Microglia potentiate damage to blood-brain barrier constituents : Improvement by minocycline in vivo and in vitro

Blood-brain barrier (BBB) disruption after stroke can worsen ischemic injury by increasing edema and causing hemorrhage. We determined the effect of microglia on the BBB and its primary constituents, endothelial cells (ECs) and astrocytes, after ischemia using in vivo and in vitro models. Primary as...

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Veröffentlicht in:	Stroke (1970) 2006-04, Vol.37 (4), p.1087-1093
Hauptverfasser:	YENARI, Midori A, LIJUN XU, XIAN NAN TANG, YANLI QIAO, GIFFARD, Rona G
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetophenones - pharmacology Animals Antioxidants - pharmacology Astrocytes - pathology Biological and medical sciences Blood-Brain Barrier - drug effects Brain - pathology Brain Ischemia - complications Brain Ischemia - metabolism Brain Ischemia - pathology Brain Ischemia - physiopathology Cell Death - drug effects Cells, Cultured Cerebral Hemorrhage - etiology Cerebral Hemorrhage - physiopathology Cerebral Infarction - pathology Coculture Techniques Diseases of the nervous system Endothelial Cells - pathology Glucose - deficiency Hydrogen Peroxide - metabolism Hypoxia - metabolism Investigative techniques, diagnostic techniques (general aspects) Male Medical sciences Mice Mice, Inbred C57BL Microglia - drug effects Microglia - metabolism Microglia - pathology Minocycline - pharmacology Nervous system Nervous System Diseases - etiology Nervous System Diseases - physiopathology Neurology Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) Superoxides - metabolism Tumor Necrosis Factor-alpha - metabolism Ultrasonic investigative techniques Vascular diseases and vascular malformations of the nervous system
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