Propolis: Effect of different concentrations, extracts and intake period on seric biochemical variables
Propolis is a resinous substance produced by honeybees that possesses many biological activities, such as antitumor, antioxidant, antimicrobial, anti-inflammatory, and immunomodulatory, among others. The purpose of the present study was to investigate the biochemical profile of propolis-treated rats...
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| Veröffentlicht in: | Journal of ethnopharmacology 2006-04, Vol.105 (1), p.95-98 |
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| container_title | Journal of ethnopharmacology |
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| creator | Mani, F. Damasceno, H.C.R. Novelli, E.L.B. Martins, E.A.M. Sforcin, J.M. |
| description | Propolis is a resinous substance produced by honeybees that possesses many biological activities, such as antitumor, antioxidant, antimicrobial, anti-inflammatory, and immunomodulatory, among others. The purpose of the present study was to investigate the biochemical profile of propolis-treated rats to observe whether propolis might lead to side effects after administration. Three different treatments were analyzed: (1) rats were treated with different concentrations of propolis (1, 3 and 6
mg/kg/day) during 30 days; (2) rats were treated with 1
mg/kg/day of ethanolic or water extracts of propolis (EEP, WEP) during 30 days; (3) rats were treated with 1
mg/kg/day of ethanolic extract of propolis during 90 and 150 days. Our results demonstrated no alterations in the seric levels of cholesterol, HDL-cholesterol, total lipids, triglycerides and in the specific activity of aminotransferases (AST) and lactic dehydrogenase (LDH) of propolis-treated groups when compared to controls. On the basis of our findings, since propolis does not induce any significant change in seric parameters, it is claimed that long-term administration of propolis might not have any cardiac injury. |
| doi_str_mv | 10.1016/j.jep.2005.10.011 |
| format | Article |
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mg/kg/day) during 30 days; (2) rats were treated with 1
mg/kg/day of ethanolic or water extracts of propolis (EEP, WEP) during 30 days; (3) rats were treated with 1
mg/kg/day of ethanolic extract of propolis during 90 and 150 days. Our results demonstrated no alterations in the seric levels of cholesterol, HDL-cholesterol, total lipids, triglycerides and in the specific activity of aminotransferases (AST) and lactic dehydrogenase (LDH) of propolis-treated groups when compared to controls. On the basis of our findings, since propolis does not induce any significant change in seric parameters, it is claimed that long-term administration of propolis might not have any cardiac injury.</description><identifier>ISSN: 0378-8741</identifier><identifier>EISSN: 1872-7573</identifier><identifier>DOI: 10.1016/j.jep.2005.10.011</identifier><identifier>PMID: 16293383</identifier><identifier>CODEN: JOETD7</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Animals ; Biochemical variables ; Biological and medical sciences ; Cardiotoxicity ; Cholesterol, HDL - blood ; Cholesterol, LDL - blood ; Dose-Response Relationship, Drug ; Extracts ; General pharmacology ; Male ; Medical sciences ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; Propolis ; Rats ; Rats, Wistar</subject><ispartof>Journal of ethnopharmacology, 2006-04, Vol.105 (1), p.95-98</ispartof><rights>2005 Elsevier Ireland Ltd</rights><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c447t-a494d3e0a982de27d329758ec13bccc414df556e42721ba777b3710a2ccc14a73</citedby><cites>FETCH-LOGICAL-c447t-a494d3e0a982de27d329758ec13bccc414df556e42721ba777b3710a2ccc14a73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jep.2005.10.011$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17691767$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16293383$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mani, F.</creatorcontrib><creatorcontrib>Damasceno, H.C.R.</creatorcontrib><creatorcontrib>Novelli, E.L.B.</creatorcontrib><creatorcontrib>Martins, E.A.M.</creatorcontrib><creatorcontrib>Sforcin, J.M.</creatorcontrib><title>Propolis: Effect of different concentrations, extracts and intake period on seric biochemical variables</title><title>Journal of ethnopharmacology</title><addtitle>J Ethnopharmacol</addtitle><description>Propolis is a resinous substance produced by honeybees that possesses many biological activities, such as antitumor, antioxidant, antimicrobial, anti-inflammatory, and immunomodulatory, among others. The purpose of the present study was to investigate the biochemical profile of propolis-treated rats to observe whether propolis might lead to side effects after administration. Three different treatments were analyzed: (1) rats were treated with different concentrations of propolis (1, 3 and 6
mg/kg/day) during 30 days; (2) rats were treated with 1
mg/kg/day of ethanolic or water extracts of propolis (EEP, WEP) during 30 days; (3) rats were treated with 1
mg/kg/day of ethanolic extract of propolis during 90 and 150 days. Our results demonstrated no alterations in the seric levels of cholesterol, HDL-cholesterol, total lipids, triglycerides and in the specific activity of aminotransferases (AST) and lactic dehydrogenase (LDH) of propolis-treated groups when compared to controls. On the basis of our findings, since propolis does not induce any significant change in seric parameters, it is claimed that long-term administration of propolis might not have any cardiac injury.</description><subject>Animals</subject><subject>Biochemical variables</subject><subject>Biological and medical sciences</subject><subject>Cardiotoxicity</subject><subject>Cholesterol, HDL - blood</subject><subject>Cholesterol, LDL - blood</subject><subject>Dose-Response Relationship, Drug</subject><subject>Extracts</subject><subject>General pharmacology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>Propolis</subject><subject>Rats</subject><subject>Rats, Wistar</subject><issn>0378-8741</issn><issn>1872-7573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kcFu1DAQQC0EotvCB3CpfIFTs3hsJ5OUE6raglQJDnC2HHsC3mbj1M5W8Pf1alfqrQdrxvab0fiZsQ8g1iCg-bxZb2heSyHqsl8LgFdsBS3KCmtUr9lKKGyrFjWcsNOcN0IIBC3eshNoZKdUq1bsz88U5ziGfMmvh4HcwuPAfShpomnhLk6uxGSXEKd8welfyd2SuZ08D9Ni74nPlEL0PE48l8zxPkT3l7bB2ZE_2hRsP1J-x94Mdsz0_hjP2O-b619X36q7H7ffr77eVU5rXCqrO-0VCdu10pNEr2SHdUsOVO-c06D9UNcNaYkSeouIvUIQVpZL0BbVGft06Dun-LCjvJhtyI7G0U4Ud9k02ALUrSwgHECXYs6JBjOnsLXpvwFh9nbNxhS7Zm93f1TslprzY_NdvyX_XHHUWYCPR8Dm8vwh2cmF_Mxh05W1n_LLgaOi4jFQMtkFKqp9SOUPjI_hhTGeABZDmII</recordid><startdate>20060421</startdate><enddate>20060421</enddate><creator>Mani, F.</creator><creator>Damasceno, H.C.R.</creator><creator>Novelli, E.L.B.</creator><creator>Martins, E.A.M.</creator><creator>Sforcin, J.M.</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20060421</creationdate><title>Propolis: Effect of different concentrations, extracts and intake period on seric biochemical variables</title><author>Mani, F. ; Damasceno, H.C.R. ; Novelli, E.L.B. ; Martins, E.A.M. ; Sforcin, J.M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c447t-a494d3e0a982de27d329758ec13bccc414df556e42721ba777b3710a2ccc14a73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Animals</topic><topic>Biochemical variables</topic><topic>Biological and medical sciences</topic><topic>Cardiotoxicity</topic><topic>Cholesterol, HDL - blood</topic><topic>Cholesterol, LDL - blood</topic><topic>Dose-Response Relationship, Drug</topic><topic>Extracts</topic><topic>General pharmacology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>Propolis</topic><topic>Rats</topic><topic>Rats, Wistar</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mani, F.</creatorcontrib><creatorcontrib>Damasceno, H.C.R.</creatorcontrib><creatorcontrib>Novelli, E.L.B.</creatorcontrib><creatorcontrib>Martins, E.A.M.</creatorcontrib><creatorcontrib>Sforcin, J.M.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of ethnopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mani, F.</au><au>Damasceno, H.C.R.</au><au>Novelli, E.L.B.</au><au>Martins, E.A.M.</au><au>Sforcin, J.M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Propolis: Effect of different concentrations, extracts and intake period on seric biochemical variables</atitle><jtitle>Journal of ethnopharmacology</jtitle><addtitle>J Ethnopharmacol</addtitle><date>2006-04-21</date><risdate>2006</risdate><volume>105</volume><issue>1</issue><spage>95</spage><epage>98</epage><pages>95-98</pages><issn>0378-8741</issn><eissn>1872-7573</eissn><coden>JOETD7</coden><abstract>Propolis is a resinous substance produced by honeybees that possesses many biological activities, such as antitumor, antioxidant, antimicrobial, anti-inflammatory, and immunomodulatory, among others. The purpose of the present study was to investigate the biochemical profile of propolis-treated rats to observe whether propolis might lead to side effects after administration. Three different treatments were analyzed: (1) rats were treated with different concentrations of propolis (1, 3 and 6
mg/kg/day) during 30 days; (2) rats were treated with 1
mg/kg/day of ethanolic or water extracts of propolis (EEP, WEP) during 30 days; (3) rats were treated with 1
mg/kg/day of ethanolic extract of propolis during 90 and 150 days. Our results demonstrated no alterations in the seric levels of cholesterol, HDL-cholesterol, total lipids, triglycerides and in the specific activity of aminotransferases (AST) and lactic dehydrogenase (LDH) of propolis-treated groups when compared to controls. On the basis of our findings, since propolis does not induce any significant change in seric parameters, it is claimed that long-term administration of propolis might not have any cardiac injury.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>16293383</pmid><doi>10.1016/j.jep.2005.10.011</doi><tpages>4</tpages></addata></record> |
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| subjects | Animals Biochemical variables Biological and medical sciences Cardiotoxicity Cholesterol, HDL - blood Cholesterol, LDL - blood Dose-Response Relationship, Drug Extracts General pharmacology Male Medical sciences Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Propolis Rats Rats, Wistar |
| title | Propolis: Effect of different concentrations, extracts and intake period on seric biochemical variables |
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