Marked Intraindividual Variability in Antiretroviral Concentrations May Limit the Utility of Therapeutic Drug Monitoring

Background. Effective therapeutic drug monitoring for antiretrovirals requires a better understanding of intraindividual variability in pharmacokinetics. Methods. We determined concentrations of human immunodeficiency virus (HIV) protease and nonnucleoside reverse-transcriptase inhibitors for 10 pat...

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Veröffentlicht in:	Clinical infectious diseases 2006-04, Vol.42 (8), p.1189-1196
Hauptverfasser:	Nettles, Richard E., Kieffer, Tara L., Parsons, Teresa, Johnson, James, Cofrancesco, Joseph, Gallant, Joel E., Carson, Kathryn A., Siliciano, Robert F., Flexner, Charles
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired Immunodeficiency Syndrome - blood Acquired Immunodeficiency Syndrome - drug therapy Adult Antiretroviral drugs Antiretroviral Therapy, Highly Active Antiretrovirals Antivirals Chromatography Clinical outcomes Dosage Drug monitoring Drug therapy Highly active antiretroviral therapy HIV HIV - isolation & purification HIV Infections - blood HIV Infections - drug therapy HIV Protease Inhibitors - blood HIV Protease Inhibitors - pharmacokinetics HIV Protease Inhibitors - therapeutic use HIV/AIDS Human immunodeficiency virus Humans Infectious diseases Medications Methods Nervous system Patients Pharmacokinetics Protease inhibitors Reproducibility of Results Reverse transcriptase inhibitors Reverse Transcriptase Inhibitors - blood Reverse Transcriptase Inhibitors - pharmacokinetics Reverse Transcriptase Inhibitors - therapeutic use RNA, Viral - blood Standard deviation Virology
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