May glutathione S-transferase M1 positive genotype afford protection against primary open-angle glaucoma?
To find out whether the polymorphism at GSTM1, GSTT1 and GSTP1 loci is associated with increased susceptibility to glaucoma. We genotyped 153 primary open angle patients and 159 healthy controls. Genomic DNA from peripheral blood was examined using polymerase chain reaction and defined for the genet...
Gespeichert in:
| Veröffentlicht in: | Graefe's archive for clinical and experimental ophthalmology 2005-04, Vol.243 (4), p.327-333 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 333 |
|---|---|
| container_issue | 4 |
| container_start_page | 327 |
| container_title | Graefe's archive for clinical and experimental ophthalmology |
| container_volume | 243 |
| creator | Yildirim, Ozlem Ateş, Nurcan Aras Tamer, Lülüfer Oz, Ozay Yilmaz, Ayça Atik, Uĝur Camdeviren, Handan |
| description | To find out whether the polymorphism at GSTM1, GSTT1 and GSTP1 loci is associated with increased susceptibility to glaucoma.
We genotyped 153 primary open angle patients and 159 healthy controls. Genomic DNA from peripheral blood was examined using polymerase chain reaction and defined for the genetic polymorphisms of glutathione S-transferase.
The frequency of the GSTM1 null genotype individuals among the glaucoma patients was significanlty higher than in controls (54.9 vs 40.9%) with odds ratio of 1.64 (95% CI: 1.10-2.59). The frequency of the GSTT1 and GSTP1 in both groups were not statistically different.
The present study suggests that the GSTM1 null genotype may be a genetic risk factor for development of primary open angle glaucoma. Further associations studies in other polymorphic genes for xenobiotic-metabolizing enzymes are needed to elucidate the environmental-genetic interaction in the underlying cause of primary open angle glaucoma. |
| doi_str_mv | 10.1007/s00417-004-1013-9 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_67813287</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>982162001</sourcerecordid><originalsourceid>FETCH-LOGICAL-c326t-d67af9fb5997feab27ca7b86bf3af1b8f14980265f8b859e3244ab1e417e73433</originalsourceid><addsrcrecordid>eNpdkU1LxDAQhoMouq7-AC8SPHiL5qNt0pPI4hcoHlTYW5h2J2ul29QmFfbfm2UXBC8zMDzvMPO-hJwJfiU419eB80xolioTXChW7pGJyFTONJfzfTLhWgpmlJwfkeMQvngCVS4OyZHITZEVUk1I8wJrumzHCPGz8R3SNxYH6ILDAQLSF0F7H5rY_CBdYufjukcKzvlhQfvBR6xjUlFYQtOFmEbNCoY19T12DLplm1QtjLVfwc0JOXDQBjzd9Sn5uL97nz2y59eHp9ntM6uVLCJbFBpc6aq8LLVDqKSuQVemqJwCJyrjRFYaLovcmcrkJSqZZVAJTEagVplSU3K53Zvu-x4xRLtqQo1tCx36MdhCG6Gk0Qm8-Ad--XHo0m1WKq5Lk3OTILGF6sGHMKCzux-t4HYTgt2GYFO1mxBsmTTnu8VjtcLFn2LnuvoFA9mDkA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>230798508</pqid></control><display><type>article</type><title>May glutathione S-transferase M1 positive genotype afford protection against primary open-angle glaucoma?</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Yildirim, Ozlem ; Ateş, Nurcan Aras ; Tamer, Lülüfer ; Oz, Ozay ; Yilmaz, Ayça ; Atik, Uĝur ; Camdeviren, Handan</creator><creatorcontrib>Yildirim, Ozlem ; Ateş, Nurcan Aras ; Tamer, Lülüfer ; Oz, Ozay ; Yilmaz, Ayça ; Atik, Uĝur ; Camdeviren, Handan</creatorcontrib><description>To find out whether the polymorphism at GSTM1, GSTT1 and GSTP1 loci is associated with increased susceptibility to glaucoma.
We genotyped 153 primary open angle patients and 159 healthy controls. Genomic DNA from peripheral blood was examined using polymerase chain reaction and defined for the genetic polymorphisms of glutathione S-transferase.
The frequency of the GSTM1 null genotype individuals among the glaucoma patients was significanlty higher than in controls (54.9 vs 40.9%) with odds ratio of 1.64 (95% CI: 1.10-2.59). The frequency of the GSTT1 and GSTP1 in both groups were not statistically different.
The present study suggests that the GSTM1 null genotype may be a genetic risk factor for development of primary open angle glaucoma. Further associations studies in other polymorphic genes for xenobiotic-metabolizing enzymes are needed to elucidate the environmental-genetic interaction in the underlying cause of primary open angle glaucoma.</description><identifier>ISSN: 0721-832X</identifier><identifier>EISSN: 1435-702X</identifier><identifier>DOI: 10.1007/s00417-004-1013-9</identifier><identifier>PMID: 15864623</identifier><language>eng</language><publisher>Germany: Springer Nature B.V</publisher><subject>Adult ; Aged ; DNA Primers - chemistry ; Female ; Genotype ; Glaucoma ; Glaucoma, Open-Angle - enzymology ; Glaucoma, Open-Angle - genetics ; Glutathione S-Transferase pi ; Glutathione Transferase - genetics ; Humans ; Intraocular Pressure ; Isoenzymes - genetics ; Male ; Middle Aged ; Ophthalmology ; Polymerase Chain Reaction ; Polymorphism, Genetic ; Risk Factors</subject><ispartof>Graefe's archive for clinical and experimental ophthalmology, 2005-04, Vol.243 (4), p.327-333</ispartof><rights>Springer-Verlag 2005</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c326t-d67af9fb5997feab27ca7b86bf3af1b8f14980265f8b859e3244ab1e417e73433</citedby><cites>FETCH-LOGICAL-c326t-d67af9fb5997feab27ca7b86bf3af1b8f14980265f8b859e3244ab1e417e73433</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,27907,27908</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15864623$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yildirim, Ozlem</creatorcontrib><creatorcontrib>Ateş, Nurcan Aras</creatorcontrib><creatorcontrib>Tamer, Lülüfer</creatorcontrib><creatorcontrib>Oz, Ozay</creatorcontrib><creatorcontrib>Yilmaz, Ayça</creatorcontrib><creatorcontrib>Atik, Uĝur</creatorcontrib><creatorcontrib>Camdeviren, Handan</creatorcontrib><title>May glutathione S-transferase M1 positive genotype afford protection against primary open-angle glaucoma?</title><title>Graefe's archive for clinical and experimental ophthalmology</title><addtitle>Graefes Arch Clin Exp Ophthalmol</addtitle><description>To find out whether the polymorphism at GSTM1, GSTT1 and GSTP1 loci is associated with increased susceptibility to glaucoma.
We genotyped 153 primary open angle patients and 159 healthy controls. Genomic DNA from peripheral blood was examined using polymerase chain reaction and defined for the genetic polymorphisms of glutathione S-transferase.
The frequency of the GSTM1 null genotype individuals among the glaucoma patients was significanlty higher than in controls (54.9 vs 40.9%) with odds ratio of 1.64 (95% CI: 1.10-2.59). The frequency of the GSTT1 and GSTP1 in both groups were not statistically different.
The present study suggests that the GSTM1 null genotype may be a genetic risk factor for development of primary open angle glaucoma. Further associations studies in other polymorphic genes for xenobiotic-metabolizing enzymes are needed to elucidate the environmental-genetic interaction in the underlying cause of primary open angle glaucoma.</description><subject>Adult</subject><subject>Aged</subject><subject>DNA Primers - chemistry</subject><subject>Female</subject><subject>Genotype</subject><subject>Glaucoma</subject><subject>Glaucoma, Open-Angle - enzymology</subject><subject>Glaucoma, Open-Angle - genetics</subject><subject>Glutathione S-Transferase pi</subject><subject>Glutathione Transferase - genetics</subject><subject>Humans</subject><subject>Intraocular Pressure</subject><subject>Isoenzymes - genetics</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Ophthalmology</subject><subject>Polymerase Chain Reaction</subject><subject>Polymorphism, Genetic</subject><subject>Risk Factors</subject><issn>0721-832X</issn><issn>1435-702X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNpdkU1LxDAQhoMouq7-AC8SPHiL5qNt0pPI4hcoHlTYW5h2J2ul29QmFfbfm2UXBC8zMDzvMPO-hJwJfiU419eB80xolioTXChW7pGJyFTONJfzfTLhWgpmlJwfkeMQvngCVS4OyZHITZEVUk1I8wJrumzHCPGz8R3SNxYH6ILDAQLSF0F7H5rY_CBdYufjukcKzvlhQfvBR6xjUlFYQtOFmEbNCoY19T12DLplm1QtjLVfwc0JOXDQBjzd9Sn5uL97nz2y59eHp9ntM6uVLCJbFBpc6aq8LLVDqKSuQVemqJwCJyrjRFYaLovcmcrkJSqZZVAJTEagVplSU3K53Zvu-x4xRLtqQo1tCx36MdhCG6Gk0Qm8-Ad--XHo0m1WKq5Lk3OTILGF6sGHMKCzux-t4HYTgt2GYFO1mxBsmTTnu8VjtcLFn2LnuvoFA9mDkA</recordid><startdate>200504</startdate><enddate>200504</enddate><creator>Yildirim, Ozlem</creator><creator>Ateş, Nurcan Aras</creator><creator>Tamer, Lülüfer</creator><creator>Oz, Ozay</creator><creator>Yilmaz, Ayça</creator><creator>Atik, Uĝur</creator><creator>Camdeviren, Handan</creator><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>200504</creationdate><title>May glutathione S-transferase M1 positive genotype afford protection against primary open-angle glaucoma?</title><author>Yildirim, Ozlem ; Ateş, Nurcan Aras ; Tamer, Lülüfer ; Oz, Ozay ; Yilmaz, Ayça ; Atik, Uĝur ; Camdeviren, Handan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c326t-d67af9fb5997feab27ca7b86bf3af1b8f14980265f8b859e3244ab1e417e73433</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adult</topic><topic>Aged</topic><topic>DNA Primers - chemistry</topic><topic>Female</topic><topic>Genotype</topic><topic>Glaucoma</topic><topic>Glaucoma, Open-Angle - enzymology</topic><topic>Glaucoma, Open-Angle - genetics</topic><topic>Glutathione S-Transferase pi</topic><topic>Glutathione Transferase - genetics</topic><topic>Humans</topic><topic>Intraocular Pressure</topic><topic>Isoenzymes - genetics</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Ophthalmology</topic><topic>Polymerase Chain Reaction</topic><topic>Polymorphism, Genetic</topic><topic>Risk Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yildirim, Ozlem</creatorcontrib><creatorcontrib>Ateş, Nurcan Aras</creatorcontrib><creatorcontrib>Tamer, Lülüfer</creatorcontrib><creatorcontrib>Oz, Ozay</creatorcontrib><creatorcontrib>Yilmaz, Ayça</creatorcontrib><creatorcontrib>Atik, Uĝur</creatorcontrib><creatorcontrib>Camdeviren, Handan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Graefe's archive for clinical and experimental ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yildirim, Ozlem</au><au>Ateş, Nurcan Aras</au><au>Tamer, Lülüfer</au><au>Oz, Ozay</au><au>Yilmaz, Ayça</au><au>Atik, Uĝur</au><au>Camdeviren, Handan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>May glutathione S-transferase M1 positive genotype afford protection against primary open-angle glaucoma?</atitle><jtitle>Graefe's archive for clinical and experimental ophthalmology</jtitle><addtitle>Graefes Arch Clin Exp Ophthalmol</addtitle><date>2005-04</date><risdate>2005</risdate><volume>243</volume><issue>4</issue><spage>327</spage><epage>333</epage><pages>327-333</pages><issn>0721-832X</issn><eissn>1435-702X</eissn><abstract>To find out whether the polymorphism at GSTM1, GSTT1 and GSTP1 loci is associated with increased susceptibility to glaucoma.
We genotyped 153 primary open angle patients and 159 healthy controls. Genomic DNA from peripheral blood was examined using polymerase chain reaction and defined for the genetic polymorphisms of glutathione S-transferase.
The frequency of the GSTM1 null genotype individuals among the glaucoma patients was significanlty higher than in controls (54.9 vs 40.9%) with odds ratio of 1.64 (95% CI: 1.10-2.59). The frequency of the GSTT1 and GSTP1 in both groups were not statistically different.
The present study suggests that the GSTM1 null genotype may be a genetic risk factor for development of primary open angle glaucoma. Further associations studies in other polymorphic genes for xenobiotic-metabolizing enzymes are needed to elucidate the environmental-genetic interaction in the underlying cause of primary open angle glaucoma.</abstract><cop>Germany</cop><pub>Springer Nature B.V</pub><pmid>15864623</pmid><doi>10.1007/s00417-004-1013-9</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0721-832X |
| ispartof | Graefe's archive for clinical and experimental ophthalmology, 2005-04, Vol.243 (4), p.327-333 |
| issn | 0721-832X 1435-702X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_67813287 |
| source | MEDLINE; SpringerLink Journals |
| subjects | Adult Aged DNA Primers - chemistry Female Genotype Glaucoma Glaucoma, Open-Angle - enzymology Glaucoma, Open-Angle - genetics Glutathione S-Transferase pi Glutathione Transferase - genetics Humans Intraocular Pressure Isoenzymes - genetics Male Middle Aged Ophthalmology Polymerase Chain Reaction Polymorphism, Genetic Risk Factors |
| title | May glutathione S-transferase M1 positive genotype afford protection against primary open-angle glaucoma? |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-17T03%3A49%3A20IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=May%20glutathione%20S-transferase%20M1%20positive%20genotype%20afford%20protection%20against%20primary%20open-angle%20glaucoma?&rft.jtitle=Graefe's%20archive%20for%20clinical%20and%20experimental%20ophthalmology&rft.au=Yildirim,%20Ozlem&rft.date=2005-04&rft.volume=243&rft.issue=4&rft.spage=327&rft.epage=333&rft.pages=327-333&rft.issn=0721-832X&rft.eissn=1435-702X&rft_id=info:doi/10.1007/s00417-004-1013-9&rft_dat=%3Cproquest_cross%3E982162001%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=230798508&rft_id=info:pmid/15864623&rfr_iscdi=true |