The nonviral episomal replicating vector pEPI-1 allows long-term inhibition of bcr-abl expression by shRNA

The inhibition of gene expression by RNA interference harbors a high potential for application in the therapy of human diseases. However, while exogenous application of siRNAs efficiently inhibits gene expression, these effects are only transient in mammalian cells. We designed a short hairpin RNA-e...

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Veröffentlicht in:	Human gene therapy 2005-04, Vol.16 (4), p.533-539
Hauptverfasser:	JENKE, Andreas C. W, EISENBERGER, Tobias, BAIKER, Armin, STEHLE, Isa M, WIRTH, Stefan, LIPPS, Hans Joachim
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Applied cell therapy and gene therapy Base Sequence Biological and medical sciences Biotechnology Blotting, Northern Blotting, Western Cell Proliferation Cytokines - metabolism DNA Polymerase III - genetics Fundamental and applied biological sciences. Psychology Fusion Proteins, bcr-abl - drug effects Fusion Proteins, bcr-abl - genetics Gene Expression Regulation - drug effects Gene therapy Genetic Vectors - genetics Genetic Vectors - pharmacology Health. Pharmaceutical industry Humans Industrial applications and implications. Economical aspects K562 Cells Medical sciences Molecular Sequence Data Plasmids - genetics Promoter Regions, Genetic RNA - chemistry RNA - genetics RNA - pharmacology RNA, Catalytic - chemistry Transfusions. Complications. Transfusion reactions. Cell and gene therapy Virus Replication - genetics
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