N-Benzylbenzamides: A new class of potent tyrosinase inhibitors

A series of potent inhibitors of tyrosinase and their structure–activity relationships are described. N-Benzylbenzamide derivatives (1–21) with hydroxyl(s) were synthesized and tested for their tyrosinase inhibitory activity. With this series, compound 15 provided a potent tyrosinase inhibition: it...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2006-05, Vol.16 (10), p.2682-2684
Hauptverfasser:	Cho, Sung Jin, Roh, Jung Seop, Sun, Won Suck, Kim, Sung Han, Park, Ki Duk
Format:	Artikel
Sprache:	eng
Schlagworte:	4-Substituted resorcinol Benzamides - pharmacology Biological and medical sciences Catalysis Enzyme Inhibitors - pharmacology Levodopa - antagonists & inhibitors Levodopa - chemistry Medical sciences Miscellaneous Monophenol Monooxygenase - antagonists & inhibitors N-Benzylbenzamides Oxidation-Reduction Pharmacology. Drug treatments SAR Tyrosinase inhibitor
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