolf</au><au>Muehlbacher, Ferdinand</au><au>Berlakovich, Gabriela A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Is MELD score sufficient to predict not only death on waiting list, but also post‐transplant survival?</atitle><jtitle>Transplant international</jtitle><addtitle>Transpl Int</addtitle><date>2006-04</date><risdate>2006</risdate><volume>19</volume><issue>4</issue><spage>275</spage><epage>281</epage><pages>275-281</pages><issn>0934-0874</issn><eissn>1432-2277</eissn><abstract>Summary
Model for end‐stage liver disease (MELD) score has emerged as a useful tool in predicting mortality in patients awaiting liver transplantation. There is still, however, discussion as to whether further parameters could improve the sensitivity and specificity of the MELD score. From 1997 to 2003, 621 adult patients with end‐stage liver disease were listed for orthotopic liver transplantation (OLT). Patients suffering from hepatoma were excluded from analysis (113 patients). The MELD score was investigated at the time of listing (MELD ON) and of coming off the list (MELD OFF). Patients who died while on the waiting list showed a significant increase in their MELD score during the waiting time (MELD ON: 21 ± 7 vs. MELD OFF: 28 ± 9) as well as a significantly higher MELD ON compared with patients who were transplanted (MELD ON: 16 ± 5 vs. MELD OFF: 17 ± 7) or removed from the waiting list (MELD ON: 16 ± 6 vs. MELD OFF: 12 ± 3). Multivariate analysis identified MELD ON, ascites and recurrent infection as independent risk factors for death on the waiting list (P < 0.01). MELD score was not identified as a predictor for the post‐transplant survival rate. MELD score is a strong predictor for death on the waiting list, but refractory ascites and recurrent infection are independent risk factors, too.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>16573542</pmid><doi>10.1111/j.1432-2277.2006.00250.x</doi><tpages>7</tpages></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adult Aged Female Humans Liver Failure - mortality Liver Failure - surgery liver transplantation Liver Transplantation - mortality Male MELD score Middle Aged Models, Biological Resource Allocation Risk Factors Survival Rate Tissue and Organ Procurement waiting list Waiting Lists |
| title | Is MELD score sufficient to predict not only death on waiting list, but also post‐transplant survival? |
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