Relevance of Toll-like receptor-4 polymorphisms in renal transplantation
Relevance of Toll-like receptor-4 polymorphisms in renal transplantation. Polymorphisms in Toll-like receptor-4 (TLR4) have been reported to be associated with a blunted immune response to microbial pathogens, as well as a decreased risk of atherosclerosis in the general population. We assessed the...
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| creator | Ducloux, Didier Deschamps, Marina Yannaraki, Maria Ferrand, Christophe Bamoulid, Jamal Saas, Philippe Kazory, Amir Chalopin, Jean-Marc Tiberghien, Pierre |
| description | Relevance of Toll-like receptor-4 polymorphisms in renal transplantation.
Polymorphisms in Toll-like receptor-4 (TLR4) have been reported to be associated with a blunted immune response to microbial pathogens, as well as a decreased risk of atherosclerosis in the general population. We assessed the impact of the two TLR4 variants on the risk of severe infection, the incidence of acute rejection, and the occurrence of atherosclerotic complications in renal transplant recipients (RTR).
TLR-4 polymorphisms were assessed in a cohort of 238 RTR. Post-transplant atherosclerotic events, acute rejection, severe bacterial infection, cytomegalovirus (CMV) disease, and opportunistic infections were evaluated as outcomes.
The patients were followed for a mean duration of 95 ± 29 months after transplant. TLR4 polymorphism was observed in 27 (11.3%) RTR. Subjects with TLR4 polymorphisms were less likely to experience post-transplant atherosclerotic events (RR 0.44; 95% CI 0.21 to 0.93; P = 0.02) and acute rejection (RR 0.41; 95% CI 0.30 to 0.83; P = 0.01), but presented severe bacterial infections (RR 1.33; 95% CI 1.12 to 1.67; P = 0.01) and opportunistic infections (RR 3.03; 95% CI 1.72 to 8.29; P = 0.008) more frequently. TLR4 polymorphism was marginally associated with CMV disease (RR 1.47; 95% CI 0.95 to 2.64; P = 0.08).
RTR with TLR4 polymorphism present a lower risk of post-transplant atherosclerotic events and acute allograft rejection, but experience severe infectious episodes more frequently. This subset of RTR may benefit from a less potent immunosuppression regimen, along with increased preventive measures against infectious agents. |
| doi_str_mv | 10.1111/j.1523-1755.2005.00354.x |
| format | Article |
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Polymorphisms in Toll-like receptor-4 (TLR4) have been reported to be associated with a blunted immune response to microbial pathogens, as well as a decreased risk of atherosclerosis in the general population. We assessed the impact of the two TLR4 variants on the risk of severe infection, the incidence of acute rejection, and the occurrence of atherosclerotic complications in renal transplant recipients (RTR).
TLR-4 polymorphisms were assessed in a cohort of 238 RTR. Post-transplant atherosclerotic events, acute rejection, severe bacterial infection, cytomegalovirus (CMV) disease, and opportunistic infections were evaluated as outcomes.
The patients were followed for a mean duration of 95 ± 29 months after transplant. TLR4 polymorphism was observed in 27 (11.3%) RTR. Subjects with TLR4 polymorphisms were less likely to experience post-transplant atherosclerotic events (RR 0.44; 95% CI 0.21 to 0.93; P = 0.02) and acute rejection (RR 0.41; 95% CI 0.30 to 0.83; P = 0.01), but presented severe bacterial infections (RR 1.33; 95% CI 1.12 to 1.67; P = 0.01) and opportunistic infections (RR 3.03; 95% CI 1.72 to 8.29; P = 0.008) more frequently. TLR4 polymorphism was marginally associated with CMV disease (RR 1.47; 95% CI 0.95 to 2.64; P = 0.08).
RTR with TLR4 polymorphism present a lower risk of post-transplant atherosclerotic events and acute allograft rejection, but experience severe infectious episodes more frequently. This subset of RTR may benefit from a less potent immunosuppression regimen, along with increased preventive measures against infectious agents.</description><identifier>ISSN: 0085-2538</identifier><identifier>EISSN: 1523-1755</identifier><identifier>DOI: 10.1111/j.1523-1755.2005.00354.x</identifier><identifier>PMID: 15882292</identifier><identifier>CODEN: KDYIA5</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>acute rejection ; Adult ; Aged ; Arteriosclerosis - etiology ; Biological and medical sciences ; cardiovascular disease ; Cytomegalovirus ; Cytomegalovirus Infections - etiology ; Female ; Graft Rejection ; Humans ; infection ; Kidney Transplantation - adverse effects ; Kidney Transplantation - immunology ; Male ; Medical sciences ; Membrane Glycoproteins - genetics ; Membrane Glycoproteins - physiology ; Middle Aged ; Nephrology. Urinary tract diseases ; Opportunistic Infections - etiology ; Polymorphism, Genetic ; Receptors, Cell Surface - genetics ; Receptors, Cell Surface - physiology ; renal transplantation ; TLR4 polymorphism ; Toll-Like Receptor 4 ; Toll-Like Receptors</subject><ispartof>Kidney international, 2005-06, Vol.67 (6), p.2454-2461</ispartof><rights>2005 International Society of Nephrology</rights><rights>2005 INIST-CNRS</rights><rights>Copyright Nature Publishing Group Jun 2005</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c576t-cc089a508ee8308e9de71c216db12a5615218fa7c2b80a8307fb0003c0cf82633</citedby><cites>FETCH-LOGICAL-c576t-cc089a508ee8308e9de71c216db12a5615218fa7c2b80a8307fb0003c0cf82633</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16840488$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15882292$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ducloux, Didier</creatorcontrib><creatorcontrib>Deschamps, Marina</creatorcontrib><creatorcontrib>Yannaraki, Maria</creatorcontrib><creatorcontrib>Ferrand, Christophe</creatorcontrib><creatorcontrib>Bamoulid, Jamal</creatorcontrib><creatorcontrib>Saas, Philippe</creatorcontrib><creatorcontrib>Kazory, Amir</creatorcontrib><creatorcontrib>Chalopin, Jean-Marc</creatorcontrib><creatorcontrib>Tiberghien, Pierre</creatorcontrib><title>Relevance of Toll-like receptor-4 polymorphisms in renal transplantation</title><title>Kidney international</title><addtitle>Kidney Int</addtitle><description>Relevance of Toll-like receptor-4 polymorphisms in renal transplantation.
Polymorphisms in Toll-like receptor-4 (TLR4) have been reported to be associated with a blunted immune response to microbial pathogens, as well as a decreased risk of atherosclerosis in the general population. We assessed the impact of the two TLR4 variants on the risk of severe infection, the incidence of acute rejection, and the occurrence of atherosclerotic complications in renal transplant recipients (RTR).
TLR-4 polymorphisms were assessed in a cohort of 238 RTR. Post-transplant atherosclerotic events, acute rejection, severe bacterial infection, cytomegalovirus (CMV) disease, and opportunistic infections were evaluated as outcomes.
The patients were followed for a mean duration of 95 ± 29 months after transplant. TLR4 polymorphism was observed in 27 (11.3%) RTR. Subjects with TLR4 polymorphisms were less likely to experience post-transplant atherosclerotic events (RR 0.44; 95% CI 0.21 to 0.93; P = 0.02) and acute rejection (RR 0.41; 95% CI 0.30 to 0.83; P = 0.01), but presented severe bacterial infections (RR 1.33; 95% CI 1.12 to 1.67; P = 0.01) and opportunistic infections (RR 3.03; 95% CI 1.72 to 8.29; P = 0.008) more frequently. TLR4 polymorphism was marginally associated with CMV disease (RR 1.47; 95% CI 0.95 to 2.64; P = 0.08).
RTR with TLR4 polymorphism present a lower risk of post-transplant atherosclerotic events and acute allograft rejection, but experience severe infectious episodes more frequently. This subset of RTR may benefit from a less potent immunosuppression regimen, along with increased preventive measures against infectious agents.</description><subject>acute rejection</subject><subject>Adult</subject><subject>Aged</subject><subject>Arteriosclerosis - etiology</subject><subject>Biological and medical sciences</subject><subject>cardiovascular disease</subject><subject>Cytomegalovirus</subject><subject>Cytomegalovirus Infections - etiology</subject><subject>Female</subject><subject>Graft Rejection</subject><subject>Humans</subject><subject>infection</subject><subject>Kidney Transplantation - adverse effects</subject><subject>Kidney Transplantation - immunology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Membrane Glycoproteins - genetics</subject><subject>Membrane Glycoproteins - physiology</subject><subject>Middle Aged</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Opportunistic Infections - etiology</subject><subject>Polymorphism, Genetic</subject><subject>Receptors, Cell Surface - genetics</subject><subject>Receptors, Cell Surface - physiology</subject><subject>renal transplantation</subject><subject>TLR4 polymorphism</subject><subject>Toll-Like Receptor 4</subject><subject>Toll-Like Receptors</subject><issn>0085-2538</issn><issn>1523-1755</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkUFr3DAQhUVoSTZp_kIxgeZmdyRZtnxsQ5oUAoWSnoVWHhNtZcuRvCH5953tLg30Eh0khvlmeHqPsYJDxel83lRcCVnyVqlKAKgKQKq6ej5iq3-Nd2wFoFUplNQn7DTnDVDdSThmJ1xpLUQnVuz2JwZ8spPDIg7FfQyhDP43FgkdzktMZV3MMbyMMc0PPo-58BP1JhuKJdkpz8FOi118nD6w94MNGc8P7xn79e36_uq2vPtx8_3qy13pVNsspXOkwSrQiFrS3fXYcid406-5sKoh-VwPtnVircES0g5r0i0duEGLRsozdrnfO6f4uMW8mNFnh4GEYNxm07QaOtGoN0HetUIo4ARe_Adu4jbRF7MRHLgQEmqC9B5yKeaccDBz8qNNL4aD2WViNmZnvdlZb3aZmL-ZmGca_XjYv12P2L8OHkIg4NMBsNnZMJCxzudXrtE11FoT93XPIfn75DGZ7DxSdL2nuBbTR_-2mj_ujKjn</recordid><startdate>20050601</startdate><enddate>20050601</enddate><creator>Ducloux, Didier</creator><creator>Deschamps, Marina</creator><creator>Yannaraki, Maria</creator><creator>Ferrand, Christophe</creator><creator>Bamoulid, Jamal</creator><creator>Saas, Philippe</creator><creator>Kazory, Amir</creator><creator>Chalopin, Jean-Marc</creator><creator>Tiberghien, Pierre</creator><general>Elsevier Inc</general><general>Nature Publishing</general><general>Elsevier Limited</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7QL</scope><scope>7T5</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20050601</creationdate><title>Relevance of Toll-like receptor-4 polymorphisms in renal transplantation</title><author>Ducloux, Didier ; Deschamps, Marina ; Yannaraki, Maria ; Ferrand, Christophe ; Bamoulid, Jamal ; Saas, Philippe ; Kazory, Amir ; Chalopin, Jean-Marc ; Tiberghien, Pierre</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c576t-cc089a508ee8308e9de71c216db12a5615218fa7c2b80a8307fb0003c0cf82633</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>acute rejection</topic><topic>Adult</topic><topic>Aged</topic><topic>Arteriosclerosis - etiology</topic><topic>Biological and medical sciences</topic><topic>cardiovascular disease</topic><topic>Cytomegalovirus</topic><topic>Cytomegalovirus Infections - etiology</topic><topic>Female</topic><topic>Graft Rejection</topic><topic>Humans</topic><topic>infection</topic><topic>Kidney Transplantation - adverse effects</topic><topic>Kidney Transplantation - immunology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Membrane Glycoproteins - genetics</topic><topic>Membrane Glycoproteins - physiology</topic><topic>Middle Aged</topic><topic>Nephrology. Urinary tract diseases</topic><topic>Opportunistic Infections - etiology</topic><topic>Polymorphism, Genetic</topic><topic>Receptors, Cell Surface - genetics</topic><topic>Receptors, Cell Surface - physiology</topic><topic>renal transplantation</topic><topic>TLR4 polymorphism</topic><topic>Toll-Like Receptor 4</topic><topic>Toll-Like Receptors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ducloux, Didier</creatorcontrib><creatorcontrib>Deschamps, Marina</creatorcontrib><creatorcontrib>Yannaraki, Maria</creatorcontrib><creatorcontrib>Ferrand, Christophe</creatorcontrib><creatorcontrib>Bamoulid, Jamal</creatorcontrib><creatorcontrib>Saas, Philippe</creatorcontrib><creatorcontrib>Kazory, Amir</creatorcontrib><creatorcontrib>Chalopin, Jean-Marc</creatorcontrib><creatorcontrib>Tiberghien, Pierre</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Kidney international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ducloux, Didier</au><au>Deschamps, Marina</au><au>Yannaraki, Maria</au><au>Ferrand, Christophe</au><au>Bamoulid, Jamal</au><au>Saas, Philippe</au><au>Kazory, Amir</au><au>Chalopin, Jean-Marc</au><au>Tiberghien, Pierre</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relevance of Toll-like receptor-4 polymorphisms in renal transplantation</atitle><jtitle>Kidney international</jtitle><addtitle>Kidney Int</addtitle><date>2005-06-01</date><risdate>2005</risdate><volume>67</volume><issue>6</issue><spage>2454</spage><epage>2461</epage><pages>2454-2461</pages><issn>0085-2538</issn><eissn>1523-1755</eissn><coden>KDYIA5</coden><abstract>Relevance of Toll-like receptor-4 polymorphisms in renal transplantation.
Polymorphisms in Toll-like receptor-4 (TLR4) have been reported to be associated with a blunted immune response to microbial pathogens, as well as a decreased risk of atherosclerosis in the general population. We assessed the impact of the two TLR4 variants on the risk of severe infection, the incidence of acute rejection, and the occurrence of atherosclerotic complications in renal transplant recipients (RTR).
TLR-4 polymorphisms were assessed in a cohort of 238 RTR. Post-transplant atherosclerotic events, acute rejection, severe bacterial infection, cytomegalovirus (CMV) disease, and opportunistic infections were evaluated as outcomes.
The patients were followed for a mean duration of 95 ± 29 months after transplant. TLR4 polymorphism was observed in 27 (11.3%) RTR. Subjects with TLR4 polymorphisms were less likely to experience post-transplant atherosclerotic events (RR 0.44; 95% CI 0.21 to 0.93; P = 0.02) and acute rejection (RR 0.41; 95% CI 0.30 to 0.83; P = 0.01), but presented severe bacterial infections (RR 1.33; 95% CI 1.12 to 1.67; P = 0.01) and opportunistic infections (RR 3.03; 95% CI 1.72 to 8.29; P = 0.008) more frequently. TLR4 polymorphism was marginally associated with CMV disease (RR 1.47; 95% CI 0.95 to 2.64; P = 0.08).
RTR with TLR4 polymorphism present a lower risk of post-transplant atherosclerotic events and acute allograft rejection, but experience severe infectious episodes more frequently. This subset of RTR may benefit from a less potent immunosuppression regimen, along with increased preventive measures against infectious agents.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>15882292</pmid><doi>10.1111/j.1523-1755.2005.00354.x</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | acute rejection Adult Aged Arteriosclerosis - etiology Biological and medical sciences cardiovascular disease Cytomegalovirus Cytomegalovirus Infections - etiology Female Graft Rejection Humans infection Kidney Transplantation - adverse effects Kidney Transplantation - immunology Male Medical sciences Membrane Glycoproteins - genetics Membrane Glycoproteins - physiology Middle Aged Nephrology. Urinary tract diseases Opportunistic Infections - etiology Polymorphism, Genetic Receptors, Cell Surface - genetics Receptors, Cell Surface - physiology renal transplantation TLR4 polymorphism Toll-Like Receptor 4 Toll-Like Receptors |
| title | Relevance of Toll-like receptor-4 polymorphisms in renal transplantation |
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