Immune interaction between components of acellular pertussis-diphtheria-tetanus (DTaP) vaccine and Haemophilus influenzae b (Hib) conjugate vaccine in a rat model

We have previously shown that, consistent with clinical trial results, the immune response to a Haemophilus influenzae b (Hib) conjugate vaccine in a rat model was compromised and modulated when given combined with a DTaP 3 vaccine, as compared to both vaccines given separately. The present study ex...

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Veröffentlicht in:	Vaccine 2006-04, Vol.24 (17), p.3505-3512
Hauptverfasser:	Mawas, Fatme, Dickinson, Robert, Douglas-Bardsley, Alexandra, Xing, Dorothy K.L., Sesardic, Dorothea, Corbel, Michael J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acelluar pertussis antigens Adhesins, Bacterial - immunology Adjuvants, Immunologic - pharmacology Aluminum Compounds - pharmacology Aluminum Hydroxide - pharmacology Animals Applied microbiology B-Lymphocytes - immunology Bacterial Capsules Bacterial diseases Bacteriology Biological and medical sciences Bordetella pertussis Clostridium tetani Combination vaccine Corynebacterium diphtheriae Diphtheria Diphtheria-Tetanus-acellular Pertussis Vaccines - administration & dosage Diphtheria-Tetanus-acellular Pertussis Vaccines - immunology Ent and stomatologic bacterial diseases Female Fundamental and applied biological sciences. Psychology Haemophilus influenzae Haemophilus influenzae b Haemophilus Vaccines - administration & dosage Haemophilus Vaccines - immunology Human bacterial diseases Infectious diseases Interferon-gamma - biosynthesis Interleukin-4 - biosynthesis Medical sciences Microbiology Miscellaneous Phosphates - pharmacology Polysaccharides, Bacterial - administration & dosage Polysaccharides, Bacterial - immunology Rats Rats, Sprague-Dawley Tetanus Tetanus Toxoid - immunology Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Virulence Factors, Bordetella - immunology
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