$Evidence that prostate gonadotropin-releasing hormone receptors mediate an anti-tumourigenic response to analogue therapy in hormone refractory prostate cancer$

Evidence that prostate gonadotropin-releasing hormone receptors mediate an anti-tumourigenic response to analogue therapy in hormone refractory prostate cancer

Gonadotropin‐releasing hormone analogue (GnRHa) therapy is an established method of androgen withdrawal in the treatment of prostate cancer. The present study investigated if the expression of prostate GnRH receptors (GnRHRs) might influence the response to GnRHa. GnRHR protein expression was first...

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Veröffentlicht in:	The Journal of pathology 2005-06, Vol.206 (2), p.205-213
Hauptverfasser:	Gnanapragasam, VJ, Darby, S, Khan, MM, Lock, WG, Robson, CN, Leung, HY
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents, Hormonal - therapeutic use Biological and medical sciences Cell Proliferation Dose-Response Relationship, Drug Gonadotropin-Releasing Hormone - agonists Gonadotropin-Releasing Hormone - therapeutic use gonadotropin-releasing hormone analogue gonadotropin-releasing hormone receptor hormone refractory Humans Investigative techniques, diagnostic techniques (general aspects) Male Medical sciences Neoplasm Invasiveness Neoplasm Proteins - metabolism Neoplasms, Hormone-Dependent - drug therapy Neoplasms, Hormone-Dependent - metabolism Neoplasms, Hormone-Dependent - pathology Nephrology. Urinary tract diseases Orchiectomy Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques prostate cancer Prostatic Neoplasms - metabolism Prostatic Neoplasms - pathology Prostatic Neoplasms - therapy Receptors, LHRH - metabolism Receptors, LHRH - physiology Survival Analysis Treatment Failure Tumor Cells, Cultured Tumor Stem Cell Assay Tumors of the urinary system Urinary tract. Prostate gland
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