Biotin Deficiency in an Infant Fed with Amino Acid Formula
Biotin deficiency is rarely encountered in an infant on weaning from breast and formula feeding. It is characterized by alopecia and scaly, erythematous dermatitis distributed around the body orifices. We report a 5‐month‐old Japanese infant with typical skin lesions who had been diagnosed as a neon...
Gespeichert in:
| Veröffentlicht in: | Journal of dermatology 2005-04, Vol.32 (4), p.256-261 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 261 |
|---|---|
| container_issue | 4 |
| container_start_page | 256 |
| container_title | Journal of dermatology |
| container_volume | 32 |
| creator | Fujimoto, Wataru Inaoki, Makoto Fukui, Toru Inoue, Yoshito Kuhara, Tomiko |
| description | Biotin deficiency is rarely encountered in an infant on weaning from breast and formula feeding. It is characterized by alopecia and scaly, erythematous dermatitis distributed around the body orifices. We report a 5‐month‐old Japanese infant with typical skin lesions who had been diagnosed as a neonate with dyspepsia and fed only an amino acid formula. Serum and urine levels of biotin were below the normal range, but zinc and biotinidase were within normal range. Urinary excretion of 3‐methylcrotonylglycine, 3‐hydroxyisovaleric acid, and methylcitric acid was significantly elevated. Daily oral supplementation with 1 mg of biotin resulted in dramatic improvement of the periorificial dermatitis and hair growth together with a complete disappearance of the organic aciduria. Our case shows that the characteristic skin manifestations are the most important clue to the diagnosis of biotin deficiency and demonstrated that urinary excretion of biotin and organic aciduria, rather than the serum concentration of biotin, are the sensitive indicators for evaluating the patient's status of biotin deficiency. |
| doi_str_mv | 10.1111/j.1346-8138.2005.tb00758.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_67812714</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>67812714</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4278-bcf43f991660b22640da3fce211c0b870e825b631d63ee357870c833879f6fe33</originalsourceid><addsrcrecordid>eNqVkMlOwzAQhi0EoqXwCsjiwC3BS2I7PVG6QFElLnC2HMcWrrKUOFHbtyehEZyZy2z_PyN9ANxhFOIuHrYhphELBKYiJAjFYZMixGMRHs7A-Hd1DsaIijggEeIjcOX9FiGSxBhdghGOBaMiYmMwfXJV40q4MNZpZ0p9hF2nSrgurSobuDIZ3LvmE84KV1Zwpl0GV1VdtLm6BhdW5d7cDHkCPlbL9_lLsHl7Xs9nm0BHhIsg1TaiNkkwYyglhEUoU9RqQzDWKBUcGUHilFGcMWoMjXk30oJSwRPLrKF0Au5Pd3d19dUa38jCeW3yXJWmar1kXGDCcdQJpyehrivva2PlrnaFqo8SI9mTk1vZ45E9HtmTkwM5eejMt8OXNi1M9mcdUHWCx5Ng73Jz_Mdp-bpY_pT0GxHTe_M</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>67812714</pqid></control><display><type>article</type><title>Biotin Deficiency in an Infant Fed with Amino Acid Formula</title><source>MEDLINE</source><source>Wiley Blackwell Single Titles</source><creator>Fujimoto, Wataru ; Inaoki, Makoto ; Fukui, Toru ; Inoue, Yoshito ; Kuhara, Tomiko</creator><creatorcontrib>Fujimoto, Wataru ; Inaoki, Makoto ; Fukui, Toru ; Inoue, Yoshito ; Kuhara, Tomiko</creatorcontrib><description>Biotin deficiency is rarely encountered in an infant on weaning from breast and formula feeding. It is characterized by alopecia and scaly, erythematous dermatitis distributed around the body orifices. We report a 5‐month‐old Japanese infant with typical skin lesions who had been diagnosed as a neonate with dyspepsia and fed only an amino acid formula. Serum and urine levels of biotin were below the normal range, but zinc and biotinidase were within normal range. Urinary excretion of 3‐methylcrotonylglycine, 3‐hydroxyisovaleric acid, and methylcitric acid was significantly elevated. Daily oral supplementation with 1 mg of biotin resulted in dramatic improvement of the periorificial dermatitis and hair growth together with a complete disappearance of the organic aciduria. Our case shows that the characteristic skin manifestations are the most important clue to the diagnosis of biotin deficiency and demonstrated that urinary excretion of biotin and organic aciduria, rather than the serum concentration of biotin, are the sensitive indicators for evaluating the patient's status of biotin deficiency.</description><identifier>ISSN: 0385-2407</identifier><identifier>EISSN: 1346-8138</identifier><identifier>DOI: 10.1111/j.1346-8138.2005.tb00758.x</identifier><identifier>PMID: 15863846</identifier><language>eng</language><publisher>England</publisher><subject>alopecia ; biotin ; Biotin - administration & dosage ; Biotin - blood ; Biotin - deficiency ; Biotin - urine ; Deficiency Diseases - diagnosis ; Deficiency Diseases - drug therapy ; Deficiency Diseases - pathology ; Dietary Supplements ; Erythema - diagnosis ; Erythema - drug therapy ; Erythema - pathology ; Facial Dermatoses - diagnosis ; Facial Dermatoses - drug therapy ; Facial Dermatoses - pathology ; formula ; Humans ; Infant ; Infant Formula ; Male ; organic aciduria ; periorificial dermatitis ; Peritoneum</subject><ispartof>Journal of dermatology, 2005-04, Vol.32 (4), p.256-261</ispartof><rights>2005 Japanese Dermatological Association</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4278-bcf43f991660b22640da3fce211c0b870e825b631d63ee357870c833879f6fe33</citedby><cites>FETCH-LOGICAL-c4278-bcf43f991660b22640da3fce211c0b870e825b631d63ee357870c833879f6fe33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1346-8138.2005.tb00758.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1346-8138.2005.tb00758.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15863846$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fujimoto, Wataru</creatorcontrib><creatorcontrib>Inaoki, Makoto</creatorcontrib><creatorcontrib>Fukui, Toru</creatorcontrib><creatorcontrib>Inoue, Yoshito</creatorcontrib><creatorcontrib>Kuhara, Tomiko</creatorcontrib><title>Biotin Deficiency in an Infant Fed with Amino Acid Formula</title><title>Journal of dermatology</title><addtitle>J Dermatol</addtitle><description>Biotin deficiency is rarely encountered in an infant on weaning from breast and formula feeding. It is characterized by alopecia and scaly, erythematous dermatitis distributed around the body orifices. We report a 5‐month‐old Japanese infant with typical skin lesions who had been diagnosed as a neonate with dyspepsia and fed only an amino acid formula. Serum and urine levels of biotin were below the normal range, but zinc and biotinidase were within normal range. Urinary excretion of 3‐methylcrotonylglycine, 3‐hydroxyisovaleric acid, and methylcitric acid was significantly elevated. Daily oral supplementation with 1 mg of biotin resulted in dramatic improvement of the periorificial dermatitis and hair growth together with a complete disappearance of the organic aciduria. Our case shows that the characteristic skin manifestations are the most important clue to the diagnosis of biotin deficiency and demonstrated that urinary excretion of biotin and organic aciduria, rather than the serum concentration of biotin, are the sensitive indicators for evaluating the patient's status of biotin deficiency.</description><subject>alopecia</subject><subject>biotin</subject><subject>Biotin - administration & dosage</subject><subject>Biotin - blood</subject><subject>Biotin - deficiency</subject><subject>Biotin - urine</subject><subject>Deficiency Diseases - diagnosis</subject><subject>Deficiency Diseases - drug therapy</subject><subject>Deficiency Diseases - pathology</subject><subject>Dietary Supplements</subject><subject>Erythema - diagnosis</subject><subject>Erythema - drug therapy</subject><subject>Erythema - pathology</subject><subject>Facial Dermatoses - diagnosis</subject><subject>Facial Dermatoses - drug therapy</subject><subject>Facial Dermatoses - pathology</subject><subject>formula</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant Formula</subject><subject>Male</subject><subject>organic aciduria</subject><subject>periorificial dermatitis</subject><subject>Peritoneum</subject><issn>0385-2407</issn><issn>1346-8138</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkMlOwzAQhi0EoqXwCsjiwC3BS2I7PVG6QFElLnC2HMcWrrKUOFHbtyehEZyZy2z_PyN9ANxhFOIuHrYhphELBKYiJAjFYZMixGMRHs7A-Hd1DsaIijggEeIjcOX9FiGSxBhdghGOBaMiYmMwfXJV40q4MNZpZ0p9hF2nSrgurSobuDIZ3LvmE84KV1Zwpl0GV1VdtLm6BhdW5d7cDHkCPlbL9_lLsHl7Xs9nm0BHhIsg1TaiNkkwYyglhEUoU9RqQzDWKBUcGUHilFGcMWoMjXk30oJSwRPLrKF0Au5Pd3d19dUa38jCeW3yXJWmar1kXGDCcdQJpyehrivva2PlrnaFqo8SI9mTk1vZ45E9HtmTkwM5eejMt8OXNi1M9mcdUHWCx5Ng73Jz_Mdp-bpY_pT0GxHTe_M</recordid><startdate>200504</startdate><enddate>200504</enddate><creator>Fujimoto, Wataru</creator><creator>Inaoki, Makoto</creator><creator>Fukui, Toru</creator><creator>Inoue, Yoshito</creator><creator>Kuhara, Tomiko</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200504</creationdate><title>Biotin Deficiency in an Infant Fed with Amino Acid Formula</title><author>Fujimoto, Wataru ; Inaoki, Makoto ; Fukui, Toru ; Inoue, Yoshito ; Kuhara, Tomiko</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4278-bcf43f991660b22640da3fce211c0b870e825b631d63ee357870c833879f6fe33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>alopecia</topic><topic>biotin</topic><topic>Biotin - administration & dosage</topic><topic>Biotin - blood</topic><topic>Biotin - deficiency</topic><topic>Biotin - urine</topic><topic>Deficiency Diseases - diagnosis</topic><topic>Deficiency Diseases - drug therapy</topic><topic>Deficiency Diseases - pathology</topic><topic>Dietary Supplements</topic><topic>Erythema - diagnosis</topic><topic>Erythema - drug therapy</topic><topic>Erythema - pathology</topic><topic>Facial Dermatoses - diagnosis</topic><topic>Facial Dermatoses - drug therapy</topic><topic>Facial Dermatoses - pathology</topic><topic>formula</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant Formula</topic><topic>Male</topic><topic>organic aciduria</topic><topic>periorificial dermatitis</topic><topic>Peritoneum</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fujimoto, Wataru</creatorcontrib><creatorcontrib>Inaoki, Makoto</creatorcontrib><creatorcontrib>Fukui, Toru</creatorcontrib><creatorcontrib>Inoue, Yoshito</creatorcontrib><creatorcontrib>Kuhara, Tomiko</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fujimoto, Wataru</au><au>Inaoki, Makoto</au><au>Fukui, Toru</au><au>Inoue, Yoshito</au><au>Kuhara, Tomiko</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Biotin Deficiency in an Infant Fed with Amino Acid Formula</atitle><jtitle>Journal of dermatology</jtitle><addtitle>J Dermatol</addtitle><date>2005-04</date><risdate>2005</risdate><volume>32</volume><issue>4</issue><spage>256</spage><epage>261</epage><pages>256-261</pages><issn>0385-2407</issn><eissn>1346-8138</eissn><abstract>Biotin deficiency is rarely encountered in an infant on weaning from breast and formula feeding. It is characterized by alopecia and scaly, erythematous dermatitis distributed around the body orifices. We report a 5‐month‐old Japanese infant with typical skin lesions who had been diagnosed as a neonate with dyspepsia and fed only an amino acid formula. Serum and urine levels of biotin were below the normal range, but zinc and biotinidase were within normal range. Urinary excretion of 3‐methylcrotonylglycine, 3‐hydroxyisovaleric acid, and methylcitric acid was significantly elevated. Daily oral supplementation with 1 mg of biotin resulted in dramatic improvement of the periorificial dermatitis and hair growth together with a complete disappearance of the organic aciduria. Our case shows that the characteristic skin manifestations are the most important clue to the diagnosis of biotin deficiency and demonstrated that urinary excretion of biotin and organic aciduria, rather than the serum concentration of biotin, are the sensitive indicators for evaluating the patient's status of biotin deficiency.</abstract><cop>England</cop><pmid>15863846</pmid><doi>10.1111/j.1346-8138.2005.tb00758.x</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0385-2407 |
| ispartof | Journal of dermatology, 2005-04, Vol.32 (4), p.256-261 |
| issn | 0385-2407 1346-8138 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_67812714 |
| source | MEDLINE; Wiley Blackwell Single Titles |
| subjects | alopecia biotin Biotin - administration & dosage Biotin - blood Biotin - deficiency Biotin - urine Deficiency Diseases - diagnosis Deficiency Diseases - drug therapy Deficiency Diseases - pathology Dietary Supplements Erythema - diagnosis Erythema - drug therapy Erythema - pathology Facial Dermatoses - diagnosis Facial Dermatoses - drug therapy Facial Dermatoses - pathology formula Humans Infant Infant Formula Male organic aciduria periorificial dermatitis Peritoneum |
| title | Biotin Deficiency in an Infant Fed with Amino Acid Formula |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-03T17%3A59%3A56IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Biotin%20Deficiency%20in%20an%20Infant%20Fed%20with%20Amino%20Acid%20Formula&rft.jtitle=Journal%20of%20dermatology&rft.au=Fujimoto,%20Wataru&rft.date=2005-04&rft.volume=32&rft.issue=4&rft.spage=256&rft.epage=261&rft.pages=256-261&rft.issn=0385-2407&rft.eissn=1346-8138&rft_id=info:doi/10.1111/j.1346-8138.2005.tb00758.x&rft_dat=%3Cproquest_cross%3E67812714%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=67812714&rft_id=info:pmid/15863846&rfr_iscdi=true |