Prodrug of proline analogue reduces hypoxic pulmonary hypertension in rats

A polymeric prodrug of the proline analogue cis-4-hydroxy- l-proline (CHOP), poly(ethylene glycol)-lysine-CHOP or CHOP-PEG, prevents hypoxic pulmonary hypertension in rats by inhibiting collagen accumulation. A more potent prodrug was synthesized by increasing the loading of CHOP on the carrier from...

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Veröffentlicht in:	Pulmonary pharmacology & therapeutics 2006-01, Vol.19 (4), p.242-250
Hauptverfasser:	Simon, Paul M., Pachence, James, Belinka, Benjamin, Poiani, George J., Lu, Shou-En, Tozzi, Carol A., Riley, David J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antihypertensive agents Blood Pressure - drug effects Collagen Dose-Response Relationship, Drug Drug delivery systems Fibrosis Hydroxyproline - administration & dosage Hydroxyproline - chemistry Hydroxyproline - therapeutic use Hypertension Hypertension, Pulmonary - drug therapy Hypertension, Pulmonary - etiology Hypoxia - complications Infusion Pumps Injections, Intravenous Injections, Spinal Injections, Subcutaneous Lysine - analogs & derivatives Lysine - chemistry Male Polyethylene Glycols - chemistry Prodrugs - pharmacokinetics Prodrugs - pharmacology Prodrugs - therapeutic use Proline - analogs & derivatives Proline - therapeutic use Pulmonary Pulmonary Artery - physiology Rats Rats, Sprague-Dawley Time Factors Treatment Outcome
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