JNK mediates hepatic ischemia reperfusion injury

Hepatic ischemia followed by reperfusion (I/R) is a major clinical problem during transplantation, liver resection for tumor, and circulatory shock, producing apoptosis and necrosis. Although several intracellular signal molecules are induced following I/R including NF-κB and c-Jun N terminal kinase...

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Veröffentlicht in:	Journal of hepatology 2005-06, Vol.42 (6), p.850-859
Hauptverfasser:	Uehara, Tetsuya, Bennett, Brydon, Sakata, Steve T., Satoh, Yoshitaka, Bilter, Graham K., Westwick, John K., Brenner, David A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Biological and medical sciences c-Jun Caspase 3 Caspases - metabolism Cytochromes c - metabolism Cytoplasm - metabolism Disease Models, Animal Enzyme Inhibitors - pharmacology Gastroenterology. Liver. Pancreas. Abdomen JNK Mitogen-Activated Protein Kinases - antagonists & inhibitors JNK Mitogen-Activated Protein Kinases - metabolism Lipid Peroxidation - drug effects Liver Liver - enzymology Liver - pathology Liver, biliary tract, pancreas, portal circulation, spleen Male Medical sciences Mitochondria - metabolism Necrosis Rats Rats, Wistar Reperfusion Injury - drug therapy Reperfusion Injury - metabolism Reperfusion Injury - mortality Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the digestive system Tumor necrosis factor α Tumor Necrosis Factor-alpha - metabolism
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