Evidence that variation in the peripheral benzodiazepine receptor (PBR) gene influences susceptibility to panic disorder
Panic disorder (PD) is the repeated sudden occurrence of panic attacks, episodes characterized by psychological symptoms. Peripheral benzodiazepine receptor (PBR) is closely associated with personality traits for anxiety tolerance, and that it holds promise as a biological marker of stressful condit...
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| Veröffentlicht in: | American journal of medical genetics. Part B, Neuropsychiatric genetics Neuropsychiatric genetics, 2006-04, Vol.141B (3), p.222-226 |
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| container_title | American journal of medical genetics. Part B, Neuropsychiatric genetics |
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| creator | Nakamura, Kazuhiko Yamada, Kazuo Iwayama, Yoshimi Toyota, Tomoko Furukawa, Aizou Takimoto, Takahiro Terayama, Hayato Iwahashi, Kazuhiko Takei, Nori Minabe, Yoshio Sekine, Yoshimoto Suzuki, Katsuaki Iwata, Yasuhide Pillai, Anitha Nakamoto, Yurie Ikeda, Kazutaka Yoshii, Mitsunobu Fukunishi, Isao Yoshikawa, Takeo Mori, Norio |
| description | Panic disorder (PD) is the repeated sudden occurrence of panic attacks, episodes characterized by psychological symptoms. Peripheral benzodiazepine receptor (PBR) is closely associated with personality traits for anxiety tolerance, and that it holds promise as a biological marker of stressful conditions. We have performed association analyses using the polymorphism to determine the PBR in PD. We screened the subjects for sequence variations within the 5′ region, the coding region (exons 2–4), and the 3′ noncoding region. One novel missense variant in exon 4, derived from the nucleotide transition in codon 162 (CGT → CAT:485G > A) resulting in an arginine‐to‐histidine (Arg → His) change, was detected in these subjects. The 485G > polymorphism of the PBR gene was analyzed in 91 PD patients and 178 controls. The genotypic and allelic analyses of the 485G > A revealed significant differences between the panic patients and the comparison subjects (P = 0.021 and 0.014, respectively). The present study provides new and important evidence that variation in the PBR gene influences susceptibility to PD. © 2006 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/ajmg.b.30211 |
| format | Article |
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Peripheral benzodiazepine receptor (PBR) is closely associated with personality traits for anxiety tolerance, and that it holds promise as a biological marker of stressful conditions. We have performed association analyses using the polymorphism to determine the PBR in PD. We screened the subjects for sequence variations within the 5′ region, the coding region (exons 2–4), and the 3′ noncoding region. One novel missense variant in exon 4, derived from the nucleotide transition in codon 162 (CGT → CAT:485G > A) resulting in an arginine‐to‐histidine (Arg → His) change, was detected in these subjects. The 485G > polymorphism of the PBR gene was analyzed in 91 PD patients and 178 controls. The genotypic and allelic analyses of the 485G > A revealed significant differences between the panic patients and the comparison subjects (P = 0.021 and 0.014, respectively). The present study provides new and important evidence that variation in the PBR gene influences susceptibility to PD. © 2006 Wiley‐Liss, Inc.</description><identifier>ISSN: 1552-4841</identifier><identifier>EISSN: 1552-485X</identifier><identifier>DOI: 10.1002/ajmg.b.30211</identifier><identifier>PMID: 16511838</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Alleles ; Base Sequence ; Biological and medical sciences ; DNA Mutational Analysis ; Female ; Gene Frequency ; Genetic Predisposition to Disease - genetics ; Genotype ; Humans ; Male ; Medical genetics ; Medical sciences ; Middle Aged ; Mutation ; Mutation, Missense ; panic disorder ; Panic Disorder - genetics ; peripheral benzodiazepine receptor ; polymorphism ; Polymorphism, Single Nucleotide ; Receptors, GABA-A - genetics</subject><ispartof>American journal of medical genetics. 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Part B, Neuropsychiatric genetics</title><addtitle>Am. J. Med. Genet</addtitle><description>Panic disorder (PD) is the repeated sudden occurrence of panic attacks, episodes characterized by psychological symptoms. Peripheral benzodiazepine receptor (PBR) is closely associated with personality traits for anxiety tolerance, and that it holds promise as a biological marker of stressful conditions. We have performed association analyses using the polymorphism to determine the PBR in PD. We screened the subjects for sequence variations within the 5′ region, the coding region (exons 2–4), and the 3′ noncoding region. One novel missense variant in exon 4, derived from the nucleotide transition in codon 162 (CGT → CAT:485G > A) resulting in an arginine‐to‐histidine (Arg → His) change, was detected in these subjects. The 485G > polymorphism of the PBR gene was analyzed in 91 PD patients and 178 controls. The genotypic and allelic analyses of the 485G > A revealed significant differences between the panic patients and the comparison subjects (P = 0.021 and 0.014, respectively). The present study provides new and important evidence that variation in the PBR gene influences susceptibility to PD. © 2006 Wiley‐Liss, Inc.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Alleles</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>DNA Mutational Analysis</subject><subject>Female</subject><subject>Gene Frequency</subject><subject>Genetic Predisposition to Disease - genetics</subject><subject>Genotype</subject><subject>Humans</subject><subject>Male</subject><subject>Medical genetics</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Mutation</subject><subject>Mutation, Missense</subject><subject>panic disorder</subject><subject>Panic Disorder - genetics</subject><subject>peripheral benzodiazepine receptor</subject><subject>polymorphism</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Receptors, GABA-A - genetics</subject><issn>1552-4841</issn><issn>1552-485X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1v1DAQhi1ERcvCjTPyBQRSs9ixEzvHsipb0LIUVD5u1iSetG6zTrCT0u2vb5Zd2hunGc08887MS8gLzqacsfQdXK7Op-VUsJTzR-SAZ1maSJ39enyfS75PnsZ4yZhgmVJPyD7PM8610Afk5vjaWfQV0v4CenoNwUHvWk-dHytIOwyuu8AADS3R37bWwS12ziMNWGHXt4G-OX3_7S09x7HmfN0MG7VI4xA3fVe6xvVr2re0A-8qal1sg8XwjOzV0ER8vosT8v3D8dnsJFl8mX-cHS2SSjLOEwV1zepS8yrXPNciQw1Qc6lBWJvKTFoQstCaFxpYbQsrUqvStJAoRCULKSbk9Va3C-3vAWNvVm68rGnAYztEkyvNFRuVJ-RwC1ahjTFgbbrgVhDWhjOzcdpsnDal-ev0iL_c6Q7lCu0DvLN2BF7tAIgVNHUAX7n4wKlc8VQWIye23B_X4Pq_S83Rp8_zf-uT7ZSLPd7cT0G4Gj8SKjM_l3Oz_LGYLb9mp-ZM3AFyyqf0</recordid><startdate>20060405</startdate><enddate>20060405</enddate><creator>Nakamura, Kazuhiko</creator><creator>Yamada, Kazuo</creator><creator>Iwayama, Yoshimi</creator><creator>Toyota, Tomoko</creator><creator>Furukawa, Aizou</creator><creator>Takimoto, Takahiro</creator><creator>Terayama, Hayato</creator><creator>Iwahashi, Kazuhiko</creator><creator>Takei, Nori</creator><creator>Minabe, Yoshio</creator><creator>Sekine, Yoshimoto</creator><creator>Suzuki, Katsuaki</creator><creator>Iwata, Yasuhide</creator><creator>Pillai, Anitha</creator><creator>Nakamoto, Yurie</creator><creator>Ikeda, Kazutaka</creator><creator>Yoshii, Mitsunobu</creator><creator>Fukunishi, Isao</creator><creator>Yoshikawa, Takeo</creator><creator>Mori, Norio</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20060405</creationdate><title>Evidence that variation in the peripheral benzodiazepine receptor (PBR) gene influences susceptibility to panic disorder</title><author>Nakamura, Kazuhiko ; 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Genet</addtitle><date>2006-04-05</date><risdate>2006</risdate><volume>141B</volume><issue>3</issue><spage>222</spage><epage>226</epage><pages>222-226</pages><issn>1552-4841</issn><eissn>1552-485X</eissn><abstract>Panic disorder (PD) is the repeated sudden occurrence of panic attacks, episodes characterized by psychological symptoms. Peripheral benzodiazepine receptor (PBR) is closely associated with personality traits for anxiety tolerance, and that it holds promise as a biological marker of stressful conditions. We have performed association analyses using the polymorphism to determine the PBR in PD. We screened the subjects for sequence variations within the 5′ region, the coding region (exons 2–4), and the 3′ noncoding region. One novel missense variant in exon 4, derived from the nucleotide transition in codon 162 (CGT → CAT:485G > A) resulting in an arginine‐to‐histidine (Arg → His) change, was detected in these subjects. The 485G > polymorphism of the PBR gene was analyzed in 91 PD patients and 178 controls. The genotypic and allelic analyses of the 485G > A revealed significant differences between the panic patients and the comparison subjects (P = 0.021 and 0.014, respectively). The present study provides new and important evidence that variation in the PBR gene influences susceptibility to PD. © 2006 Wiley‐Liss, Inc.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>16511838</pmid><doi>10.1002/ajmg.b.30211</doi><tpages>5</tpages></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Alleles Base Sequence Biological and medical sciences DNA Mutational Analysis Female Gene Frequency Genetic Predisposition to Disease - genetics Genotype Humans Male Medical genetics Medical sciences Middle Aged Mutation Mutation, Missense panic disorder Panic Disorder - genetics peripheral benzodiazepine receptor polymorphism Polymorphism, Single Nucleotide Receptors, GABA-A - genetics |
| title | Evidence that variation in the peripheral benzodiazepine receptor (PBR) gene influences susceptibility to panic disorder |
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