Occult hepatitis B virus infection in hematopoietic stem cell donors in a hepatitis B virus endemic area
The acquisition of hepatitis B virus (HBV) infection following organ transplantation from donors with occult HBV infection is an important cause of morbidity and mortality. The aim of this study is to determine the prevalence of occult HBV in allogeneic hematopoietic stem cell (HSC) transplantation...
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| Veröffentlicht in: | Journal of hepatology 2005-06, Vol.42 (6), p.813-819 |
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| container_title | Journal of hepatology |
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| creator | Hui, Chee-kin Sun, Jian Au, Wing-yan Lie, Albert K.W. Yueng, Yui-hung Zhang, Hai-ying Lee, Nikki P. Hou, Jin-ling Liang, Raymond Lau, George K.K. |
| description | The acquisition of hepatitis B virus (HBV) infection following organ transplantation from donors with occult HBV infection is an important cause of morbidity and mortality. The aim of this study is to determine the prevalence of occult HBV in allogeneic hematopoietic stem cell (HSC) transplantation donors.
We performed a retrospective study on 124 consecutive hepatitis B surface antigen negative HSC donors. Their serum samples were analyzed by PCR for the pre-S/S, pre-core/core and X regions of the virus. Samples reactive by at least two PCR assays were considered HBV-DNA positive.
Nineteen of the 124 HSC donors (15.3%) had occult HBV infection. Sixteen of these 19 donors with occult HBV infection (84.2%) tested positive for hepatitis B core antibody while 78 of 105 subjects (74.3%) without occult HBV infection were also positive (
P=0.56). Fourteen of the 19 donors (73.7%) with occult HBV infection tested positive for hepatitis B surface antibody while 67 of the 105 subjects without occult HBV infection were also positive (
P=0.45).
The prevalence of occult HBV infection among HSC donors in Hong Kong is high. Anti-HBc and anti-HBs status had no significant correlation with the presence of occult HBV infection. |
| doi_str_mv | 10.1016/j.jhep.2005.01.018 |
| format | Article |
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We performed a retrospective study on 124 consecutive hepatitis B surface antigen negative HSC donors. Their serum samples were analyzed by PCR for the pre-S/S, pre-core/core and X regions of the virus. Samples reactive by at least two PCR assays were considered HBV-DNA positive.
Nineteen of the 124 HSC donors (15.3%) had occult HBV infection. Sixteen of these 19 donors with occult HBV infection (84.2%) tested positive for hepatitis B core antibody while 78 of 105 subjects (74.3%) without occult HBV infection were also positive (
P=0.56). Fourteen of the 19 donors (73.7%) with occult HBV infection tested positive for hepatitis B surface antibody while 67 of the 105 subjects without occult HBV infection were also positive (
P=0.45).
The prevalence of occult HBV infection among HSC donors in Hong Kong is high. Anti-HBc and anti-HBs status had no significant correlation with the presence of occult HBV infection.</description><identifier>ISSN: 0168-8278</identifier><identifier>EISSN: 1600-0641</identifier><identifier>DOI: 10.1016/j.jhep.2005.01.018</identifier><identifier>PMID: 15885351</identifier><identifier>CODEN: JOHEEC</identifier><language>eng</language><publisher>Oxford: Elsevier B.V</publisher><subject>Adult ; Biological and medical sciences ; Blood Donors - statistics & numerical data ; Carrier State - epidemiology ; DNA, Viral - blood ; Endemic Diseases ; Female ; Hematopoietic Stem Cell Transplantation ; Hepatitis B virus - genetics ; Hepatitis B virus - isolation & purification ; Hepatitis B, Chronic - epidemiology ; Hepatitis B, Chronic - prevention & control ; Hong Kong - epidemiology ; Human viral diseases ; Humans ; Infectious diseases ; Male ; Medical sciences ; Middle Aged ; Occult HBV ; Predictive Value of Tests ; Prevalence ; Prevalence of occult HBV ; Retrospective Studies ; Viral diseases ; Viral diseases of the digestive system ; Viral hepatitis</subject><ispartof>Journal of hepatology, 2005-06, Vol.42 (6), p.813-819</ispartof><rights>2005 European Association for the Study of the Liver</rights><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c450t-328e82a0ddf103b4e7f28447876377e770deb439a229529ab9fe29372a4577983</citedby><cites>FETCH-LOGICAL-c450t-328e82a0ddf103b4e7f28447876377e770deb439a229529ab9fe29372a4577983</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jhep.2005.01.018$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16807819$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15885351$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hui, Chee-kin</creatorcontrib><creatorcontrib>Sun, Jian</creatorcontrib><creatorcontrib>Au, Wing-yan</creatorcontrib><creatorcontrib>Lie, Albert K.W.</creatorcontrib><creatorcontrib>Yueng, Yui-hung</creatorcontrib><creatorcontrib>Zhang, Hai-ying</creatorcontrib><creatorcontrib>Lee, Nikki P.</creatorcontrib><creatorcontrib>Hou, Jin-ling</creatorcontrib><creatorcontrib>Liang, Raymond</creatorcontrib><creatorcontrib>Lau, George K.K.</creatorcontrib><title>Occult hepatitis B virus infection in hematopoietic stem cell donors in a hepatitis B virus endemic area</title><title>Journal of hepatology</title><addtitle>J Hepatol</addtitle><description>The acquisition of hepatitis B virus (HBV) infection following organ transplantation from donors with occult HBV infection is an important cause of morbidity and mortality. The aim of this study is to determine the prevalence of occult HBV in allogeneic hematopoietic stem cell (HSC) transplantation donors.
We performed a retrospective study on 124 consecutive hepatitis B surface antigen negative HSC donors. Their serum samples were analyzed by PCR for the pre-S/S, pre-core/core and X regions of the virus. Samples reactive by at least two PCR assays were considered HBV-DNA positive.
Nineteen of the 124 HSC donors (15.3%) had occult HBV infection. Sixteen of these 19 donors with occult HBV infection (84.2%) tested positive for hepatitis B core antibody while 78 of 105 subjects (74.3%) without occult HBV infection were also positive (
P=0.56). Fourteen of the 19 donors (73.7%) with occult HBV infection tested positive for hepatitis B surface antibody while 67 of the 105 subjects without occult HBV infection were also positive (
P=0.45).
The prevalence of occult HBV infection among HSC donors in Hong Kong is high. Anti-HBc and anti-HBs status had no significant correlation with the presence of occult HBV infection.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Blood Donors - statistics & numerical data</subject><subject>Carrier State - epidemiology</subject><subject>DNA, Viral - blood</subject><subject>Endemic Diseases</subject><subject>Female</subject><subject>Hematopoietic Stem Cell Transplantation</subject><subject>Hepatitis B virus - genetics</subject><subject>Hepatitis B virus - isolation & purification</subject><subject>Hepatitis B, Chronic - epidemiology</subject><subject>Hepatitis B, Chronic - prevention & control</subject><subject>Hong Kong - epidemiology</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Occult HBV</subject><subject>Predictive Value of Tests</subject><subject>Prevalence</subject><subject>Prevalence of occult HBV</subject><subject>Retrospective Studies</subject><subject>Viral diseases</subject><subject>Viral diseases of the digestive system</subject><subject>Viral hepatitis</subject><issn>0168-8278</issn><issn>1600-0641</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LxDAQhoMoun78AQ_Si966TtK0ScGLLn6BsBc9h2w6ZbO0zZqkgv_elF3wIsJABvLMy8tDyCWFOQVa3W7mmzVu5wygnANNIw_IjFYAOVScHpJZgmQumZAn5DSEDQAUUPNjckJLKcuipDOyXhozdjFLQTraaEP2kH1ZP4bMDi2aaN2QtvTd6-i2zmK0JgsR-8xg12WNG5yf2Ez_EYFDg33itUd9To5a3QW82L9n5OPp8X3xkr8tn18X92-54SXEvGASJdPQNC2FYsVRtExyLqSoCiFQCGhwxYtaM1aXrNarukVWF4JpXgpRy-KM3Oxyt959jhii6m2YuuoB3RhUJSQtOYMEsh1ovAvBY6u23vbafysKavKrNmryqya_CmiaKf1qnz6uemx-T_ZCE3C9B3Qwumu9HowNv1wlIRWoE3e34zC5-LLoVTAWB4ON9Um7apz9r8cPGFeYlg</recordid><startdate>20050601</startdate><enddate>20050601</enddate><creator>Hui, Chee-kin</creator><creator>Sun, Jian</creator><creator>Au, Wing-yan</creator><creator>Lie, Albert K.W.</creator><creator>Yueng, Yui-hung</creator><creator>Zhang, Hai-ying</creator><creator>Lee, Nikki P.</creator><creator>Hou, Jin-ling</creator><creator>Liang, Raymond</creator><creator>Lau, George K.K.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20050601</creationdate><title>Occult hepatitis B virus infection in hematopoietic stem cell donors in a hepatitis B virus endemic area</title><author>Hui, Chee-kin ; Sun, Jian ; Au, Wing-yan ; Lie, Albert K.W. ; Yueng, Yui-hung ; Zhang, Hai-ying ; Lee, Nikki P. ; Hou, Jin-ling ; Liang, Raymond ; Lau, George K.K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c450t-328e82a0ddf103b4e7f28447876377e770deb439a229529ab9fe29372a4577983</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Blood Donors - statistics & numerical data</topic><topic>Carrier State - epidemiology</topic><topic>DNA, Viral - blood</topic><topic>Endemic Diseases</topic><topic>Female</topic><topic>Hematopoietic Stem Cell Transplantation</topic><topic>Hepatitis B virus - genetics</topic><topic>Hepatitis B virus - isolation & purification</topic><topic>Hepatitis B, Chronic - epidemiology</topic><topic>Hepatitis B, Chronic - prevention & control</topic><topic>Hong Kong - epidemiology</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Occult HBV</topic><topic>Predictive Value of Tests</topic><topic>Prevalence</topic><topic>Prevalence of occult HBV</topic><topic>Retrospective Studies</topic><topic>Viral diseases</topic><topic>Viral diseases of the digestive system</topic><topic>Viral hepatitis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hui, Chee-kin</creatorcontrib><creatorcontrib>Sun, Jian</creatorcontrib><creatorcontrib>Au, Wing-yan</creatorcontrib><creatorcontrib>Lie, Albert K.W.</creatorcontrib><creatorcontrib>Yueng, Yui-hung</creatorcontrib><creatorcontrib>Zhang, Hai-ying</creatorcontrib><creatorcontrib>Lee, Nikki P.</creatorcontrib><creatorcontrib>Hou, Jin-ling</creatorcontrib><creatorcontrib>Liang, Raymond</creatorcontrib><creatorcontrib>Lau, George K.K.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of hepatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hui, Chee-kin</au><au>Sun, Jian</au><au>Au, Wing-yan</au><au>Lie, Albert K.W.</au><au>Yueng, Yui-hung</au><au>Zhang, Hai-ying</au><au>Lee, Nikki P.</au><au>Hou, Jin-ling</au><au>Liang, Raymond</au><au>Lau, George K.K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Occult hepatitis B virus infection in hematopoietic stem cell donors in a hepatitis B virus endemic area</atitle><jtitle>Journal of hepatology</jtitle><addtitle>J Hepatol</addtitle><date>2005-06-01</date><risdate>2005</risdate><volume>42</volume><issue>6</issue><spage>813</spage><epage>819</epage><pages>813-819</pages><issn>0168-8278</issn><eissn>1600-0641</eissn><coden>JOHEEC</coden><abstract>The acquisition of hepatitis B virus (HBV) infection following organ transplantation from donors with occult HBV infection is an important cause of morbidity and mortality. The aim of this study is to determine the prevalence of occult HBV in allogeneic hematopoietic stem cell (HSC) transplantation donors.
We performed a retrospective study on 124 consecutive hepatitis B surface antigen negative HSC donors. Their serum samples were analyzed by PCR for the pre-S/S, pre-core/core and X regions of the virus. Samples reactive by at least two PCR assays were considered HBV-DNA positive.
Nineteen of the 124 HSC donors (15.3%) had occult HBV infection. Sixteen of these 19 donors with occult HBV infection (84.2%) tested positive for hepatitis B core antibody while 78 of 105 subjects (74.3%) without occult HBV infection were also positive (
P=0.56). Fourteen of the 19 donors (73.7%) with occult HBV infection tested positive for hepatitis B surface antibody while 67 of the 105 subjects without occult HBV infection were also positive (
P=0.45).
The prevalence of occult HBV infection among HSC donors in Hong Kong is high. Anti-HBc and anti-HBs status had no significant correlation with the presence of occult HBV infection.</abstract><cop>Oxford</cop><pub>Elsevier B.V</pub><pmid>15885351</pmid><doi>10.1016/j.jhep.2005.01.018</doi><tpages>7</tpages></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adult Biological and medical sciences Blood Donors - statistics & numerical data Carrier State - epidemiology DNA, Viral - blood Endemic Diseases Female Hematopoietic Stem Cell Transplantation Hepatitis B virus - genetics Hepatitis B virus - isolation & purification Hepatitis B, Chronic - epidemiology Hepatitis B, Chronic - prevention & control Hong Kong - epidemiology Human viral diseases Humans Infectious diseases Male Medical sciences Middle Aged Occult HBV Predictive Value of Tests Prevalence Prevalence of occult HBV Retrospective Studies Viral diseases Viral diseases of the digestive system Viral hepatitis |
| title | Occult hepatitis B virus infection in hematopoietic stem cell donors in a hepatitis B virus endemic area |
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