Synthesis and antiproliferative activity of two new tiazofurin analogues with 2′-amido functionalities

Two novel tiazofurin analogues 2 and 3 were synthesized starting from d-glucose. The key step of the synthesis was the efficient one-step hydrogen sulfide-mediated conversion of 2-azido-3-O-acyl-ribofuranosyl cyanides to the corresponding 2-amido thiocarboxamides. Compounds 2 and 3 were evaluated fo...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2006-05, Vol.16 (10), p.2773-2776
Hauptverfasser:	Popsavin, Mirjana, Torović, Ljilja, Svirčev, Miloš, Kojić, Vesna, Bogdanović, Gordana, Popsavin, Velimir
Format:	Artikel
Sprache:	eng
Schlagworte:	2,5-Anhydro sugars Amides - chemistry Antineoplastic agents Antineoplastic Agents - chemical synthesis Antineoplastic Agents - pharmacology Antitumour agents Biological and medical sciences C-Nucleosides Cell Line, Tumor Cell Proliferation - drug effects De novo synthesis General aspects Humans Medical sciences Pharmacology. Drug treatments Ribavirin - analogs & derivatives Ribavirin - chemical synthesis Ribavirin - chemistry Ribavirin - pharmacology Thiazoles Tiazofurin analogues
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