Blockade of nicotinic receptors of bovine adrenal chromaffin cells by nanomolar concentrations of atropine

Nanomolar concentrations of atropine have been considered up to now to be selective for blockade of muscarinic receptors for acetylcholine. A collateral finding indicated to us that these low concentrations of atropine could also target the neuronal nicotinic receptors. We report here a detailed stu...

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Veröffentlicht in:	European journal of pharmacology 2006-03, Vol.535 (1), p.13-24
Hauptverfasser:	González-Rubio, Juana M a, García de Diego, Antonio M., Egea, Javier, Olivares, Román, Rojo, Jonathan, Gandía, Luis, García, Antonio G., Hernández-Guijo, Jesús M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine - pharmacology Adrenal Medulla - cytology alpha7 Nicotinic Acetylcholine Receptor Animals Atropine Atropine - pharmacology Biological and medical sciences Bovine chromaffin cell Calcium - metabolism Calcium Channels - physiology Catecholamines - secretion Cattle Cells, Cultured Chromaffin Cells - drug effects Chromaffin Cells - metabolism Chromaffin Cells - physiology Cytosol - drug effects Cytosol - metabolism Dimethylphenylpiperazinium Iodide - pharmacology Dose-Response Relationship, Drug Female Gene Expression Medical sciences Membrane Potentials - drug effects Microchemistry Muscarinic Antagonists - pharmacology Nicotinic Agonists - pharmacology Nicotinic Antagonists - pharmacology Nicotinic receptor Oocytes - drug effects Oocytes - metabolism Oocytes - physiology Pharmacology. Drug treatments Receptors, Muscarinic - physiology Receptors, Nicotinic - genetics Receptors, Nicotinic - physiology Xenopus laevis
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