$Antagonist of fractalkine (CX3CL1) delays the initiation and ameliorates the progression of lupus nephritis in MRL/lpr mice$

Antagonist of fractalkine (CX3CL1) delays the initiation and ameliorates the progression of lupus nephritis in MRL/lpr mice

Objective Lupus nephritis is characterized by immune complex deposition and inflammatory cell infiltration into the renal glomeruli. Local generation of chemokines and the presence of chemokine receptors on the infiltrating cells may be involved in this process. Fractalkine (Fkn)/CX3CL1 and its rece...

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Veröffentlicht in:	Arthritis and rheumatism 2005-05, Vol.52 (5), p.1522-1533
Hauptverfasser:	Inoue, Atsushi, Hasegawa, Hitoshi, Kohno, Masashi, Ito, Mitsuko R., Terada, Miho, Imai, Toshio, Yoshie, Osamu, Nose, Masato, Fujita, Shigeru
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Chemokine CX3CL1 Chemokines, CX3C - antagonists & inhibitors Chemokines, CX3C - biosynthesis Dermatology Disease Progression Kidney - metabolism Lupus Nephritis - prevention & control Medical sciences Membrane Proteins - antagonists & inhibitors Membrane Proteins - biosynthesis Mice Mice, Inbred MRL lpr Skin involvement in other diseases. Miscellaneous. General aspects Time Factors
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