Association of human hippocampal neurochemistry, serotonin transporter genetic variation, and anxiety
The impact of the serotonin transporter (5-HTT) gene-linked polymorphic region (5-HTTLPR) on anxiety-related behavior and related cerebral activation has facilitated the understanding of neurobiological mechanisms of anxiety. However, the influence of the 5-HTTLPR genotype on hippocampal neuronal de...
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| Veröffentlicht in: | NeuroImage (Orlando, Fla.) Fla.), 2005-05, Vol.26 (1), p.123-131 |
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| creator | Gallinat, Jürgen Ströhle, Andreas Lang, Undine E. Bajbouj, Malek Kalus, Peter Montag, Christiane Seifert, Frank Wernicke, Catrin Rommelspacher, Hans Rinneberg, Herbert Schubert, Florian |
| description | The impact of the serotonin transporter (5-HTT) gene-linked polymorphic region (5-HTTLPR) on anxiety-related behavior and related cerebral activation has facilitated the understanding of neurobiological mechanisms of anxiety. However, the influence of the 5-HTTLPR genotype on hippocampal neuronal development and neurochemistry, which is relevant to anxiety behavior, has not been investigated. In 38 healthy subjects, absolute concentrations of N-acetylaspartate (NAA) were measured as a main surrogate parameter for hippocampal neurochemistry on a 3-T scanner. A significantly lower hippocampal NAA concentration in s allele carriers was observed as compared to l/l genotype. Other metabolites (choline, creatine + phosphocreatine, glutamate) were unaffected by genotype. The hippocampal NAA concentration was negatively correlated with trait anxiety scores (STAI). Metabolites measured in the anterior cingulate cortex (reference region) were not associated with genotype. The results are in accordance with the recently reported relationship between hippocampal neuronal development and anxiety behavior in adult animals and show an association between human limbic neurochemistry and genetically driven serotonergic neurotransmission relevant to anxiety. |
| doi_str_mv | 10.1016/j.neuroimage.2005.01.001 |
| format | Article |
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The results are in accordance with the recently reported relationship between hippocampal neuronal development and anxiety behavior in adult animals and show an association between human limbic neurochemistry and genetically driven serotonergic neurotransmission relevant to anxiety.</description><identifier>ISSN: 1053-8119</identifier><identifier>EISSN: 1095-9572</identifier><identifier>DOI: 10.1016/j.neuroimage.2005.01.001</identifier><identifier>PMID: 15862212</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Alleles ; Anxiety ; Anxiety - genetics ; Anxiety - metabolism ; Anxiety - psychology ; Aspartic Acid - analogs & derivatives ; Aspartic Acid - metabolism ; Behavior ; Biomarkers ; Brain ; DNA - genetics ; Genotype ; Gyrus Cinguli - metabolism ; Gyrus Cinguli - physiology ; Hippocampus - chemistry ; Hippocampus - metabolism ; Human hippocampal neurochemistry ; Humans ; Magnetic Resonance Imaging ; Magnetic resonance spectroscopy ; Membrane Glycoproteins - genetics ; Membrane Transport Proteins - genetics ; Nerve Tissue Proteins - genetics ; Neurochemistry ; Psychiatric Status Rating Scales ; Serotonin ; Serotonin Plasma Membrane Transport Proteins ; Serotonin transporter genetic variation ; Spectrum analysis ; Studies ; Synapses - physiology</subject><ispartof>NeuroImage (Orlando, Fla.), 2005-05, Vol.26 (1), p.123-131</ispartof><rights>2005 Elsevier Inc.</rights><rights>Copyright Elsevier Limited May 15, 2005</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c400t-9654c47e5371ed8ffccfbfb37776126801e048a60536c60cffb45463aa6ad80c3</citedby><cites>FETCH-LOGICAL-c400t-9654c47e5371ed8ffccfbfb37776126801e048a60536c60cffb45463aa6ad80c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1506638416?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,45974,64362,64364,64366,72216</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15862212$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gallinat, Jürgen</creatorcontrib><creatorcontrib>Ströhle, Andreas</creatorcontrib><creatorcontrib>Lang, Undine E.</creatorcontrib><creatorcontrib>Bajbouj, Malek</creatorcontrib><creatorcontrib>Kalus, Peter</creatorcontrib><creatorcontrib>Montag, Christiane</creatorcontrib><creatorcontrib>Seifert, Frank</creatorcontrib><creatorcontrib>Wernicke, Catrin</creatorcontrib><creatorcontrib>Rommelspacher, Hans</creatorcontrib><creatorcontrib>Rinneberg, Herbert</creatorcontrib><creatorcontrib>Schubert, Florian</creatorcontrib><title>Association of human hippocampal neurochemistry, serotonin transporter genetic variation, and anxiety</title><title>NeuroImage (Orlando, Fla.)</title><addtitle>Neuroimage</addtitle><description>The impact of the serotonin transporter (5-HTT) gene-linked polymorphic region (5-HTTLPR) on anxiety-related behavior and related cerebral activation has facilitated the understanding of neurobiological mechanisms of anxiety. 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The results are in accordance with the recently reported relationship between hippocampal neuronal development and anxiety behavior in adult animals and show an association between human limbic neurochemistry and genetically driven serotonergic neurotransmission relevant to anxiety.</description><subject>Alleles</subject><subject>Anxiety</subject><subject>Anxiety - genetics</subject><subject>Anxiety - metabolism</subject><subject>Anxiety - psychology</subject><subject>Aspartic Acid - analogs & derivatives</subject><subject>Aspartic Acid - metabolism</subject><subject>Behavior</subject><subject>Biomarkers</subject><subject>Brain</subject><subject>DNA - genetics</subject><subject>Genotype</subject><subject>Gyrus Cinguli - metabolism</subject><subject>Gyrus Cinguli - physiology</subject><subject>Hippocampus - chemistry</subject><subject>Hippocampus - metabolism</subject><subject>Human hippocampal neurochemistry</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging</subject><subject>Magnetic resonance spectroscopy</subject><subject>Membrane Glycoproteins - 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However, the influence of the 5-HTTLPR genotype on hippocampal neuronal development and neurochemistry, which is relevant to anxiety behavior, has not been investigated. In 38 healthy subjects, absolute concentrations of N-acetylaspartate (NAA) were measured as a main surrogate parameter for hippocampal neurochemistry on a 3-T scanner. A significantly lower hippocampal NAA concentration in s allele carriers was observed as compared to l/l genotype. Other metabolites (choline, creatine + phosphocreatine, glutamate) were unaffected by genotype. The hippocampal NAA concentration was negatively correlated with trait anxiety scores (STAI). Metabolites measured in the anterior cingulate cortex (reference region) were not associated with genotype. 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| subjects | Alleles Anxiety Anxiety - genetics Anxiety - metabolism Anxiety - psychology Aspartic Acid - analogs & derivatives Aspartic Acid - metabolism Behavior Biomarkers Brain DNA - genetics Genotype Gyrus Cinguli - metabolism Gyrus Cinguli - physiology Hippocampus - chemistry Hippocampus - metabolism Human hippocampal neurochemistry Humans Magnetic Resonance Imaging Magnetic resonance spectroscopy Membrane Glycoproteins - genetics Membrane Transport Proteins - genetics Nerve Tissue Proteins - genetics Neurochemistry Psychiatric Status Rating Scales Serotonin Serotonin Plasma Membrane Transport Proteins Serotonin transporter genetic variation Spectrum analysis Studies Synapses - physiology |
| title | Association of human hippocampal neurochemistry, serotonin transporter genetic variation, and anxiety |
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