Focal adhesion kinase-related protein tyrosine kinase Pyk2 in T-cell activation and function
Pyk2 is a protein tyrosine kinase expressed primarily in brain and hematopoietic cells. It becomes activated in response to stimulation through numerous receptors, including integrins, chemokine receptors, and antigen receptors, and is found in association with src-family kinases. Although this enzy...
Gespeichert in:
| Veröffentlicht in: | Immunologic research 2005-01, Vol.31 (3), p.267-282 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 282 |
|---|---|
| container_issue | 3 |
| container_start_page | 267 |
| container_title | Immunologic research |
| container_volume | 31 |
| creator | Ostergaard, Hanne L Lysechko, Tara L |
| description | Pyk2 is a protein tyrosine kinase expressed primarily in brain and hematopoietic cells. It becomes activated in response to stimulation through numerous receptors, including integrins, chemokine receptors, and antigen receptors, and is found in association with src-family kinases. Although this enzyme associates with many proteins known to be important for activation and has many characteristics of a scaffolding protein, its function remains elusive. A number of studies in non-T-cells suggest that Pyk2 is important for cell spreading, cell migration, and integrin function; however, a defined role in T-cells has not been established. Here, we discuss evidence that implicates Pyk2 in directionality of signaling, which is essential to establishment of the directional killing mediated by cytotoxic lymphocytes. |
| doi_str_mv | 10.1385/IR:31:3:267 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_67817531</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1940629171</sourcerecordid><originalsourceid>FETCH-LOGICAL-c314t-c5e09aad7e1f4929ac0124abda2de7242ae28c109f6d0210f5f58f30967f4df43</originalsourceid><addsrcrecordid>eNpdkM1LAzEQxYMotlZP3mXx4EVW87HZJL1JsVooKKWCByGk-cBtt9m62RX635ulC4qnTGZ-83jzALhE8A4RTu9nizFBYzLGOTsCQ4gpSzFj78d_6gE4C2ENIcqzjJyCAaKcc4HYEHxMK63KRJlPG4rKJ5vCq2DT2paqsSbZ1VVjC580-7oKhbf9PHndb3AS-8tU2zKu66b4Vk0noLxJXOt19zkHJ06VwV707wi8TR-Xk-d0_vI0mzzMU01Q1qSaWiiUMswilwkslIYIZ2plFDaW4Qwri7lGULjcQIygo45yR6DImcuMy8gI3Bx0o92v1oZGbovQGVPeVm2QOeOIUYIieP0PXFdt7aM3iQTlIqeQRuj2AOl4c6itk7u62Kp6LxGUXeJytpAESSJj4pG-6iXb1daaX7aPmPwAGJ98Bg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>195896505</pqid></control><display><type>article</type><title>Focal adhesion kinase-related protein tyrosine kinase Pyk2 in T-cell activation and function</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Ostergaard, Hanne L ; Lysechko, Tara L</creator><creatorcontrib>Ostergaard, Hanne L ; Lysechko, Tara L</creatorcontrib><description>Pyk2 is a protein tyrosine kinase expressed primarily in brain and hematopoietic cells. It becomes activated in response to stimulation through numerous receptors, including integrins, chemokine receptors, and antigen receptors, and is found in association with src-family kinases. Although this enzyme associates with many proteins known to be important for activation and has many characteristics of a scaffolding protein, its function remains elusive. A number of studies in non-T-cells suggest that Pyk2 is important for cell spreading, cell migration, and integrin function; however, a defined role in T-cells has not been established. Here, we discuss evidence that implicates Pyk2 in directionality of signaling, which is essential to establishment of the directional killing mediated by cytotoxic lymphocytes.</description><identifier>ISSN: 0257-277X</identifier><identifier>EISSN: 0257-277X</identifier><identifier>EISSN: 1559-0755</identifier><identifier>DOI: 10.1385/IR:31:3:267</identifier><identifier>PMID: 15888917</identifier><language>eng</language><publisher>United States: Springer Nature B.V</publisher><subject>Animals ; Cell adhesion & migration ; Cell Movement ; Cell Shape ; Cellular biology ; Enzyme Activation ; Focal Adhesion Kinase 2 - physiology ; Humans ; Immunology ; Kinases ; Lymphocytes ; Models, Biological ; Proteins ; Signal Transduction ; T cell receptors ; T-Lymphocytes - physiology</subject><ispartof>Immunologic research, 2005-01, Vol.31 (3), p.267-282</ispartof><rights>Humana Press Inc. 2005</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c314t-c5e09aad7e1f4929ac0124abda2de7242ae28c109f6d0210f5f58f30967f4df43</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15888917$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ostergaard, Hanne L</creatorcontrib><creatorcontrib>Lysechko, Tara L</creatorcontrib><title>Focal adhesion kinase-related protein tyrosine kinase Pyk2 in T-cell activation and function</title><title>Immunologic research</title><addtitle>Immunol Res</addtitle><description>Pyk2 is a protein tyrosine kinase expressed primarily in brain and hematopoietic cells. It becomes activated in response to stimulation through numerous receptors, including integrins, chemokine receptors, and antigen receptors, and is found in association with src-family kinases. Although this enzyme associates with many proteins known to be important for activation and has many characteristics of a scaffolding protein, its function remains elusive. A number of studies in non-T-cells suggest that Pyk2 is important for cell spreading, cell migration, and integrin function; however, a defined role in T-cells has not been established. Here, we discuss evidence that implicates Pyk2 in directionality of signaling, which is essential to establishment of the directional killing mediated by cytotoxic lymphocytes.</description><subject>Animals</subject><subject>Cell adhesion & migration</subject><subject>Cell Movement</subject><subject>Cell Shape</subject><subject>Cellular biology</subject><subject>Enzyme Activation</subject><subject>Focal Adhesion Kinase 2 - physiology</subject><subject>Humans</subject><subject>Immunology</subject><subject>Kinases</subject><subject>Lymphocytes</subject><subject>Models, Biological</subject><subject>Proteins</subject><subject>Signal Transduction</subject><subject>T cell receptors</subject><subject>T-Lymphocytes - physiology</subject><issn>0257-277X</issn><issn>0257-277X</issn><issn>1559-0755</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNpdkM1LAzEQxYMotlZP3mXx4EVW87HZJL1JsVooKKWCByGk-cBtt9m62RX635ulC4qnTGZ-83jzALhE8A4RTu9nizFBYzLGOTsCQ4gpSzFj78d_6gE4C2ENIcqzjJyCAaKcc4HYEHxMK63KRJlPG4rKJ5vCq2DT2paqsSbZ1VVjC580-7oKhbf9PHndb3AS-8tU2zKu66b4Vk0noLxJXOt19zkHJ06VwV707wi8TR-Xk-d0_vI0mzzMU01Q1qSaWiiUMswilwkslIYIZ2plFDaW4Qwri7lGULjcQIygo45yR6DImcuMy8gI3Bx0o92v1oZGbovQGVPeVm2QOeOIUYIieP0PXFdt7aM3iQTlIqeQRuj2AOl4c6itk7u62Kp6LxGUXeJytpAESSJj4pG-6iXb1daaX7aPmPwAGJ98Bg</recordid><startdate>20050101</startdate><enddate>20050101</enddate><creator>Ostergaard, Hanne L</creator><creator>Lysechko, Tara L</creator><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>20050101</creationdate><title>Focal adhesion kinase-related protein tyrosine kinase Pyk2 in T-cell activation and function</title><author>Ostergaard, Hanne L ; Lysechko, Tara L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c314t-c5e09aad7e1f4929ac0124abda2de7242ae28c109f6d0210f5f58f30967f4df43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Animals</topic><topic>Cell adhesion & migration</topic><topic>Cell Movement</topic><topic>Cell Shape</topic><topic>Cellular biology</topic><topic>Enzyme Activation</topic><topic>Focal Adhesion Kinase 2 - physiology</topic><topic>Humans</topic><topic>Immunology</topic><topic>Kinases</topic><topic>Lymphocytes</topic><topic>Models, Biological</topic><topic>Proteins</topic><topic>Signal Transduction</topic><topic>T cell receptors</topic><topic>T-Lymphocytes - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ostergaard, Hanne L</creatorcontrib><creatorcontrib>Lysechko, Tara L</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Immunologic research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ostergaard, Hanne L</au><au>Lysechko, Tara L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Focal adhesion kinase-related protein tyrosine kinase Pyk2 in T-cell activation and function</atitle><jtitle>Immunologic research</jtitle><addtitle>Immunol Res</addtitle><date>2005-01-01</date><risdate>2005</risdate><volume>31</volume><issue>3</issue><spage>267</spage><epage>282</epage><pages>267-282</pages><issn>0257-277X</issn><eissn>0257-277X</eissn><eissn>1559-0755</eissn><abstract>Pyk2 is a protein tyrosine kinase expressed primarily in brain and hematopoietic cells. It becomes activated in response to stimulation through numerous receptors, including integrins, chemokine receptors, and antigen receptors, and is found in association with src-family kinases. Although this enzyme associates with many proteins known to be important for activation and has many characteristics of a scaffolding protein, its function remains elusive. A number of studies in non-T-cells suggest that Pyk2 is important for cell spreading, cell migration, and integrin function; however, a defined role in T-cells has not been established. Here, we discuss evidence that implicates Pyk2 in directionality of signaling, which is essential to establishment of the directional killing mediated by cytotoxic lymphocytes.</abstract><cop>United States</cop><pub>Springer Nature B.V</pub><pmid>15888917</pmid><doi>10.1385/IR:31:3:267</doi><tpages>16</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0257-277X |
| ispartof | Immunologic research, 2005-01, Vol.31 (3), p.267-282 |
| issn | 0257-277X 0257-277X 1559-0755 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_67817531 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Animals Cell adhesion & migration Cell Movement Cell Shape Cellular biology Enzyme Activation Focal Adhesion Kinase 2 - physiology Humans Immunology Kinases Lymphocytes Models, Biological Proteins Signal Transduction T cell receptors T-Lymphocytes - physiology |
| title | Focal adhesion kinase-related protein tyrosine kinase Pyk2 in T-cell activation and function |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-04T19%3A27%3A19IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Focal%20adhesion%20kinase-related%20protein%20tyrosine%20kinase%20Pyk2%20in%20T-cell%20activation%20and%20function&rft.jtitle=Immunologic%20research&rft.au=Ostergaard,%20Hanne%20L&rft.date=2005-01-01&rft.volume=31&rft.issue=3&rft.spage=267&rft.epage=282&rft.pages=267-282&rft.issn=0257-277X&rft.eissn=0257-277X&rft_id=info:doi/10.1385/IR:31:3:267&rft_dat=%3Cproquest_cross%3E1940629171%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=195896505&rft_id=info:pmid/15888917&rfr_iscdi=true |