Paradoxical effects of short- and long-term interleukin-6 exposure on liver injury and repair

Interleukin-6 (IL-6) is an important mediator of liver regeneration and repair that is also elevated in chronic liver diseases, including fatty liver of obesity and cirrhosis. IL-6 has been reported both to delay and accelerate liver regeneration. We examined the effects on liver injury and regenera...

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Veröffentlicht in:	Hepatology (Baltimore, Md.) Md.), 2006-03, Vol.43 (3), p.474-484
Hauptverfasser:	XIAOLING JIN, ZIMMERS, Teresa A, PEREZ, Eduardo A, PIERCE, Robert H, ZONGXIU ZHANG, KONIARIS, Leonidas G
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - drug effects Apoptosis - physiology bcl-Associated Death Protein bcl-X Protein Biological and medical sciences Caspase 9 Caspases CHO Cells Cricetinae Cricetulus fas Receptor Female Gastroenterology. Liver. Pancreas. Abdomen Hepatectomy - adverse effects Interleukin-6 - administration & dosage Interleukin-6 - pharmacology Liver - drug effects Liver - pathology Liver - physiology Liver Regeneration - drug effects Medical sciences Mice Mice, Inbred C57BL Mice, Nude Mitochondria, Liver Recombinant Proteins Wound Healing - drug effects
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