Identification of degradation products from aqueous carboplatin injection samples by electrospray mass spectrometry

Four different carboplatin injection samples in water (∼10 mg/ml) stored at room temperature were investigated for degradation products by electrospray liquid chromatography-mass spectrometry (ESI/LC–MS). A mass spectrometer compatible mobile phase system with 0.02% formic acid and methanol was used...

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Veröffentlicht in:	International journal of pharmaceutics 2006-04, Vol.313 (1), p.214-221
Hauptverfasser:	Vivekanandan, Kannan, Swamy, Madugundu Guru, Prasad, Sudhanand, Maikap, Golak Chandra, Mukherjee, Rama, Burman, Anand C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - chemistry Biological and medical sciences Carboplatin Carboplatin - chemistry Drug Stability Electrospray General pharmacology LC–MS Medical sciences Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Solutions Spectrometry, Mass, Electrospray Ionization
Online-Zugang:	Volltext
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