Higher Levels of Basal Serial CSF Cortisol in Combat Veterans With Posttraumatic Stress Disorder
OBJECTIVE: Results of basal peripheral cortisol measures in posttraumatic stress disorder (PTSD) have been variable. The authors' goal was to measure CSF cortisol concentrations, which more accurately reflect brain glucocorticoid exposure, in subjects with or without PTSD. METHOD: CSF was withd...
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| Veröffentlicht in: | The American journal of psychiatry 2005-05, Vol.162 (5), p.992-994 |
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| container_title | The American journal of psychiatry |
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| creator | Baker, Dewleen G. Ekhator, Nosa N. Kasckow, John W. Dashevsky, Boris Horn, Paul S. Bednarik, Ludmila Geracioti, Thomas D. |
| description | OBJECTIVE: Results of basal peripheral cortisol measures in posttraumatic stress disorder (PTSD) have been variable. The authors' goal was to measure CSF cortisol concentrations, which more accurately reflect brain glucocorticoid exposure, in subjects with or without PTSD. METHOD: CSF was withdrawn from a subarachnoid catheter and plasma from a venous catheter, both indwelling, over a 6-hour interval to determine hourly plasma ACTH and cortisol concentrations and hourly CSF cortisol levels in eight well-characterized combat veterans with PTSD and eight matched healthy volunteers. RESULTS: Mean CSF cortisol concentrations were significantly higher in the subjects with PTSD (3.18 ng ml, SD=0.33) than in the normal volunteers (2.33 ng ml, SD=0.50), largely due to higher CSF cortisol concentration nadirs. No group differences were observed in either plasma ACTH or peripheral (plasma or urinary free) cortisol. CSF corticotropin-releasing hormone and CSF cortisol concentrations were positively and significantly correlated. CONCLUSIONS: Despite normal peripheral cortisol indexes in the veterans with PTSD, their CNS exposure to cortisol was greater than that of normal comparison subjects. |
| doi_str_mv | 10.1176/appi.ajp.162.5.992 |
| format | Article |
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The authors' goal was to measure CSF cortisol concentrations, which more accurately reflect brain glucocorticoid exposure, in subjects with or without PTSD. METHOD: CSF was withdrawn from a subarachnoid catheter and plasma from a venous catheter, both indwelling, over a 6-hour interval to determine hourly plasma ACTH and cortisol concentrations and hourly CSF cortisol levels in eight well-characterized combat veterans with PTSD and eight matched healthy volunteers. RESULTS: Mean CSF cortisol concentrations were significantly higher in the subjects with PTSD (3.18 ng ml, SD=0.33) than in the normal volunteers (2.33 ng ml, SD=0.50), largely due to higher CSF cortisol concentration nadirs. No group differences were observed in either plasma ACTH or peripheral (plasma or urinary free) cortisol. CSF corticotropin-releasing hormone and CSF cortisol concentrations were positively and significantly correlated. CONCLUSIONS: Despite normal peripheral cortisol indexes in the veterans with PTSD, their CNS exposure to cortisol was greater than that of normal comparison subjects.</description><identifier>ISSN: 0002-953X</identifier><identifier>EISSN: 1535-7228</identifier><identifier>DOI: 10.1176/appi.ajp.162.5.992</identifier><identifier>PMID: 15863803</identifier><identifier>CODEN: AJPSAO</identifier><language>eng</language><publisher>Washington, DC: American Psychiatric Publishing</publisher><subject>Adrenocorticotropic Hormone - blood ; Adrenocorticotropic Hormone - cerebrospinal fluid ; Adult ; Adult and adolescent clinical studies ; Anxiety disorders. Neuroses ; Biological and medical sciences ; Brain ; Catheterization, Peripheral ; Catheters, Indwelling ; Circadian Rhythm - physiology ; Clinical trials ; Combat Disorders - blood ; Combat Disorders - cerebrospinal fluid ; Combat Disorders - diagnosis ; Corticotropin-Releasing Hormone - blood ; Corticotropin-Releasing Hormone - cerebrospinal fluid ; Hormones ; Humans ; Hydrocortisone - blood ; Hydrocortisone - cerebrospinal fluid ; Male ; Medical sciences ; Post traumatic stress disorder ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Spinal Puncture ; Stress Disorders, Post-Traumatic - blood ; Stress Disorders, Post-Traumatic - cerebrospinal fluid ; Stress Disorders, Post-Traumatic - diagnosis ; Subarachnoid Space ; Veterans ; Veterans - statistics & numerical data</subject><ispartof>The American journal of psychiatry, 2005-05, Vol.162 (5), p.992-994</ispartof><rights>2005 INIST-CNRS</rights><rights>Copyright American Psychiatric Association May 2005</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a460t-d30196b168853a18dc7528c14083cbc46dffa7ae9f04a5e85af14754c41a0de53</citedby><cites>FETCH-LOGICAL-a460t-d30196b168853a18dc7528c14083cbc46dffa7ae9f04a5e85af14754c41a0de53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://psychiatryonline.org/doi/epdf/10.1176/appi.ajp.162.5.992$$EPDF$$P50$$Gappi$$H</linktopdf><linktohtml>$$Uhttps://psychiatryonline.org/doi/full/10.1176/appi.ajp.162.5.992$$EHTML$$P50$$Gappi$$H</linktohtml><link.rule.ids>314,780,784,2853,21625,21626,21627,27923,27924,77565,77570</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16738510$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15863803$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Baker, Dewleen G.</creatorcontrib><creatorcontrib>Ekhator, Nosa N.</creatorcontrib><creatorcontrib>Kasckow, John W.</creatorcontrib><creatorcontrib>Dashevsky, Boris</creatorcontrib><creatorcontrib>Horn, Paul S.</creatorcontrib><creatorcontrib>Bednarik, Ludmila</creatorcontrib><creatorcontrib>Geracioti, Thomas D.</creatorcontrib><title>Higher Levels of Basal Serial CSF Cortisol in Combat Veterans With Posttraumatic Stress Disorder</title><title>The American journal of psychiatry</title><addtitle>Am J Psychiatry</addtitle><description>OBJECTIVE: Results of basal peripheral cortisol measures in posttraumatic stress disorder (PTSD) have been variable. The authors' goal was to measure CSF cortisol concentrations, which more accurately reflect brain glucocorticoid exposure, in subjects with or without PTSD. METHOD: CSF was withdrawn from a subarachnoid catheter and plasma from a venous catheter, both indwelling, over a 6-hour interval to determine hourly plasma ACTH and cortisol concentrations and hourly CSF cortisol levels in eight well-characterized combat veterans with PTSD and eight matched healthy volunteers. RESULTS: Mean CSF cortisol concentrations were significantly higher in the subjects with PTSD (3.18 ng ml, SD=0.33) than in the normal volunteers (2.33 ng ml, SD=0.50), largely due to higher CSF cortisol concentration nadirs. No group differences were observed in either plasma ACTH or peripheral (plasma or urinary free) cortisol. CSF corticotropin-releasing hormone and CSF cortisol concentrations were positively and significantly correlated. CONCLUSIONS: Despite normal peripheral cortisol indexes in the veterans with PTSD, their CNS exposure to cortisol was greater than that of normal comparison subjects.</description><subject>Adrenocorticotropic Hormone - blood</subject><subject>Adrenocorticotropic Hormone - cerebrospinal fluid</subject><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>Anxiety disorders. 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Psychiatry</subject><subject>Spinal Puncture</subject><subject>Stress Disorders, Post-Traumatic - blood</subject><subject>Stress Disorders, Post-Traumatic - cerebrospinal fluid</subject><subject>Stress Disorders, Post-Traumatic - diagnosis</subject><subject>Subarachnoid Space</subject><subject>Veterans</subject><subject>Veterans - statistics & numerical data</subject><issn>0002-953X</issn><issn>1535-7228</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU2LFDEQhoMo7rj6BzxIEPTWvamk89FHHV1XGFAYv26xJp12M3RPt0la8N-bdQYXPOipEnjeqkoeQh4DqwG0usB5DjXu5xoUr2XdtvwOWYEUstKcm7tkxRjjVSvFlzPyIKV9uTKh-X1yBtIoYZhYka9X4du1j3Tjf_gh0amnLzHhQLc-hlLW20u6nmIOaRpoOJTzuMNMP_nsIx4S_RzyNX0_pZwjLiPm4Og2R58SfVUisfPxIbnX45D8o1M9Jx8vX39YX1Wbd2_erl9sKmwUy1UnGLRqB8oYKRBM57TkxkHDjHA716iu71Gjb3vWoPRGYg-Nlo1rAFnnpTgnz4995zh9X3zKdgzJ-WHAg5-WZJU2IKTh_wVBi4YbAQV8-he4n5Z4KI-wnLPGQGvaAvEj5OKUUvS9nWMYMf60wOyNJXtjyRZLtliy0hZLJfTk1HnZjb67jZy0FODZCcDkcOjLX7uQbjmlhZHACndx5H4P-bPeP0b_AsyaqyU</recordid><startdate>20050501</startdate><enddate>20050501</enddate><creator>Baker, Dewleen G.</creator><creator>Ekhator, Nosa N.</creator><creator>Kasckow, John W.</creator><creator>Dashevsky, Boris</creator><creator>Horn, Paul S.</creator><creator>Bednarik, Ludmila</creator><creator>Geracioti, Thomas D.</creator><general>American Psychiatric Publishing</general><general>American Psychiatric Association</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20050501</creationdate><title>Higher Levels of Basal Serial CSF Cortisol in Combat Veterans With Posttraumatic Stress Disorder</title><author>Baker, Dewleen G. ; Ekhator, Nosa N. ; Kasckow, John W. ; Dashevsky, Boris ; Horn, Paul S. ; Bednarik, Ludmila ; Geracioti, Thomas D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a460t-d30196b168853a18dc7528c14083cbc46dffa7ae9f04a5e85af14754c41a0de53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adrenocorticotropic Hormone - blood</topic><topic>Adrenocorticotropic Hormone - cerebrospinal fluid</topic><topic>Adult</topic><topic>Adult and adolescent clinical studies</topic><topic>Anxiety disorders. Neuroses</topic><topic>Biological and medical sciences</topic><topic>Brain</topic><topic>Catheterization, Peripheral</topic><topic>Catheters, Indwelling</topic><topic>Circadian Rhythm - physiology</topic><topic>Clinical trials</topic><topic>Combat Disorders - blood</topic><topic>Combat Disorders - cerebrospinal fluid</topic><topic>Combat Disorders - diagnosis</topic><topic>Corticotropin-Releasing Hormone - blood</topic><topic>Corticotropin-Releasing Hormone - cerebrospinal fluid</topic><topic>Hormones</topic><topic>Humans</topic><topic>Hydrocortisone - blood</topic><topic>Hydrocortisone - cerebrospinal fluid</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Post traumatic stress disorder</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Spinal Puncture</topic><topic>Stress Disorders, Post-Traumatic - blood</topic><topic>Stress Disorders, Post-Traumatic - cerebrospinal fluid</topic><topic>Stress Disorders, Post-Traumatic - diagnosis</topic><topic>Subarachnoid Space</topic><topic>Veterans</topic><topic>Veterans - statistics & numerical data</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Baker, Dewleen G.</creatorcontrib><creatorcontrib>Ekhator, Nosa N.</creatorcontrib><creatorcontrib>Kasckow, John W.</creatorcontrib><creatorcontrib>Dashevsky, Boris</creatorcontrib><creatorcontrib>Horn, Paul S.</creatorcontrib><creatorcontrib>Bednarik, Ludmila</creatorcontrib><creatorcontrib>Geracioti, Thomas D.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Baker, Dewleen G.</au><au>Ekhator, Nosa N.</au><au>Kasckow, John W.</au><au>Dashevsky, Boris</au><au>Horn, Paul S.</au><au>Bednarik, Ludmila</au><au>Geracioti, Thomas D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Higher Levels of Basal Serial CSF Cortisol in Combat Veterans With Posttraumatic Stress Disorder</atitle><jtitle>The American journal of psychiatry</jtitle><addtitle>Am J Psychiatry</addtitle><date>2005-05-01</date><risdate>2005</risdate><volume>162</volume><issue>5</issue><spage>992</spage><epage>994</epage><pages>992-994</pages><issn>0002-953X</issn><eissn>1535-7228</eissn><coden>AJPSAO</coden><abstract>OBJECTIVE: Results of basal peripheral cortisol measures in posttraumatic stress disorder (PTSD) have been variable. The authors' goal was to measure CSF cortisol concentrations, which more accurately reflect brain glucocorticoid exposure, in subjects with or without PTSD. METHOD: CSF was withdrawn from a subarachnoid catheter and plasma from a venous catheter, both indwelling, over a 6-hour interval to determine hourly plasma ACTH and cortisol concentrations and hourly CSF cortisol levels in eight well-characterized combat veterans with PTSD and eight matched healthy volunteers. RESULTS: Mean CSF cortisol concentrations were significantly higher in the subjects with PTSD (3.18 ng ml, SD=0.33) than in the normal volunteers (2.33 ng ml, SD=0.50), largely due to higher CSF cortisol concentration nadirs. No group differences were observed in either plasma ACTH or peripheral (plasma or urinary free) cortisol. CSF corticotropin-releasing hormone and CSF cortisol concentrations were positively and significantly correlated. CONCLUSIONS: Despite normal peripheral cortisol indexes in the veterans with PTSD, their CNS exposure to cortisol was greater than that of normal comparison subjects.</abstract><cop>Washington, DC</cop><pub>American Psychiatric Publishing</pub><pmid>15863803</pmid><doi>10.1176/appi.ajp.162.5.992</doi><tpages>3</tpages></addata></record> |
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| source | MEDLINE; American Psychiatric Publishing Journals (1997-Present); EZB-FREE-00999 freely available EZB journals |
| subjects | Adrenocorticotropic Hormone - blood Adrenocorticotropic Hormone - cerebrospinal fluid Adult Adult and adolescent clinical studies Anxiety disorders. Neuroses Biological and medical sciences Brain Catheterization, Peripheral Catheters, Indwelling Circadian Rhythm - physiology Clinical trials Combat Disorders - blood Combat Disorders - cerebrospinal fluid Combat Disorders - diagnosis Corticotropin-Releasing Hormone - blood Corticotropin-Releasing Hormone - cerebrospinal fluid Hormones Humans Hydrocortisone - blood Hydrocortisone - cerebrospinal fluid Male Medical sciences Post traumatic stress disorder Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Spinal Puncture Stress Disorders, Post-Traumatic - blood Stress Disorders, Post-Traumatic - cerebrospinal fluid Stress Disorders, Post-Traumatic - diagnosis Subarachnoid Space Veterans Veterans - statistics & numerical data |
| title | Higher Levels of Basal Serial CSF Cortisol in Combat Veterans With Posttraumatic Stress Disorder |
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